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Preconceptual Zika virus asymptomatic infection protects against secondary prenatal infection

Fig 2

Primary ZIKV asymptomatic infection primes expanded accumulation of IgG antibodies.

(A) IgG, IgA and IgM antibody titers (A₄₅₀) with ZIKV ENV specificity in the serum of mice day 21 after asymptomatic primary infection compared with naive control mice. (B) IgG1, IgG2a, IgG2b, and IgG3 antibody titers (A₄₅₀) with ZIKV ENV specificity in the serum of mice described in panel A. (C) IgG1, IgG2a, IgG2b, and IgG3 antibody titers (A₄₅₀) with ZIKV NS1 specificity in the serum of mice described in panel A. These data are representative of at least three independent experiments each with similar results. Bar, mean ± one standard error.

doi: https://doi.org/10.1371/journal.ppat.1006684.g002