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- Die Dihydropteroat-Synthase (DHPS) ist ein Enzym, das im Folsäure-Stoffwechsel von Bakterien, Pilzen und Pflanzen vorkommt, nicht aber in Tieren. In Archaeen ist die Dihydropteroat-Synthase an der Biosynthese von beteiligt. In Tieren wird Folsäure nicht hergestellt und ist ein Vitamin, das über die Nahrung zugeführt werden muss. (de)
- Dihydropteroate synthase is an enzyme classified under EC 2.5.1.15. It produces dihydropteroate in bacteria, but it is not expressed in most eukaryotes including humans. This makes it a useful target for sulfonamide antibiotics, which compete with the PABA precursor.
* (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate (PABA) diphosphate + dihydropteroate. All organisms require reduced folate cofactors for the synthesis of a variety of metabolites. Most microorganisms must synthesize folate de novo because they lack the active transport system of higher vertebrate cells that allows these organisms to use dietary folates. Proteins containing this domain include dihydropteroate synthase (EC 2.5.1.15) as well as a group of methyltransferase enzymes including methyltetrahydrofolate, corrinoid iron-sulphur protein methyltransferase (MeTr) that catalyses a key step in the Wood-Ljungdahl pathway of carbon dioxide fixation. Dihydropteroate synthase (EC 2.5.1.15) (DHPS) catalyses the condensation of 6-hydroxymethyl-7,8-dihydropteridine pyrophosphate to para-aminobenzoic acid to form 7,8-dihydropteroate. This is the second step in the three-step pathway leading from 6-hydroxymethyl-7,8-dihydropterin to 7,8-dihydrofolate. DHPS is the target of sulfonamides, which are substrate analogues that compete with para-aminobenzoic acid. Bacterial DHPS (gene sul or folP) is a protein of about 275 to 315 amino acid residues that is either chromosomally encoded or found on various antibiotic resistance plasmids. In the fungus Pneumocystis jirovecii (previously P. carinii) DHPS is the C-terminal domain of a multifunctional folate synthesis enzyme (gene fas). (en)
- La dihydroptéroate synthase est une enzyme classée par la nomenclature EC en tant que 2.5.1.15, présente dans la biosynthèse de la tétrahydrométhanoptérine chez les archées et de l’acide folique chez les bactéries, les champignons et les plantes, mais pas chez les animaux. (fr)
- La diidropteroato-sintetasi (THF-A) (EC 2.5.1.15) è un enzima necessario per la produzione dell'acido diidropteroico un precursore dell'acido tetraidrofolico fondamentale per la replicazione batterica. L'enzima utilizza come substrato l'acido p-amminobenzoico (PABA). La diidropteroato-sintetasi è espressa nei batteri, ma non è espressa in molti eucarioti tra cui l'uomo, per questo motivo può essere impiegata come bersaglio per la terapia antibatterica. I sulfamidici sono agenti batteriostatici che competono con il PABA per il sito attivo dell'enzima, possono essere impiegati nella terapia delle infezioni urinarie, enteriti o colite ulcerosa. (it)
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- 4160 (xsd:nonNegativeInteger)
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- Tetrahydrofolate synthesis pathway (en)
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- Dihydropteroate synthetase (en)
- Pterin binding enzyme (en)
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- A:28-230 A:28-230 B:28-230
A:28-230 A:28-230 B:9-210
A:9-210 A:11-220 :20-228
:20-228 :20-228 A:509-774
B:315-515 B:315-515 A:315-515
A:315-515 B:315-515 A:315-515
A:1-206 (en)
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- Die Dihydropteroat-Synthase (DHPS) ist ein Enzym, das im Folsäure-Stoffwechsel von Bakterien, Pilzen und Pflanzen vorkommt, nicht aber in Tieren. In Archaeen ist die Dihydropteroat-Synthase an der Biosynthese von beteiligt. In Tieren wird Folsäure nicht hergestellt und ist ein Vitamin, das über die Nahrung zugeführt werden muss. (de)
- La dihydroptéroate synthase est une enzyme classée par la nomenclature EC en tant que 2.5.1.15, présente dans la biosynthèse de la tétrahydrométhanoptérine chez les archées et de l’acide folique chez les bactéries, les champignons et les plantes, mais pas chez les animaux. (fr)
- Dihydropteroate synthase is an enzyme classified under EC 2.5.1.15. It produces dihydropteroate in bacteria, but it is not expressed in most eukaryotes including humans. This makes it a useful target for sulfonamide antibiotics, which compete with the PABA precursor.
* (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate (PABA) diphosphate + dihydropteroate. (en)
- La diidropteroato-sintetasi (THF-A) (EC 2.5.1.15) è un enzima necessario per la produzione dell'acido diidropteroico un precursore dell'acido tetraidrofolico fondamentale per la replicazione batterica. L'enzima utilizza come substrato l'acido p-amminobenzoico (PABA). (it)
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| rdfs:label
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- Dihydropteroat-Synthase (de)
- Dihydropteroate synthase (en)
- Dihydroptéroate synthase (fr)
- Diidropteroato sintetasi (it)
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- Dihydropteroate synthetase (en)
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