TY  - JOUR
ID  - enlighten137915
UR  - https://eprints.gla.ac.uk/137915/
IS  - 8
A1  - Linde, Cecilia
A1  - Abraham, William T.
A1  - Gold, Michael R.
A1  - Daubert, Claude
A1  - Tang, Anthony S.L.
A1  - Young, James B.
A1  - Sherfesee, Lou
A1  - Hudnall, Harrison
A1  - Fagan, Dedra H.
A1  - Cleland, John G.
Y1  - 2017/08//
N2  - Aims: 

Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in patients with symptomatic heart failure and QRS prolongation but there is uncertainty about which patient characteristics predict short-term clinical response.
Methods and results: 

In an individual patient meta-analysis of three double-blind, randomized trials, clinical composite score (CCS) at 6 months was compared in patients assigned to CRT programmed on or off. Treatment?covariate interactions were assessed to measure likelihood of improved CCS at 6 months. MIRACLE, MIRACLE ICD, and REVERSE trials contributed data for this analysis (n = 1591). Multivariable modelling identified QRS duration and left ventricular ejection fraction (LVEF) as predictors of CRT clinical response (P < 0.05). The odds ratio for a better CCS at 6 months increased by 3.7% for every 1% decrease in LVEF for patients assigned to CRT-on compared to CRT-off, and was greatest when QRS duration was between 160 and 180?ms.
Conclusions: 

In symptomatic chronic heart failure patients (NYHA class II?IV), longer QRS duration and lower LVEF independently predict early clinical response to CRT.
PB  - Wiley
JF  - European Journal of Heart Failure
VL  - 19
SN  - 1388-9842
TI  - Predictors of short-term clinical response to cardiac resynchronization therapy
SP  - 1056
AV  - public
EP  - 1063
ER  -