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- Mason-Pfizer monkey virus (M-PMV), formerly Simian retrovirus (SRV), is a species of retroviruses that usually infect and cause a fatal immune deficiency in Asian macaques. The ssRNA virus appears sporadically in mammary carcinoma of captive macaques at breeding facilities which expected as the natural host, but the prevalence of this virus in feral macaques remains unknown. M-PMV was transmitted naturally by virus-containing body fluids (saliva, urine, blood, etc.), via biting, scratching, grooming, and fighting. Cross contaminated instruments or equipment (fomite) can also spread this virus among animals. Some clinical and pathological symptoms of M-PMV-infected newborn rhesus macaques are diarrhea, weight loss, splenomegaly, lymphadenopathy, anemia, neutropenia, and neoplastic diseases (retroperitoneal fibromatosis or rare B-cell lymphomas). Infected new-born Rhesus monkeys may develop immunodeficiency disease accompanied by opportunistic infections. To prevent the infection of this virus, two vaccinations have been developed. Those two effective vaccinations are formalin-inactivated whole SRV-1 vaccine and recombinant vaccine expressing M-PMV envelope glycoprotein gp70 and gp22. M-PMV-based vector is a candidate for delivering therapeutic genes in human gene transfer. Based on the M-PMV 1) promoter region remain transcriptionally active in human cells and 2) the constitutive transport element (CTE) expression in the target cells aids the facilitation of the nuclear export for the gene therapy. (en)
- Simian Retrovirus (SRV) adalah virus dari famili Retroviridae yang umum menyerang primata. Virus ini ditemukan pertama kali antara tahun 1981-1983 sebagai penyebab sindrom imunosupresif yang diderita banyak primata di New England Primate Research Center (NEPRC) dan California Regional Primate Centres (CRPC), Amerika Serikat. Sampai saat ini telah ditemukan tiga jenis SRV, yaitu SRV-1, SRV-2, dan SRV-3. Virus SRV-1 tidak berkerabat dekat dengan HIV-1, namun memiliki kemiripan dengan Mason Pfizer monkey virus (MPMV) yang diisolasi dari sel tumor payudara monyet betina. Sementara itu, SRV-2 ditemukan pada spesies primata M. nemestrina dan memiliki kekerabatan yang cukup jauh dibandingkan dengan SRV-1 dan MPMV (SRV-3). (in)
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- 20754 (xsd:nonNegativeInteger)
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- Predicted secondary structure and sequence conservation of MPMV_package (en)
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- Q18862723 (en)
- Q7517774 (en)
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- Mason-Pfizer monkey virus packaging signal (en)
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- Mason-Pfizer monkey virus (en)
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- * Mason–Pfizer monkey virus
* Simian retrovirus 1
* Simian retrovirus 2 (en)
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- * Simian retrovirus
* Simian type D virus 1 (en)
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- Simian Retrovirus (SRV) adalah virus dari famili Retroviridae yang umum menyerang primata. Virus ini ditemukan pertama kali antara tahun 1981-1983 sebagai penyebab sindrom imunosupresif yang diderita banyak primata di New England Primate Research Center (NEPRC) dan California Regional Primate Centres (CRPC), Amerika Serikat. Sampai saat ini telah ditemukan tiga jenis SRV, yaitu SRV-1, SRV-2, dan SRV-3. Virus SRV-1 tidak berkerabat dekat dengan HIV-1, namun memiliki kemiripan dengan Mason Pfizer monkey virus (MPMV) yang diisolasi dari sel tumor payudara monyet betina. Sementara itu, SRV-2 ditemukan pada spesies primata M. nemestrina dan memiliki kekerabatan yang cukup jauh dibandingkan dengan SRV-1 dan MPMV (SRV-3). (in)
- Mason-Pfizer monkey virus (M-PMV), formerly Simian retrovirus (SRV), is a species of retroviruses that usually infect and cause a fatal immune deficiency in Asian macaques. The ssRNA virus appears sporadically in mammary carcinoma of captive macaques at breeding facilities which expected as the natural host, but the prevalence of this virus in feral macaques remains unknown. M-PMV was transmitted naturally by virus-containing body fluids (saliva, urine, blood, etc.), via biting, scratching, grooming, and fighting. Cross contaminated instruments or equipment (fomite) can also spread this virus among animals. (en)
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- Simian retrovirus Type D (SRV) (in)
- Mason-Pfizer monkey virus (en)
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