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- The gastric mucosal barrier is the property of the stomach that allows it to safely contain the gastric acid required for digestion. If the barrier is broken, as by acetylsalicylic acid (ASA, aspirin) in acid solution, acid diffuses back into the mucosa where it can cause damage to the stomach itself. The barrier consists of three protective components. These provide the additional resistance for the mucosal surface of the stomach. The three components include:
* A compact epithelial cell lining. Cells in the epithelium of the stomach are bound by tight junctions that repel harsh fluids that may injure the stomach lining.
* A special mucus covering, derived from mucus secreted by surface epithelial cells and Foveolar cells. This insoluble mucus forms a protective gel-like coating over the entire surface of the gastric mucosa. The mucus protects the gastric mucosa from autodigestion by e.g. pepsin and from erosion by acids and other caustic materials that are ingested.
* Bicarbonate ions, secreted by the surface epithelial cells. The bicarbonate ions act to neutralize harsh acids. (en)
- La barriera mucosa gastrica consiste in uno strato mucoso di circa 0,2 mm che ricopre la tonaca mucosa dello stomaco; lo scopo di questa barriera è proteggere l'epitelio gastrico dall'azione lesiva dell'HCl prodotto dalle cellule parietali dello stomaco.Essa deriva dalla produzione da parte delle cellule superficiali gastriche di goccioline di mucoproteine ad alto peso molecolare (quindi molto viscose) e dalla produzione di bicarbonato. (it)
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- La barriera mucosa gastrica consiste in uno strato mucoso di circa 0,2 mm che ricopre la tonaca mucosa dello stomaco; lo scopo di questa barriera è proteggere l'epitelio gastrico dall'azione lesiva dell'HCl prodotto dalle cellule parietali dello stomaco.Essa deriva dalla produzione da parte delle cellule superficiali gastriche di goccioline di mucoproteine ad alto peso molecolare (quindi molto viscose) e dalla produzione di bicarbonato. (it)
- The gastric mucosal barrier is the property of the stomach that allows it to safely contain the gastric acid required for digestion. If the barrier is broken, as by acetylsalicylic acid (ASA, aspirin) in acid solution, acid diffuses back into the mucosa where it can cause damage to the stomach itself. The barrier consists of three protective components. These provide the additional resistance for the mucosal surface of the stomach. The three components include: (en)
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- Gastric mucosal barrier (en)
- Barriera mucosa gastrica (it)
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