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- Cysteine dioxygenase (CDO) is a non-heme iron enzyme that catalyzes the conversion of L-cysteine to cysteine sulfinic acid (cysteine sulfinate). CDO plays an important role in cysteine catabolism, regulating intracellular levels of cysteine and responding changes in cysteine availability. As such, CDO is highly regulated and undergoes large changes in concentration and efficiency. It oxidizes cysteine to the corresponding sulfinic acid by activation of dioxygen, although the exact mechanism of the reaction is still unclear. In addition to being found in mammals, CDO also exists in some yeast and bacteria, although the exact function is still unknown. CDO has been implicated in various neurodegenerative diseases and cancers, which is likely related to cysteine toxicity. (en)
- La cystéine dioxygénase est une oxydoréductase qui catalyse la réaction : L-cystéine + O2 3-sulfino-L-alanine. La 3-sulfinoalanine, encore appelée acide cystéine-sulfinique, se trouve à un carrefour du catabolisme de la cystéine, pouvant conduire alternativement à la taurine ou au sulfate. La voie de la taurine conduit préalablement à l'hypotaurine, qui est par la suite oxydée en taurine. La voie du sulfate conduit préalablement au , qui se décompose en pyruvate et sulfite. (fr)
- La cisteina diossigenasi (CDO) è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la conversione della L-cisteina in incorporando ossigeno.L'enzima richiede come cofattori Fe2+ e NAD(P)H. schema di reazione che illustra la formazione di acido cistein-solfonico a partire da cisteina per aggiunta di ossigeno (it)
- システインジオキシゲナーゼ（cysteine dioxygenase）は、L-システインを酸素分子の組み込みによってシステインスルフィン酸に酸化する非ヘム鉄酵素である。 システインスルフィン酸はシステイン異化の分岐点に位置し、ここからタウリン合成と硫酸塩合成の2種の経路を辿る。タウリン代謝のシステインスルフィン酸依存経路ではヒポタウリンが合成される。ヒポタウリンは後にタウリンに酸化される。また、システインスルフィン酸はアミノ基転移を受け、となり、ピルビン酸と亜硫酸に分解する。 (ja)
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- 16042 (xsd:nonNegativeInteger)
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- Cysteine dioxygenase 1, monomer, Human (en)
- Human CDO (en)
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- Cysteine dioxygenase (en)
- cysteine dioxygenase, type I (en)
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- Cysteine dioxygenase (CDO) is a non-heme iron enzyme that catalyzes the conversion of L-cysteine to cysteine sulfinic acid (cysteine sulfinate). CDO plays an important role in cysteine catabolism, regulating intracellular levels of cysteine and responding changes in cysteine availability. As such, CDO is highly regulated and undergoes large changes in concentration and efficiency. It oxidizes cysteine to the corresponding sulfinic acid by activation of dioxygen, although the exact mechanism of the reaction is still unclear. In addition to being found in mammals, CDO also exists in some yeast and bacteria, although the exact function is still unknown. CDO has been implicated in various neurodegenerative diseases and cancers, which is likely related to cysteine toxicity. (en)
- La cystéine dioxygénase est une oxydoréductase qui catalyse la réaction : L-cystéine + O2 3-sulfino-L-alanine. La 3-sulfinoalanine, encore appelée acide cystéine-sulfinique, se trouve à un carrefour du catabolisme de la cystéine, pouvant conduire alternativement à la taurine ou au sulfate. La voie de la taurine conduit préalablement à l'hypotaurine, qui est par la suite oxydée en taurine. La voie du sulfate conduit préalablement au , qui se décompose en pyruvate et sulfite. (fr)
- La cisteina diossigenasi (CDO) è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la conversione della L-cisteina in incorporando ossigeno.L'enzima richiede come cofattori Fe2+ e NAD(P)H. schema di reazione che illustra la formazione di acido cistein-solfonico a partire da cisteina per aggiunta di ossigeno (it)
- システインジオキシゲナーゼ（cysteine dioxygenase）は、L-システインを酸素分子の組み込みによってシステインスルフィン酸に酸化する非ヘム鉄酵素である。 システインスルフィン酸はシステイン異化の分岐点に位置し、ここからタウリン合成と硫酸塩合成の2種の経路を辿る。タウリン代謝のシステインスルフィン酸依存経路ではヒポタウリンが合成される。ヒポタウリンは後にタウリンに酸化される。また、システインスルフィン酸はアミノ基転移を受け、となり、ピルビン酸と亜硫酸に分解する。 (ja)
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| rdfs:label
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- Cysteine dioxygenase (en)
- Cisteina diossigenasi (it)
- Cystéine dioxygénase (fr)
- システインジオキシゲナーゼ (ja)
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- Cysteine dioxygenase (en)
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