Literature that describes the prevalence of inherited red-green color deficiency in different populations is reviewed. Large random population surveys show that the prevalence of deficiency in European Caucasians is about 8% in men and about 0.4% in women and between 4% and 6.5% in men of Chinese and Japanese ethnicity. However, the male: female prevalence ratio is markedly different in Europeans and Asians. Recent surveys suggest that the prevalence is rising in men of African ethnicity and in geographic areas that have been settled by incoming migrants. It is proposed that founder events and genetic drift, rather than natural selection, are the cause of these differences.
Miguel A. Martínez-Domingo, Luis Gómez-Robledo, Eva M. Valero, Rafael Huertas, Javier Hernández-Andrés, Silvia Ezpeleta, and Enrique Hita Opt. Express 27(13) 17954-17967 (2019)
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Prevalence of Red-Green Color Deficiency Determined with the Ishihara Plates in European Caucasian Populations That Included More Than 1000 Men [5, 24, 25, 26, 27, 28]
Volunteers at a public science exhibition.
Obtained with the Bostrom Kugelberg and Bostrom II pseudoisochromatic plates.
Table 4.
Prevalence of Different Types of Red-Green Color Deficiency in European Men Obtained with the Nagel Anomaloscope [5,8,22,25,26,33]
Waaler 1927
725
0.88
1.04
1.03
5.01
8.07
0.32
Author/Year
Number of Color Deficient Men
% P
% PA
% D
% DA
TOTAL %
Protan: Deutan Ratio
Weiland 1933
85
0.96
1.16
0.96
5.12
8.20
0.35
Nelson 1938
180
1.27
1.20
1.27
5.08
8.82
0.39
François et al 1957
107
0.97
1.05
1.37
4.91
8.48
0.32
Koliopoulos et al. 1976
1687
1.00
1.20
1.14
4.61
7.95
0.38
Modarres et al. 1996 (Iran)
93
0.97
1.14
1.14
4.93
8.18
0.35
Table 5.
Expression of Red-Green Color Deficiency in Female Mixed Heterozygotes with a Gene for Protan Deficiency on One Chromosome and a Gene for Deutan Color Deficiency on the Other That Corresponds to a Prevalence Ratio in Men of 1 P: 1 PA: 1 D: 35 DA
Chromosome 2
Chromosome 1
P
PA
D
DA
P
1 P
1 PA
normal
normal
PA
1 PA
1 PA
normal
normal
D
normal
normal
1 D
5 DA
DA
normal
normal
5 DA
25 DA
Table 6.
Prevalence of Red-Ggreen Color Deficiency in Chinese Populations Determined with the Ishihara Plates (NB: place names are in Mandarin) [3,4,6,7,19,20,21]
Prevalence of Red-Green Color Deficiency Determined with the Ishihara Plates in European Caucasian Populations That Included More Than 1000 Men [5, 24, 25, 26, 27, 28]
Volunteers at a public science exhibition.
Obtained with the Bostrom Kugelberg and Bostrom II pseudoisochromatic plates.
Table 4.
Prevalence of Different Types of Red-Green Color Deficiency in European Men Obtained with the Nagel Anomaloscope [5,8,22,25,26,33]
Waaler 1927
725
0.88
1.04
1.03
5.01
8.07
0.32
Author/Year
Number of Color Deficient Men
% P
% PA
% D
% DA
TOTAL %
Protan: Deutan Ratio
Weiland 1933
85
0.96
1.16
0.96
5.12
8.20
0.35
Nelson 1938
180
1.27
1.20
1.27
5.08
8.82
0.39
François et al 1957
107
0.97
1.05
1.37
4.91
8.48
0.32
Koliopoulos et al. 1976
1687
1.00
1.20
1.14
4.61
7.95
0.38
Modarres et al. 1996 (Iran)
93
0.97
1.14
1.14
4.93
8.18
0.35
Table 5.
Expression of Red-Green Color Deficiency in Female Mixed Heterozygotes with a Gene for Protan Deficiency on One Chromosome and a Gene for Deutan Color Deficiency on the Other That Corresponds to a Prevalence Ratio in Men of 1 P: 1 PA: 1 D: 35 DA
Chromosome 2
Chromosome 1
P
PA
D
DA
P
1 P
1 PA
normal
normal
PA
1 PA
1 PA
normal
normal
D
normal
normal
1 D
5 DA
DA
normal
normal
5 DA
25 DA
Table 6.
Prevalence of Red-Ggreen Color Deficiency in Chinese Populations Determined with the Ishihara Plates (NB: place names are in Mandarin) [3,4,6,7,19,20,21]