eprintid: 149490 rev_number: 6 eprint_status: archive userid: 15745 dir: disk0/00/14/94/90 datestamp: 2017-10-11 08:48:20 lastmod: 2022-09-14 10:10:45 status_changed: 2017-10-11 08:48:20 type: article metadata_visibility: show creators_name: Baumert, Mathias creators_name: Porta, Alberto creators_name: Vos, Marc A. creators_name: Malik, Marek creators_name: Couderc, Jean-Philippe creators_name: Laguna, Pablo creators_name: Piccirillo, Gianfranco creators_name: Smith, Godfrey L. creators_name: Tereshchenko, Larisa G. creators_name: Volders, Paul G.A. creators_orcid: 0000-0003-4821-9741 title: QT interval variability in body surface ECG: measurement, physiological basis, and clinical value: position statement and consensus guidance endorsed by the European Heart Rhythm Association jointly with the ESC Working Group on Cardiac Cellular Electrophysiology ispublished: pub divisions: 25200000 full_text_status: none abstract: This consensus guideline discusses the electrocardiographic phenomenon of beat-to-beat QT interval variability (QTV) on surface electrocardiograms. The text covers measurement principles, physiological basis, and clinical value of QTV. Technical considerations include QT interval measurement and the relation between QTV and heart rate variability. Research frontiers of QTV include understanding of QTV physiology, systematic evaluation of the link between QTV and direct measures of neural activity, modelling of the QTV dependence on the variability of other physiological variables, distinction between QTV and general T wave shape variability, and assessing of the QTV utility for guiding therapy. Increased QTV appears to be a risk marker of arrhythmic and cardiovascular death. It remains to be established whether it can guide therapy alone or in combination with other risk factors. QT interval variability has a possible role in non-invasive assessment of tonic sympathetic activity. date: 2016-06 date_type: published publication: Europace volume: 18 number: 6 publisher: Oxford University Press pagerange: 925-944 id_number: 10.1093/europace/euv405 refereed: TRUE issn: 1099-5129 uniqueid: glaseprints:2016-149490 issn_online: 1532-2092 pubmed_id: 26823389 euro_pubmed_id: 26823389 pmcid: PMC4905605 hoa_compliant: 305 hoa_date_acc: 2015-11-05 hoa_date_pub: 2016-01-27 hoa_exclude: FALSE hoa_gold: FALSE citation: Baumert, M., Porta, A., Vos, M. A., Malik, M., Couderc, J.-P., Laguna, P., Piccirillo, G., Smith, G. L. , Tereshchenko, L. G. and Volders, P. G.A. (2016) QT interval variability in body surface ECG: measurement, physiological basis, and clinical value: position statement and consensus guidance endorsed by the European Heart Rhythm Association jointly with the ESC Working Group on Cardiac Cellular Electrophysiology. Europace , 18(6), pp. 925-944. (doi: 10.1093/europace/euv405 ) (PMID:26823389) (PMCID:PMC4905605)