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- La proteasa similar a la papaína (Papain-like Protease o PLpro''') es una cisteína proteasa esencial para la replicación del coronavirus que pertenece al grupo de peptidasas CA (familia C16). La función primordial de la proteasa similar a la papaína (PLpro) es procesar la poliproteína viral de manera coordinada. No obstante, la PLpro tiene una función adicional que consiste en remover la ubiquitina i la ISG15 de las proteínas de la célula huésped con el fin de ayudar a la evasión del coronavirus. Por estos motivos la PLpro es una diana terapéutica en la investigación de fármacos antivirales contra el SARS-CoV. (es)
- Papain-like proteases (or papain-like (cysteine) peptidases; abbreviated PLP or PLCP) are a large protein family of cysteine protease enzymes that share structural and enzymatic properties with the group's namesake member, papain. They are found in all domains of life. In animals, the group is often known as cysteine cathepsins or, in older literature, lysosomal peptidases. In the MEROPS protease enzyme classification system, papain-like proteases form Clan CA. Papain-like proteases share a common catalytic dyad active site featuring a cysteine amino acid residue that acts as a nucleophile. The human genome encodes eleven cysteine cathepsins which have a broad range of physiological functions. In some parasites papain-like proteases have roles in host invasion, such as cruzipain from Trypanosoma cruzi. In plants, they are involved in host defense and in development. Studies of papain-like proteases from prokaryotes have lagged their eukaryotic counterparts. In cellular organisms they are synthesized as preproenzymes that are not enzymatically active until mature, and their activities are tightly regulated, often by the presence of endogenous protease inhibitors such as cystatins. In many RNA viruses, including significant human pathogens such as the coronaviruses SARS-CoV and SARS-CoV-2, papain-like protease protein domains often have roles in processing of polyproteins into mature viral nonstructural proteins. Many papain-like proteases are considered potential drug targets. (en)
- パパイン様プロテアーゼ（パパインようプロテアーゼ、英: papain-like protease、PLpro）は、コロナウイルスの複製に不可欠なシステインプロテアーゼで、CAグループペプチダーゼ（C16ファミリー）に属する。パパイン様プロテアーゼ（PLpro）の主な機能は、ウイルスのを協調して処理することである。ただし、PLproには、コロナウイルスの回避を助けるために、宿主細胞のタンパク質からユビキチンとを除去するという付加的な機能がある。これらの理由から、PLproはSARS-CoVに対する抗ウイルス剤の研究における治療標的となっている。 (ja)
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- Papain, the family's namesake member, from Carica papaya (en)
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- La proteasa similar a la papaína (Papain-like Protease o PLpro''') es una cisteína proteasa esencial para la replicación del coronavirus que pertenece al grupo de peptidasas CA (familia C16). La función primordial de la proteasa similar a la papaína (PLpro) es procesar la poliproteína viral de manera coordinada. No obstante, la PLpro tiene una función adicional que consiste en remover la ubiquitina i la ISG15 de las proteínas de la célula huésped con el fin de ayudar a la evasión del coronavirus. Por estos motivos la PLpro es una diana terapéutica en la investigación de fármacos antivirales contra el SARS-CoV. (es)
- パパイン様プロテアーゼ（パパインようプロテアーゼ、英: papain-like protease、PLpro）は、コロナウイルスの複製に不可欠なシステインプロテアーゼで、CAグループペプチダーゼ（C16ファミリー）に属する。パパイン様プロテアーゼ（PLpro）の主な機能は、ウイルスのを協調して処理することである。ただし、PLproには、コロナウイルスの回避を助けるために、宿主細胞のタンパク質からユビキチンとを除去するという付加的な機能がある。これらの理由から、PLproはSARS-CoVに対する抗ウイルス剤の研究における治療標的となっている。 (ja)
- Papain-like proteases (or papain-like (cysteine) peptidases; abbreviated PLP or PLCP) are a large protein family of cysteine protease enzymes that share structural and enzymatic properties with the group's namesake member, papain. They are found in all domains of life. In animals, the group is often known as cysteine cathepsins or, in older literature, lysosomal peptidases. In the MEROPS protease enzyme classification system, papain-like proteases form Clan CA. Papain-like proteases share a common catalytic dyad active site featuring a cysteine amino acid residue that acts as a nucleophile. (en)
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- Proteasa similar a la papaína (es)
- パパイン様プロテアーゼ (ja)
- Papain-like protease (en)
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