%A Kenneth Mangion
%A Hao Gao
%A Christie Mccomb
%A David Carrick
%A Guillaume Clerfond
%A Xiadong Zhong
%A Xiaoyu Luo
%A Caroline Haig
%A Colin Berry
%J Scientific Reports
%T A novel method for estimating myocardial strain: assessment of deformation tracking against reference magnetic resonance methods in healthy volunteers
%X We developed a novel method for tracking myocardial deformation using cardiac magnetic resonance (CMR) cine imaging. We hypothesised that circumferential strain using deformation-tracking has comparable diagnostic performance to a validated method (Displacement Encoding with Stimulated Echoes- DENSE) and potentially diagnostically superior to an established cine-strain method (feature-tracking). 
81 healthy adults (44.6 ? 17.7 years old, 47% male), without any history of cardiovascular disease, underwent CMR at 1.5T including cine, DENSE, and late gadolinium enhancement in subjects >45 years. Acquisitions were divided into 6 segments, and global and segmental peak circumferential strain were derived and analysed by age and sex. 
Peak circumferential strain differed between the 3 groups (DENSE: -19.4 ? 4.8 %; deformation-tracking: -16.8 ? 2.4 %; feature-tracking: -28.7 ? 4.8%) (ANOVA with Tukey post-hoc, F-value 279.93, p<0.01). DENSE and deformation-tracking had better reproducibility than feature-tracking. Intra-class correlation co-efficient was >0.90. Larger magnitudes of strain were detected in women using deformation-tracking and DENSE, but not feature-tracking. 
Compared with a reference method (DENSE), deformation-tracking using cine imaging has similar diagnostic performance for circumferential strain assessment in healthy individuals. Deformation-tracking could potentially obviate the need for bespoke strain sequences, reducing scanning time and is more reproducible than feature-tracking.
%V 6
%D 2016
%R 10.1038/srep38774
%I Nature Research
%L enlighten131264