TY  - JOUR
ID  - enlighten144195
UR  - https://eprints.gla.ac.uk/144195/
IS  - 3
A1  - Damy, Thibaud
A1  - Kallvikbacka-Bennett, Anna
A1  - Goode, Kevin
A1  - Khaleva, Olga
A1  - Lewinter, Christian
A1  - Hobkirk, James
A1  - Nikitin, Nikolay P.
A1  - Dubois-Randé, Jean-Luc
A1  - Hittinger, Luc
A1  - Clark, Andrew L.
A1  - Cleland, John G.F.
Y1  - 2012/03//
N2  - Background:

Prevalence, predictors, and prognostic value of right ventricular (RV) function measured by the tricuspid annular plane systolic excursion (TAPSE) in patients with chronic heart failure (CHF) symptoms with a broad range of left ventricular ejection fraction (LVEF) are unknown.

Methods and Results:

Of 1,547 patients, mean (±SD) age was 71 ± 11 years, 48% were women, median (interquartile range [IQR]) TAPSE was 18.5 (14.0?22.7) mm, mean LVEF was 47 ± 16%, 47% had LVEF ?45% and 67% were diagnosed with CHF, defined as systolic (S-HF) if LVEF was ?45% and as heart failure with preserved ejection fraction (HFPEF) if LVEF was >45% and treated with a loop diuretic. During a median (IQR) follow-up of 63 (41?75) months, mortality was 34%. In multivariable analysis, increasing age, N-terminal pro?B-type natriuretic peptide (NT-proBNP), New York Heart Association functional class, right atrial volume index, and transtricuspid pressure gradient; lower TAPSE, diastolic blood pressure, and hemoglobin; and atrial fibrillation (AF) or COPD were associated with an adverse prognosis. Receiver operating characteristic curve analysis identified a TAPSE of 15.9 mm as the best prognostic threshold (P = .0001); 47% of S-HF and 20% of HFPEF had a TAPSE of <15.9 mm. The main associations with a TAPSE <15.9 mm were higher NT-proBNP, presence of atrial fibrillation and presence of LV systolic dysfunction.
Conclusions:

In patients with CHF, low values for TAPSE are common, especially in those with reduced LVEF. TAPSE, unlike LVEF, was an independent predictor of outcome.
PB  - Elsevier
JF  - Journal of Cardiac Failure
VL  - 18
SN  - 1071-9164
TI  - Prevalence of, associations with, and prognostic value of Tricuspid Annular Plane Systolic Excursion (TAPSE) among out-patients referred for the evaluation of heart failure
SP  - 216
AV  - none
EP  - 225
ER  -