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Effects of the TLR2 Agonists MALP-2 and Pam₃Cys in Isolated Mouse Lungs

Figure 4

Expression of genes in cluster 1.

After 60 min of perfusion under baseline conditions, isolated mouse lungs were perfused for another 180 min with Pam₃Cys (160 ng/mL, n = 5), MALP-2 (25 ng/mL, n = 5), LPS (1 µg/mL, n = 3) or under control conditions (n = 4). Genes: amphiregulin (Areg), angiopoietin-like 2 (Angptl2), heparin-binding epithelial growth fator (HBegf), poly(ADP-ribose)glycohydrolase (Parg), TNF receptor-associated factor 1 (Traf1), and secretory leukocyte peptidase inhibitor (Slpi). Data were normalized to the experimental control and are shown as mean ± SEM. *, p<0.05 vs control; **, p<0.01 vs control; ***, p<0.001 vs control.

doi: https://doi.org/10.1371/journal.pone.0013889.g004