eprintid: 136166
rev_number: 33
eprint_status: archive
userid: 9223
dir: disk0/00/13/61/66
datestamp: 2017-02-28 14:32:19
lastmod: 2022-08-01 09:29:09
status_changed: 2017-02-28 14:32:19
type: article
metadata_visibility: show
creators_name: Farkašová, Helena
creators_name: Hron, Tomáš
creators_name: Pačes, Jan
creators_name: Hulva, Pavel
creators_name: Benda, Petr
creators_name: Gifford, Robert James
creators_name: Elleder, Daniel
creators_orcid: 0000-0003-4028-9884
title: Discovery of an endogenous Deltaretrovirus in the genome of long-fingered bats (Chiroptera: Miniopteridae)
ispublished: pub
divisions: 25300000
divisions: 25303100
abstract: Retroviruses can create endogenous forms on infiltration into the germline cells of their hosts. These forms are then vertically transmitted and can be considered as genetic fossils of ancient viruses. All retrovirus genera, with the exception of deltaretroviruses, have had their representation identified in the host genome as a virus fossil record. Here we describe an endogenous Deltaretrovirus, identified in the germline of long-fingered bats (Miniopteridae). A single, heavily deleted copy of this retrovirus has been found in the genome of miniopterid species, but not in the genomes of the phylogenetically closest bat families, Vespertilionidae and Cistugonidae. Therefore, the endogenization occurred in a time interval between 20 and 45 million years ago. This discovery closes the last major gap in the retroviral fossil record and provides important insights into the history of deltaretroviruses in mammals.
date: 2017-03-21
date_type: published
publisher: National Academy of Sciences
id_number: 10.1073/pnas.1621224114
uniqueid: glaseprints:2017-136166
issn_online: 1091-6490
pubmed_id: 28280099
euro_pubmed_id: 28280099
pmcid: PMC5373376
full_text_status: none
publication: Proceedings of the National Academy of Sciences of the United States of America
volume: 114
number: 12
pagerange: 3145-3150
refereed: TRUE
issn: 0027-8424
oa_research_materials_ack: No
hoa_compliant: 304
hoa_emb_len: 0
hoa_ref_pan: AB
hoa_date_acc: 2017-02-01
hoa_date_pub: 2017-03-09
hoa_exclude: FALSE
hoa_gold: FALSE
rioxx2_apc_input: not required
citation:    Farkašová, Helena, Hron, Tomáš, Pačes, Jan, Hulva, Pavel, Benda, Petr, Gifford, Robert James <https://eprints.gla.ac.uk/view/author/31340.html> and Elleder, Daniel  (2017)  Discovery of an endogenous Deltaretrovirus in the genome of long-fingered bats (Chiroptera: Miniopteridae).   Proceedings of the National Academy of Sciences of the United States of America <https://eprints.gla.ac.uk/view/journal_volume/Proceedings_of_the_National_Academy_of_Sciences_of_the_United_States_of_America.html>, 114(12),  pp. 3145-3150.   (doi: 10.1073/pnas.1621224114 <https://doi.org/10.1073/pnas.1621224114>) (PMID:28280099)  (PMCID:PMC5373376)