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Licensed Unlicensed Requires Authentication Published by De Gruyter September 26, 2022

Can acute high-altitude sickness be predicted in advance?

  • Yan Guo , Xiao Liu EMAIL logo , Qiang Zhang EMAIL logo , Zhongshan Shi EMAIL logo , Menglan Zhang and Jie Chen

Abstract

In high-altitude environments, the oxygen and air density are decreased, and the temperature and humidity are low. When individuals enter high-altitude areas, they are prone to suffering from acute mountain sickness (AMS) because they cannot tolerate hypoxia. Headache, fatigue, dizziness, and gastrointestinal reactions are the main symptoms of AMS. When these symptoms cannot be effectively alleviated, they can progress to life-threatening high-altitude pulmonary edema or high-altitude cerebral edema. If the risk of AMS can be effectively assessed before people enter high-altitude areas, then the high-risk population can be promptly discouraged from entering the area, or drug intervention can be established in advance to prevent AMS occurrence and avoid serious outcomes. This article reviews recent studies related to the early-warning biological indicators of AMS to provide a new perspective on the prevention of AMS.


Corresponding authors: Xiao Liu, Department of Basic Medical Sciences, The 960th Hospital of PLA, Jinan, Shandong Province, 250031, China, E-mail: ; Qiang Zhang, Department of Neurosurgery, Qinghai Provincial People’s Hospital, Xining, Qinghai Province, 810007, China, E-mail: ; and Zhongshan Shi, Department of Intensive Care Medicine, Ge er mu People’s Hospital, Ge er mu, Qinghai Province, 816099, China, E-mail:

Funding source: The Applied basic research project of Qinghai basic research plan

Award Identifier / Grant number: 2022-zj-765

Funding source: The Guiding scientific research project of health in Qinghai Province

Award Identifier / Grant number: 2021-wjzsx

Acknowledgments

Thank Professor Yuan Cao of the Basic Medical Laboratory of the PLA 960th hospital, for his suggestions on the revision of this article.

  1. Research funding: This work was supported by the Applied basic research project of Qinghai basic research plan, No. 2022-zj-765, and the Guiding scientific research project of health in Qinghai Province, No. 2021-wjzsx.

  2. Author contributions: All authors contributed to the study conception and design. The literature search was completed by Zhongshan Shi, Menglan Zhang and Jie Chen. The first draft of the manuscript was written by Yan Guo and Xiao Liu. Qiang Zhang revised the manuscript. All authors commented on previous versions of the manuscript, and approved the final manuscript.

  3. Competing interests: The authors have no relevant financial or non-financial interests to disclose.

  4. Informed consent: This manuscript is a review and does not require informed consent.

  5. Ethical approval: The local Institutional Review Board deemed the study exempt from review.

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Received: 2022-07-15
Accepted: 2022-09-02
Published Online: 2022-09-26
Published in Print: 2024-03-25

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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