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Characterization of Lethal Zika Virus Infection in AG129 Mice

Fig 1

ZIKV causes mortality and morbidity in AG129 mice.

Kaplan-Meier curves illustrate the susceptibility of AG129 mice to ZIKV. Young mice were inoculated f.p. with several doses (n = 3 for doses 10⁵−10³ PFU and n = 6 for doses 10 and 1 PFU; 10² PFU was done as two separate independent replicates with n = 3 for each) of ZIKV (A). All mice challenged with 10⁴−1 PFU succumbed 8 d PI. Young (n = 4) and adult mice (n = 6) were inoculated f.p. with 10⁵ PFU of ZIKV (B). Mice were monitored until day 10 PI. Changes in weight were calculated daily for ZIKV- and mock-infected mice (C). Error bars represent standard error of the mean.

doi: https://doi.org/10.1371/journal.pntd.0004682.g001