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- In enzymology, a cholesterol 25-hydroxylase (EC 1.14.99.38) is an enzyme that catalyzes the chemical reaction cholesterol + AH2 + O2 25-hydroxycholesterol + A + H2O The 3 substrates of this enzyme are cholesterol, an electron acceptor AH2, and O2, whereas its 3 products are (25HC), the reduction product A, and H2O. This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is cholesterol, hydrogen-donor:oxygen oxidoreductase (25-hydroxylating). This enzyme is also called cholesterol 25-monooxygenase. Transcripts for this enzyme have been identified in macrophages from the testis. CH25H is an interferon-stimulated gene, and its primary product 25HC may have broad-spectrum antiviral activity, demonstrated in mice against HIV, ebola, Nipah virus, Rift Valley Fever virus, and SARS-CoV-2. Specifically, 25HC blocks membrane fusion between the cell and virus, and may "implicate membrane-modifying oxysterols as potential antiviral therapeutics.” Recently, upregulation of CH25H has been shown to play a role in effectively restricting infection of lung epithelial cells with SARS-Cov-2 through its enzymatic product, 25HC, which depletes accessible membrane cholesterol so that the virus is unable to achieve fusion with the cell membrane necessary for entry and infection. Interestingly, it has been proposed, based on experimental research in both mice and human cell culture, that 25HC is a potent senolytic. Further research needs to elaborate on this research and reveal its true significance to aging. (en)
- コレステロール-25-ヒドロキシラーゼ(taxadiene 5alpha-hydroxylase)は、次の化学反応を触媒する酸化還元酵素である。 コレステロール + 還元型受容体 + O2 25-ヒドロキシコレステロール + 受容体 + H2O この酵素の基質はコレステロール、還元型受容体とO2で、生成物は、受容体とH2Oである。 この酵素は酸化還元酵素に属し、基質に特異的に作用する。酸素は酸化剤として還元されると同時に基質に取り込まれる。組織名はcholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating)で、別名にcholesterol 25-monooxygenaseがある。 (ja)
- La colesterolo 25-idrossilasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: colesterolo + AH2 + O2 ⇄ 25-idrosscolesterolo + A + H2O A differenza della maggior parte delle sterolo idrossilasi, questo enzima non è un citocromo P-450. Utilizza invece i cofattori diferrici per catalizzare l'idrossilazione dei substrati idrofobici. Il cofattore diferrico può essere sia Fe-O-Fe che Fe-OH-Fe ed è legato all'enzima mediante interazioni con i di istidina e di acido glutammico. Nelle colture cellulari, questo enzima regola negativamente la sintesi del colesterolo ed il delle (proteine che legano il sito regolatorio dello sterolo, SREBPs). (it)
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- Cholesterol 25-hydroxylase (en)
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- コレステロール-25-ヒドロキシラーゼ(taxadiene 5alpha-hydroxylase)は、次の化学反応を触媒する酸化還元酵素である。 コレステロール + 還元型受容体 + O2 25-ヒドロキシコレステロール + 受容体 + H2O この酵素の基質はコレステロール、還元型受容体とO2で、生成物は、受容体とH2Oである。 この酵素は酸化還元酵素に属し、基質に特異的に作用する。酸素は酸化剤として還元されると同時に基質に取り込まれる。組織名はcholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating)で、別名にcholesterol 25-monooxygenaseがある。 (ja)
- La colesterolo 25-idrossilasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: colesterolo + AH2 + O2 ⇄ 25-idrosscolesterolo + A + H2O A differenza della maggior parte delle sterolo idrossilasi, questo enzima non è un citocromo P-450. Utilizza invece i cofattori diferrici per catalizzare l'idrossilazione dei substrati idrofobici. Il cofattore diferrico può essere sia Fe-O-Fe che Fe-OH-Fe ed è legato all'enzima mediante interazioni con i di istidina e di acido glutammico. Nelle colture cellulari, questo enzima regola negativamente la sintesi del colesterolo ed il delle (proteine che legano il sito regolatorio dello sterolo, SREBPs). (it)
- In enzymology, a cholesterol 25-hydroxylase (EC 1.14.99.38) is an enzyme that catalyzes the chemical reaction cholesterol + AH2 + O2 25-hydroxycholesterol + A + H2O The 3 substrates of this enzyme are cholesterol, an electron acceptor AH2, and O2, whereas its 3 products are (25HC), the reduction product A, and H2O. Transcripts for this enzyme have been identified in macrophages from the testis. (en)
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- Cholesterol 25-hydroxylase (en)
- Colesterolo 25-idrossilasi (it)
- コレステロール-25-ヒドロキシラーゼ (ja)
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- Cholesterol 25-hydroxylase (en)
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