IRF3

IRF3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3QU6, 1J2F, 1QWT, 1T2K, 1ZOQ, 2O61, 2O6G, 2PI0, 3A77, 5JEO, 5JEK, 5JER, 5JEM, 5JEL, 5JEJ
Dynodwyr
Cyfenwau	IRF3, entrez:3661, IIAE7, interferon regulatory factor 3
Dynodwyr allanol	OMIM: 603734 HomoloGene: 1208 GeneCards: IRF3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • protein homodimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001104 transcription coregulator activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • protein domain specific binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • sequence-specific DNA binding • identical protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • nucleoplasm • cnewyllyn cell • cytosol Prosesau biolegol • GO:0097285 apoptotic process • positive regulation of type I interferon-mediated signaling pathway • macrophage apoptotic process • GO:0009373 regulation of transcription, DNA-templated • response to bacterium • response to exogenous dsRNA • positive regulation of interferon-alpha production • MDA-5 signaling pathway • interferon-gamma-mediated signaling pathway • immune system process • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • cellular response to dsRNA • transcription, DNA-templated • cellular response to DNA damage stimulus • TRIF-dependent toll-like receptor signaling pathway • response to lipopolysaccharide • defense response to virus • type I interferon signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of type I interferon production • programmed necrotic cell death • GO:0022415 viral process • cellular response to lipopolysaccharide • positive regulation of type I interferon production • lipopolysaccharide-mediated signaling pathway • positive regulation of interferon-beta production • innate immune response • regulation of type I interferon production • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of defense response to virus by host • regulation of gene expression • regulation of inflammatory response • cellular response to exogenous dsRNA • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3661	n/a
Ensembl	ENSG00000126456	n/a
UniProt	Q14653	n/a
RefSeq (mRNA)	NM_001197122 NM_001197123 NM_001197124 NM_001197125 NM_001197126 NM_001197127 NM_001197128 NM_001571	n/a
RefSeq (protein)	NP_001184051 NP_001184052 NP_001184053 NP_001184054 NP_001184055 NP_001184056 NP_001184057 NP_001562 NP_001184053.1 NP_001184056.1 NP_001184057.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IRF3 yw IRF3 a elwir hefyd yn Interferon regulatory factor 3d ac Interferon regulatory factor 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19q13.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IRF3.

• IIAE7

Llyfryddiaeth

• "Knockdown of IRF3 inhibits extracellular matrix expression in keloid fibroblasts. ". Biomed Pharmacother. 2017. PMID 28192879.
• "Clarithromycin prevents human respiratory syncytial virus-induced airway epithelial responses by modulating activation of interferon regulatory factor-3. ". Pharmacol Res. 2016. PMID 27468646.
• "IRF-3 gene polymorphisms are associated with the susceptibility to and the survival in chronic lymphocytic leukemia and could also serve as an auxiliary index.". Leuk Lymphoma. 2017. PMID 27348780.
• "Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.". Proc Natl Acad Sci U S A. 2016. PMID 27302953.
• "1,8-Cineole potentiates IRF3-mediated antiviral response in human stem cells and in an ex vivo model of rhinosinusitis.". Clin Sci (Lond). 2016. PMID 27129189.