relation: https://eprints.gla.ac.uk/151758/
title: The utility of anti-Müllerian hormone in women with chronic kidney disease, on haemodialysis and after kidney transplantation
creator: Stoumpos, Sokratis
creator: Lees, Jennifer
creator: Welsh, Paul
creator: Hund, Martin
creator: Geddes, Colin C.
creator: Nelson, Scott M.
creator: Mark, Patrick B.
description: Women with renal disease have menstrual and gonadal dysfunction manifesting as hormonal imbalance. Anti-Müllerian hormone (AMH) is a potential measure of ovarian reserve. We examined circulating AMH concentrations in young women with renal failure, determined associations with clinical characteristics, and compared AMH with age-matched healthy individuals. AMH was measured in 77 women: 26 had chronic kidney disease (CKD), 26 were on haemodialysis (HD), and 25 had a kidney transplant. Random AMH levels were highest in women on HD [HD 2.9 (1.1–5.2), CKD 1.6 (0.7–2.2), transplant 1.5 (1.0–4.2) ng/ml]. On multiple linear regression, AMH was 53% higher [95% CI 0.20–0.98, P = 0.002] in women on HD and decreased by 20% per 5-year increase in age (P < 0.001). AMH was 43% lower in women with renal failure compared with 600 age-matched controls [1.7 (0.9–3.8) versus 3.0 (1.9–5.0) ng/ml, P < 0.001]; however, we found no difference in AMH between those on HD and healthy individuals [2.9 (1.1–5.2) versus 3.0 (1.9–5.0) ng/ml]. AMH may be a useful biomarker in female renal patients with non-dialysis dependent renal disease pursuing pregnancy. In contrast, AMH levels are higher in HD but unlikely to reflect ovarian reserve.
publisher: Elsevier
date: 2018-02
type: Articles
type: PeerReviewed
format: text
language: en
rights: cc_by_nc_nd_4
identifier: https://eprints.gla.ac.uk/151758/13/151758.pdf
identifier:    Stoumpos, S. <http://eprints.gla.ac.uk/view/author/36389.html>, Lees, J. <http://eprints.gla.ac.uk/view/author/37396.html>  <http://orcid.org/0000-0001-6331-0178>, Welsh, P. <http://eprints.gla.ac.uk/view/author/10502.html>  <http://orcid.org/0000-0002-7970-3643>, Hund, M., Geddes, C. C. <http://eprints.gla.ac.uk/view/author/3190.html>, Nelson, S. M. <http://eprints.gla.ac.uk/view/author/12999.html>  <http://orcid.org/0000-0002-9099-3047> and Mark, P. B. <http://eprints.gla.ac.uk/view/author/10280.html>  <http://orcid.org/0000-0003-3387-2123>  (2018)  The utility of anti-Müllerian hormone in women with chronic kidney disease, on haemodialysis and after kidney transplantation.   Reproductive BioMedicine Online <https://eprints.gla.ac.uk/view/journal_volume/Reproductive_BioMedicine_Online.html>, 36(2),  pp. 219-226.   (doi: 10.1016/j.rbmo.2017.11.003 <https://doi.org/10.1016/j.rbmo.2017.11.003>) (PMID:29233504)        
relation: 10.1016/j.rbmo.2017.11.003