Analysis of the T Cell Response to Zika Virus and Identification of a Novel CD8+ T Cell Epitope in Immunocompetent Mice

doi:10.1371/journal.ppat.1006184

Analysis of the T Cell Response to Zika Virus and Identification of a Novel CD8⁺ T Cell Epitope in Immunocompetent Mice

Fig 4

ZIKV induces CD4⁺ and CD8⁺ T cell activation at the peak of the T cell response.

Representative plots of CD11a⁺CD49d⁺ antigen-experienced CD4⁺ T cells from spleens of mock- (A), UV-inactivated ZIKV- (B) and ZIKV-infected (C) mice 7 dpi. Percentage (D) and number (E) of CD11a⁺CD49d⁺ antigen-experienced CD4⁺ T cells from spleens of mock-, UV-inactivated ZIKV- and ZIKV-infected mice 7 dpi. Representative plots of CD8α^loCD11a^hi antigen-experienced CD8⁺ T cells from the spleens of mock- (F), UV-inactivated ZIKV- (G) and ZIKV-infected (H) mice 7 dpi. Percentage (I) and number (J) of CD8α^loCD11a^hi antigen-experienced CD8⁺ T cells from the spleens of mock-, UV-inactivated ZIKV- and ZIKV-infected mice 7 dpi. Error bars represent mean ± SEM. Data are pooled from two independent experiments, n = 3 mice per group per experiment. Data in (D, E, I and J) were analyzed by one-way ANOVA with Tukey’s post-test of multiple comparisons. ****p<0.0001.

doi: https://doi.org/10.1371/journal.ppat.1006184.g004