eprintid: 1516136 rev_number: 44 eprint_status: archive userid: 608 dir: disk0/01/51/61/36 datestamp: 2017-01-26 10:10:17 lastmod: 2021-09-17 22:05:53 status_changed: 2017-04-24 10:15:00 type: article metadata_visibility: show creators_name: Malaspinas, A-S creators_name: Westaway, MC creators_name: Muller, C creators_name: Sousa, VC creators_name: Lao, O creators_name: Alves, I creators_name: Bergstrom, A creators_name: Athanasiadis, G creators_name: Cheng, JY creators_name: Crawford, JE creators_name: Heupink, TH creators_name: Macholdt, E creators_name: Peischl, S creators_name: Rasmussen, S creators_name: Schiffels, S creators_name: Subramanian, S creators_name: Wright, JL creators_name: Albrechtsen, A creators_name: Barbieri, C creators_name: Dupanloup, I creators_name: Eriksson, A creators_name: Margaryan, A creators_name: Moltke, I creators_name: Pugach, I creators_name: Korneliussen, TS creators_name: Levkivskyi, IP creators_name: Moreno-Mayar, JV creators_name: Ni, S creators_name: Racimo, F creators_name: Sikora, M creators_name: Xue, Y creators_name: Aghakhanian, FA creators_name: Brucato, N creators_name: Brunak, S creators_name: Campos, PF creators_name: Clark, W creators_name: Ellingvag, S creators_name: Fourmile, G creators_name: Gerbault, P creators_name: Injie, D creators_name: Koki, G creators_name: Leavesley, M creators_name: Logan, B creators_name: Lynch, A creators_name: Matisoo-Smith, EA creators_name: McAllister, PJ creators_name: Mentzer, AJ creators_name: Metspalu, M creators_name: Migliano, AB creators_name: Murgha, L creators_name: Phipps, ME creators_name: Pomat, W creators_name: Reynolds, D creators_name: Ricaut, F-X creators_name: Siba, P creators_name: Thomas, MG creators_name: Wales, T creators_name: Wall, CM creators_name: Oppenheimer, SJ creators_name: Tyler-Smith, C creators_name: Durbin, R creators_name: Dortch, J creators_name: Manica, A creators_name: Schierup, MH creators_name: Foley, RA creators_name: Lahr, MM creators_name: Bowern, C creators_name: Wall, JD creators_name: Mailund, T creators_name: Stoneking, M creators_name: Nielsen, R creators_name: Sandhu, MS creators_name: Excoffier, L creators_name: Lambert, DM creators_name: Willerslev, E title: A genomic history of Aboriginal Australia ispublished: pub divisions: UCL divisions: B02 divisions: C08 divisions: D09 divisions: F99 divisions: B03 divisions: C03 divisions: F22 keywords: Modern human dispersals, southeast-asia, neanderthal, ancestry, evolution, sequences, populations, europeans, admixture, african, Population genetics, Data processing, Anthropology, Genomics note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: The population history of Aboriginal Australians remains largely uncharacterized. Here we generate high-coverage genomes for 83 Aboriginal Australians (speakers of Pama–Nyungan languages) and 25 Papuans from the New Guinea Highlands. We find that Papuan and Aboriginal Australian ancestors diversified 25–40 thousand years ago (kya), suggesting pre-Holocene population structure in the ancient continent of Sahul (Australia, New Guinea and Tasmania). However, all of the studied Aboriginal Australians descend from a single founding population that differentiated ~10–32 kya. We infer a population expansion in northeast Australia during the Holocene epoch (past 10,000 years) associated with limited gene flow from this region to the rest of Australia, consistent with the spread of the Pama–Nyungan languages. We estimate that Aboriginal Australians and Papuans diverged from Eurasians 51–72 kya, following a single out-of-Africa dispersal, and subsequently admixed with archaic populations. Finally, we report evidence of selection in Aboriginal Australians potentially associated with living in the desert. date: 2016-10-13 date_type: published publisher: NATURE PUBLISHING GROUP official_url: http://doi.org/10.1038/nature18299 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green article_type_text: Article verified: verified_manual elements_id: 1159615 doi: 10.1038/nature18299 lyricists_name: Gerbault, Pascale lyricists_name: Migliano, Andrea lyricists_name: Thomas, Mark lyricists_id: PGERB91 lyricists_id: AMIGL66 lyricists_id: MTHOM52 actors_name: Thomas, Mark actors_id: MTHOM52 actors_role: owner full_text_status: public publication: Nature volume: 538 number: 7624 pagerange: 207-214 pages: 20 issn: 0028-0836 citation: Malaspinas, A-S; Westaway, MC; Muller, C; Sousa, VC; Lao, O; Alves, I; Bergstrom, A; ... Willerslev, E; + view all <#> Malaspinas, A-S; Westaway, MC; Muller, C; Sousa, VC; Lao, O; Alves, I; Bergstrom, A; Athanasiadis, G; Cheng, JY; Crawford, JE; Heupink, TH; Macholdt, E; Peischl, S; Rasmussen, S; Schiffels, S; Subramanian, S; Wright, JL; Albrechtsen, A; Barbieri, C; Dupanloup, I; Eriksson, A; Margaryan, A; Moltke, I; Pugach, I; Korneliussen, TS; Levkivskyi, IP; Moreno-Mayar, JV; Ni, S; Racimo, F; Sikora, M; Xue, Y; Aghakhanian, FA; Brucato, N; Brunak, S; Campos, PF; Clark, W; Ellingvag, S; Fourmile, G; Gerbault, P; Injie, D; Koki, G; Leavesley, M; Logan, B; Lynch, A; Matisoo-Smith, EA; McAllister, PJ; Mentzer, AJ; Metspalu, M; Migliano, AB; Murgha, L; Phipps, ME; Pomat, W; Reynolds, D; Ricaut, F-X; Siba, P; Thomas, MG; Wales, T; Wall, CM; Oppenheimer, SJ; Tyler-Smith, C; Durbin, R; Dortch, J; Manica, A; Schierup, MH; Foley, RA; Lahr, MM; Bowern, C; Wall, JD; Mailund, T; Stoneking, M; Nielsen, R; Sandhu, MS; Excoffier, L; Lambert, DM; Willerslev, E; - view fewer <#> (2016) A genomic history of Aboriginal Australia. Nature , 538 (7624) pp. 207-214. 10.1038/nature18299 . Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1516136/1/Thomas_Australia_RPS.pdf