About: Polo-like kinase

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Polo-like kinases (Plks) are regulatory serine/threonin kinases of the cell cycle involved in mitotic entry, mitotic exit, spindle formation, cytokinesis, and meiosis. Only one Plk is found in the genomes of the fly Drosophila melanogaster (Polo), budding yeast (Cdc5) and fission yeast (Plo1). Vertebrates and other animals, however, have many Plk family members including Plk1 (Xenopus Plx1), Plk2/Snk (Xenopus Plx2), Plk3/Prk/FnK (Xenopus Plx3), Plk4/Sak and Plk5. Of the vertebrate Plk family members, the mammalian Plk1 has been most extensively studied. During mitosis and cytokinesis, Plks associate with several structures including the centrosome, kinetochores, and the central spindle.

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  • Polo-like kinases (Plks) are regulatory serine/threonin kinases of the cell cycle involved in mitotic entry, mitotic exit, spindle formation, cytokinesis, and meiosis. Only one Plk is found in the genomes of the fly Drosophila melanogaster (Polo), budding yeast (Cdc5) and fission yeast (Plo1). Vertebrates and other animals, however, have many Plk family members including Plk1 (Xenopus Plx1), Plk2/Snk (Xenopus Plx2), Plk3/Prk/FnK (Xenopus Plx3), Plk4/Sak and Plk5. Of the vertebrate Plk family members, the mammalian Plk1 has been most extensively studied. During mitosis and cytokinesis, Plks associate with several structures including the centrosome, kinetochores, and the central spindle. (en)
  • ポロ様キナーゼ（ポロようキナーゼ、英: Polo-like kinase、略称: Plk）は細胞周期を調節するセリン/スレオニンキナーゼであり、有糸分裂の開始、終結、紡錘体の形成、細胞質分裂、減数分裂に関与する。Plkはショウジョウバエ、出芽酵母、分裂酵母のゲノムには1つしかコードされていないが（それぞれPolo、Cdc5、Plo1）、脊椎動物ではPlk1（ツメガエルではPlx1）、（Plx2）、（Plx3）、、Plk5を含む、多数のPlkファミリーのメンバーが存在する。Plkファミリーのメンバーの中では、哺乳類のPlk1が最も広く研究されている。有糸分裂と細胞質分裂の間、Plkは中心体、キネトコア、を含むいくつかの構造体と結合している。 (ja)
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  • Polo-like kinases (Plks) are regulatory serine/threonin kinases of the cell cycle involved in mitotic entry, mitotic exit, spindle formation, cytokinesis, and meiosis. Only one Plk is found in the genomes of the fly Drosophila melanogaster (Polo), budding yeast (Cdc5) and fission yeast (Plo1). Vertebrates and other animals, however, have many Plk family members including Plk1 (Xenopus Plx1), Plk2/Snk (Xenopus Plx2), Plk3/Prk/FnK (Xenopus Plx3), Plk4/Sak and Plk5. Of the vertebrate Plk family members, the mammalian Plk1 has been most extensively studied. During mitosis and cytokinesis, Plks associate with several structures including the centrosome, kinetochores, and the central spindle. (en)
  • ポロ様キナーゼ（ポロようキナーゼ、英: Polo-like kinase、略称: Plk）は細胞周期を調節するセリン/スレオニンキナーゼであり、有糸分裂の開始、終結、紡錘体の形成、細胞質分裂、減数分裂に関与する。Plkはショウジョウバエ、出芽酵母、分裂酵母のゲノムには1つしかコードされていないが（それぞれPolo、Cdc5、Plo1）、脊椎動物ではPlk1（ツメガエルではPlx1）、（Plx2）、（Plx3）、、Plk5を含む、多数のPlkファミリーのメンバーが存在する。Plkファミリーのメンバーの中では、哺乳類のPlk1が最も広く研究されている。有糸分裂と細胞質分裂の間、Plkは中心体、キネトコア、を含むいくつかの構造体と結合している。 (ja)
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  • ポロ様キナーゼ (ja)
  • Polo-like kinase (en)
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