RT Journal Article
SR 00
ID 10.1073/pnas.1621224114
A1 Farkašová, Helena
A1 Hron, Tomáš
A1 Pačes, Jan
A1 Hulva, Pavel
A1 Benda, Petr
A1 Gifford, Robert James
A1 Elleder, Daniel
T1 Discovery of an endogenous Deltaretrovirus in the genome of long-fingered bats (Chiroptera: Miniopteridae)
JF Proceedings of the National Academy of Sciences of the United States of America
YR 2017
FD 2017-03-21
VO 114
IS 12
SP 3145
OP 3150
AB Retroviruses can create endogenous forms on infiltration into the germline cells of their hosts. These forms are then vertically transmitted and can be considered as genetic fossils of ancient viruses. All retrovirus genera, with the exception of deltaretroviruses, have had their representation identified in the host genome as a virus fossil record. Here we describe an endogenous Deltaretrovirus, identified in the germline of long-fingered bats (Miniopteridae). A single, heavily deleted copy of this retrovirus has been found in the genome of miniopterid species, but not in the genomes of the phylogenetically closest bat families, Vespertilionidae and Cistugonidae. Therefore, the endogenization occurred in a time interval between 20 and 45 million years ago. This discovery closes the last major gap in the retroviral fossil record and provides important insights into the history of deltaretroviruses in mammals.
PB National Academy of Sciences
SN 0027-8424
LK https://eprints.gla.ac.uk/136166/