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- The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases. As the first member of this family to be characterised was Drosophila alcohol dehydrogenase, this family used to be called 'insect-type', or 'short-chain' alcohol dehydrogenases. Most members of this family are proteins of about 250 to 300 amino acid residues. Most dehydrogenases possess at least 2 domains, the first binding the coenzyme, often NAD, and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis. Little sequence similarity has been found in the coenzyme binding domain although there is a large degree of structural similarity, and it has therefore been suggested that the structure of dehydrogenases has arisen through gene fusion of a common ancestral coenzyme nucleotide sequence with various substrate specific domains. (en)
- 短链脱氢酶（英語：Short-chain dehydrogenase，或称为短链脱氢/还原酶家族，英語：short-chain dehydrogenases/reductases family，缩写SDR）是一个非常大的蛋白质家族，属于 NAD- 或 NADP-依赖的氧化還原酶，第一个被鉴定的家族成员是黑腹果蝇的醇脱氢酶，因此命名为“昆虫型”（'insect-type'）或“短链”（'short-chain'）醇脱氢酶。大部分酶家族成员有250到300个氨基酸残基，且包含至少两个结构域其中一个用于结合辅酶，大部分是NAD，少部分是NADP，另一个用于结合及催化。 (zh)
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- 4775 (xsd:nonNegativeInteger)
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- short chain dehydrogenase (en)
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- 短链脱氢酶（英語：Short-chain dehydrogenase，或称为短链脱氢/还原酶家族，英語：short-chain dehydrogenases/reductases family，缩写SDR）是一个非常大的蛋白质家族，属于 NAD- 或 NADP-依赖的氧化還原酶，第一个被鉴定的家族成员是黑腹果蝇的醇脱氢酶，因此命名为“昆虫型”（'insect-type'）或“短链”（'short-chain'）醇脱氢酶。大部分酶家族成员有250到300个氨基酸残基，且包含至少两个结构域其中一个用于结合辅酶，大部分是NAD，少部分是NADP，另一个用于结合及催化。 (zh)
- The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases. As the first member of this family to be characterised was Drosophila alcohol dehydrogenase, this family used to be called 'insect-type', or 'short-chain' alcohol dehydrogenases. Most members of this family are proteins of about 250 to 300 amino acid residues. Most dehydrogenases possess at least 2 domains, the first binding the coenzyme, often NAD, and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis. Little sequence similarity has been found in the coenzyme binding domain although there is a large degree of structural similarity, and it has the (en)
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- Short-chain dehydrogenase (en)
- 短链脱氢酶 (zh)
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