| dbo:abstract
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- Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system. It serves a number of critical functions in immunity, tolerance, and autoimmunity with the other numerous components. Furthermore, it is a crucial factor in connecting the recognition pathways of the overall system instigated by antibody-antigen (Ab-Ag) complexes to the other effector proteins of the innate immune response. For example, the severity of a dysfunctional complement system can lead to fatal diseases and infections. Complex variations of it can also lead to schizophrenia. The C4 protein was thought to derive from a simple two-locus allelic model, which however has been replaced by a much more sophisticated multimodular RCCX gene complex model which contain long and short forms of the C4A or C4B genes usually in tandem RCCX cassettes with copy number variation, that somewhat parallels variation in the levels of their respective proteins within a population along with CYP21 in some cases depending on the number of cassettes and whether it contains the functional gene instead of pseudogenes or fragments. Originally defined in the context of the Chido/Rodgers blood group system, the C4A-C4B genetic model is under investigation for its possible role in schizophrenia risk and development. (en)
- Komponen komplemen 4 (bahasa Inggris: pro-c4) adalah sebuah glikoprotein yang berperan pada aktivasi . C4 teraktivasi saat terjadi ikatan antara antibodi dengan molekul target tertentu, dan teriris oleh menjadi dan . C4d merupakan degradasi dari C4. Setelah aktivasi dan degradasi molekul C4, gugus tio-ester akan tampak dan memungkinkan ikatan antara C4d dengan permukaan sel endotelial dan . C4d juga ditemukan pada intracytoplasmic vacuoles pada sel endotelial. Deteksi C4d dianggap merupakan pertanda tidak langsung dari respon antibodi. (in)
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| dbo:arm
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| dbo:band
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| dbo:chromosome
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| dbo:entrezgene
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| dbo:hgncid
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| dbo:omim
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- 120810 (xsd:integer)
- 120820 (xsd:integer)
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| dbo:refseq
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| dbo:symbol
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| dbo:thumbnail
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| dbo:uniprot
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| dbo:wikiPageExternalLink
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| dbo:wikiPageLength
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- 35904 (xsd:nonNegativeInteger)
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| dbo:wikiPageRevisionID
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| dbp:arm
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| dbp:band
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| dbp:chromosome
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| dbp:entrezgene
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- 720 (xsd:integer)
- 721 (xsd:integer)
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| dbp:hgncid
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- 1323 (xsd:integer)
- 1324 (xsd:integer)
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| dbp:name
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| dbp:omim
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- 120810 (xsd:integer)
- 120820 (xsd:integer)
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| dbp:refseq
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- NM_000592 (en)
- NM_007293 (en)
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| dbp:symbol
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| dbp:wikiPageUsesTemplate
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| dcterms:subject
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| gold:hypernym
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| rdf:type
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| rdfs:comment
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- Komponen komplemen 4 (bahasa Inggris: pro-c4) adalah sebuah glikoprotein yang berperan pada aktivasi . C4 teraktivasi saat terjadi ikatan antara antibodi dengan molekul target tertentu, dan teriris oleh menjadi dan . C4d merupakan degradasi dari C4. Setelah aktivasi dan degradasi molekul C4, gugus tio-ester akan tampak dan memungkinkan ikatan antara C4d dengan permukaan sel endotelial dan . C4d juga ditemukan pada intracytoplasmic vacuoles pada sel endotelial. Deteksi C4d dianggap merupakan pertanda tidak langsung dari respon antibodi. (in)
- Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system. It serves a number of critical functions in immunity, tolerance, and autoimmunity with the other numerous components. Furthermore, it is a crucial factor in connecting the recognition pathways of the overall system instigated by antibody-antigen (Ab-Ag) complexes to the other effector proteins of the innate immune response. For example, the severity of a dysfunctional complement system can lead to fatal diseases and infections. Complex variations of it can also lead to schizophrenia. The C4 protein was thought to derive from a simple two-locus allelic model, which however has been replaced by a much more sophisticated multimodular RCCX (en)
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| rdfs:label
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- Complement component 4 (en)
- Komponen komplemen 4 (in)
- Complementfactor C4 (nl)
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| owl:sameAs
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| prov:wasDerivedFrom
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| foaf:depiction
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| foaf:isPrimaryTopicOf
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| foaf:name
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- complement component 4A (Rodgers blood group) (en)
- complement component 4B(Chido blood group) (en)
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