Listeria monocytogenes Cytoplasmic Entry Induces Fetal Wastage by Disrupting Maternal Foxp3+ Regulatory T Cell-Sustained Fetal Tolerance

doi:10.1371/journal.ppat.1002873

Listeria monocytogenes Cytoplasmic Entry Induces Fetal Wastage by Disrupting Maternal Foxp3⁺ Regulatory T Cell-Sustained Fetal Tolerance

Figure 5

Cytoplasmic entry is essential for Listeria monocytogenes-induced fetal wastage.

(A) Number of live pups born with LmΔactA (10⁷ CFUs) or LmΔLLOΔPLC (10⁸ CFUs) infection at midgestation (E10.5) in C57Bl/6 females mated with Balb/c males. (B) Percent viable and resorbed fetuses five days after LmΔactA (10⁷ CFUs) or LmΔLLOΔPLC (10⁸ CFUs) infection at midgestation. Each data point represents results from an individual mouse combined from three independent experiments each with similar results.

doi: https://doi.org/10.1371/journal.ppat.1002873.g005