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- Licofelone is a dual COX/LOX inhibitor that was studied in clinical trials as a treatment for osteoarthritis and which was under development by Merckle GmbH with partners Alfa Wassermann and Lacer. Licofelone is both an analgesic and an anti-inflammatory. Inhibition of 5-lipoxygenase (5-LOX) may reduce the gastrointestinal toxicity associated with other nonsteroidal anti-inflammatory drugs (NSAID), which only inhibit cyclooxygenase (COX). Licofelone is the first drug to inhibit both. Phase III trials for osteoarthritis were conducted in the early 2000s, but results were mixed and the drug has never been submitted for regulatory approval. (en)
- Licofelone (conosciuto anche in fase sperimentale con la sigla ML 3000) è una molecola appartenente alla classe dei farmaci antinfiammatori non steroidei (FANS). La molecola deriva dall'acido acetico ed è dotata di proprietà antinfiammatorie, antipiretiche, analgesiche e di antiaggregazione piastrinica. Il farmaco è stato sviluppato da un consorzio denominato EuroAlliance e formato dalla società farmaceutica italiana , da Merckle GmbH, e da Lacer SA. (it)
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- 5113 (xsd:nonNegativeInteger)
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- [6--2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid (en)
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- UAWXGRJVZSAUSZ-UHFFFAOYSA-N (en)
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- Licofelone (conosciuto anche in fase sperimentale con la sigla ML 3000) è una molecola appartenente alla classe dei farmaci antinfiammatori non steroidei (FANS). La molecola deriva dall'acido acetico ed è dotata di proprietà antinfiammatorie, antipiretiche, analgesiche e di antiaggregazione piastrinica. Il farmaco è stato sviluppato da un consorzio denominato EuroAlliance e formato dalla società farmaceutica italiana , da Merckle GmbH, e da Lacer SA. (it)
- Licofelone is a dual COX/LOX inhibitor that was studied in clinical trials as a treatment for osteoarthritis and which was under development by Merckle GmbH with partners Alfa Wassermann and Lacer. Licofelone is both an analgesic and an anti-inflammatory. Inhibition of 5-lipoxygenase (5-LOX) may reduce the gastrointestinal toxicity associated with other nonsteroidal anti-inflammatory drugs (NSAID), which only inhibit cyclooxygenase (COX). Licofelone is the first drug to inhibit both. (en)
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- Licofelone (it)
- Licofelone (en)
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