IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model
Fig 5
Effects of interleukin (IL) 33 deletion on group 2 innate lymphoid cells (ILC2) and neutrophil responses in lungs after resuscitated hemorrhagic shock and tissue trauma (HS/T).
The increase of ILC2 frequency (A) and the ILC2 IL5 expression (B) at 6 hours after HS/T was inhibited in IL33-/- mice (n = 5–8/group). C: The increase in neutrophil (Ly6G+CD11b+ gated from CD45+ cells) frequency after HS/T was not changed by IL33 deletion (n = 6–7/group). D: The increase of neutrophil IL5 expression (IL5+ gated from CD45+Ly6G+CD11b+ cells) at 6 hours after HS/T was inhibited in IL33-/- mice, compared with the C57BL/6 WT mice (n = 5–7/group). * P < 0.05. FSC-H, forward scatter-height.
doi: https://doi.org/10.1371/journal.pmed.1002365.g005