Abstract
The primary cilium is a sensory organelle that is vital in regulating several signalling pathways. Unlike most organelles cilia are open to the rest of the cell, not enclosed by membranes. The distinct protein composition is crucial to the function of cilia and many signalling proteins and receptors are specifically concentrated within distinct compartments. To maintain this composition, a mechanism is required to deliver proteins to the cilium whilst another must counter the entropic tendency of proteins to distribute throughout the cell. The combination of the two mechanisms should result in the concentration of ciliary proteins to the cilium. In this review we will look at different cellular mechanisms that play a role in maintaining the distinct composition of cilia, including regulation of ciliary access and trafficking of ciliary proteins to, from and within the cilium.
Funding: CRUK (Grant/Award Number: A19257).
References
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Articles in the same Issue
- Frontmatter
- Reviews
- Maintaining protein composition in cilia
- Eremophilane-type sesquiterpenes from fungi and their medicinal potential
- How to get rid of mitochondria: crosstalk and regulation of multiple mitophagy pathways
- Minireviews
- Targeted degradomics in protein terminomics and protease substrate discovery
- Brain plasticity, cognitive functions and neural stem cells: a pivotal role for the brain-specific neural master gene |-SRGAP2–FAM72-|
- Research Articles/Short Communications
- Protein Structure and Function
- Domain topology of human Rasal
- The consequences of deglycosylation of recombinant intra-melanosomal domain of human tyrosinase
- Cell Biology and Signaling
- Locally produced xenin and the neurotensinergic system in pancreatic islet function and β-cell survival
- The long non-coding RNA CRNDE promotes cervical cancer cell growth and metastasis
Articles in the same Issue
- Frontmatter
- Reviews
- Maintaining protein composition in cilia
- Eremophilane-type sesquiterpenes from fungi and their medicinal potential
- How to get rid of mitochondria: crosstalk and regulation of multiple mitophagy pathways
- Minireviews
- Targeted degradomics in protein terminomics and protease substrate discovery
- Brain plasticity, cognitive functions and neural stem cells: a pivotal role for the brain-specific neural master gene |-SRGAP2–FAM72-|
- Research Articles/Short Communications
- Protein Structure and Function
- Domain topology of human Rasal
- The consequences of deglycosylation of recombinant intra-melanosomal domain of human tyrosinase
- Cell Biology and Signaling
- Locally produced xenin and the neurotensinergic system in pancreatic islet function and β-cell survival
- The long non-coding RNA CRNDE promotes cervical cancer cell growth and metastasis