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- Tissue inhibitors of metalloproteinases (TIMPs) are specific endogenous protease inhibitors to the matrix metalloproteinases. There are four TIMPs; TIMP1, TIMP2, TIMP3 and TIMP4. TIMP3 has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. For this reason, TIMP3 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression. Overall, all MMPs are inhibited by TIMPs once they are activated but the gelatinases (MMP-2 and MMP-9) can form complexes with TIMPs when the enzymes are in the latent form. The complex of latent MMP-2 (pro-MMP-2)with TIMP-2 serves to facilitate the activation of pro-MMP-2 at the cell surface by MT1-MMP (MMP-14), a membrane-anchored MMP. The role of the pro-MMP-9/TIMP-1 complex is still unknown. (en)
- As metaloproteinases de matriz são inibidas por inibidores teciduais de metaloproteinases ( também chamados de TIMPs), específicos e endógenos, constituindo uma família de 4 inibidores de protease: TIMP1, TIMP2, TIMP3 e TIMP4. De forma geral, todas as MMPs são passíveis de inibição por TIMPs uma vez ativadas. As gelatinases (MMP-2 e MMP-9), no entanto, podem formar complexos com TIMPs enquanto as enzimas ainda se encontram na forma latente. A complexação de MMP-2 latente (pro-MMP-2) com TIMP-2 facilita a ativação de pro-MMP-2 na superfície celular por MT1-MMP (MMP-14), uma MMP ancorada à membrana. O papel do complexo pro-MMP-9/TIMP-1 é ainda desconhecido. (pt)
- Тканевые или эндогенные ингибиторы металлопротеиназ (TIMP) — семейство молекул, снижающих активность металлопротеиназ внеклеточного матрикса. У человека известно четыре эндогенных ингибитора металлопротеиназ — TIMP1, , , . (ru)
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- Тканевые или эндогенные ингибиторы металлопротеиназ (TIMP) — семейство молекул, снижающих активность металлопротеиназ внеклеточного матрикса. У человека известно четыре эндогенных ингибитора металлопротеиназ — TIMP1, , , . (ru)
- Tissue inhibitors of metalloproteinases (TIMPs) are specific endogenous protease inhibitors to the matrix metalloproteinases. There are four TIMPs; TIMP1, TIMP2, TIMP3 and TIMP4. TIMP3 has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. For this reason, TIMP3 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression. (en)
- As metaloproteinases de matriz são inibidas por inibidores teciduais de metaloproteinases ( também chamados de TIMPs), específicos e endógenos, constituindo uma família de 4 inibidores de protease: TIMP1, TIMP2, TIMP3 e TIMP4. De forma geral, todas as MMPs são passíveis de inibição por TIMPs uma vez ativadas. As gelatinases (MMP-2 e MMP-9), no entanto, podem formar complexos com TIMPs enquanto as enzimas ainda se encontram na forma latente. O papel do complexo pro-MMP-9/TIMP-1 é ainda desconhecido. (pt)
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- Inibidor tecidual de metaloproteinase (pt)
- Tissue inhibitor of metalloproteinase (en)
- Эндогенные ингибиторы металлопротеиназ (ru)
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