RT Journal Article
SR 00
ID 10.1016/j.kint.2016.06.014
A1 Rutherford, Elaine
A1 Talle, Mohammed A.
A1 Mangion, Kenneth
A1 Bell, Elizabeth
A1 Rauhalammi, Samuli M.
A1 Roditi, Giles
A1 McComb, Christie
A1 Radjenovic, Aleksandra
A1 Welsh, Paul
A1 Woodward, Rosemary
A1 Struthers, Allan D.
A1 Jardine, Alan G.
A1 Patel, Rajan K.
A1 Berry, Colin
A1 Mark, Patrick B.
T1 Definition of myocardial tissue abnormalities in end stage renal failure with cardiac magnetic resonance imaging using T1 mapping
JF Kidney International
YR 2016
FD 2016-10
VO 90
IS 4
SP 845
OP 852
AB Noninvasive quantification of myocardial fibrosis in end-stage renal disease is challenging. Gadolinium contrast agents previously used for cardiac magnetic resonance imaging (MRI) are contraindicated because of an association with nephrogenic systemic fibrosis. In other populations, increased myocardial native T1 times on cardiac MRI have been shown to be a surrogate marker of myocardial fibrosis. We applied this method to 33 incident hemodialysis patients and 28 age- and sex-matched healthy volunteers who underwent MRI at 3.0T. Native T1 relaxation times and feature tracking–derived global longitudinal strain as potential markers of fibrosis were compared and associated with cardiac biomarkers. Left ventricular mass indices were higher in the hemodialysis than the control group. Global, Septal and midseptal T1 times were all significantly higher in the hemodialysis group (global T1 hemodialysis 1171 ± 27 ms vs. 1154 ± 32 ms; septal T1 hemodialysis 1184 ± 29 ms vs. 1163 ± 30 ms; and midseptal T1 hemodialysis 1184 ± 34 ms vs. 1161 ± 29 ms). In the hemodialysis group, T1 times correlated with left ventricular mass indices. Septal T1 times correlated with troponin and electrocardiogram-corrected QT interval. The peak global longitudinal strain was significantly reduced in the hemodialysis group (hemodialysis -17.7±5.3% vs. -21.8±6.2%). For hemodialysis patients, the peak global longitudinal strain significantly correlated with left ventricular mass indices (R = 0.426), and a trend was seen for correlation with galectin-3, a biomarker of cardiac fibrosis. Thus, cardiac tissue properties of hemodialysis patients consistent with myocardial fibrosis can be determined noninvasively and associated with multiple structural and functional abnormalities.
NO We acknowledged British Heart Foundation (FS/15/5431639) training fellowship to Dr Kenneth Mangion (co author) and grant Kidney Research UK (IN02/2013).
PB Elsevier
SN 0085-2538
LK https://eprints.gla.ac.uk/119837/