Progesterone devices are broadly used in the control of reproductive management in livestock. They work by increasing circulating plasma progesterone levels with the following consequences: 1. * Progesterone suppresses the secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus. This is done via a negative feedback to the hypothalamus neuroendocrine cells, by inhibition of KiSSpeptin KiSS1-derived peptide receptor, a protein needed for the release of GnRH. 2. * Low levels of GnRH prevent the emergence of a dominant follicle by reducing the release of LH and FSH hormones. Current follicular waves cease and a new wave emerges 3–5 days after implant. 3. * A dominant follicle develops but there is no ovulation as LH release is prevented by suppression of GnRH. 4. * Rem
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