Dr. Jianmin Duan

Dr. Jianmin Duan

Greater Montreal Metropolitan Area
2K followers 500+ connections

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Bright Minds Biosciences

About

An experienced team leader with more than 20 years of track records in drug absorption…

Activity

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Experience

  • Bright Minds Biosciences

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    Australia

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    Laval, Qc, Canada

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    Montreal, Canada Area

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    BOEHRINGER INGELHEIM (CANADA) LTD., Laval, Quebec

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    BOEHRINGER INGELHEIM (CANADA) LTD., Laval, Quebec

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    Shandong, China

Education

Publications

  • Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: Discovery of a quinazolinone chemotype.

    Bioorg Med Chem Lett. 23(14):4132-40.

    Other authors
    See publication

  • Paper in peer reviewed jounals (2015)

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    56. Beaulieu PL, Bolger G, Deon D, Duplessis M, Fazal G, Gagnon A, Garneau A, LaPlantea S, Stammers T, Kukolj G, Duan J. Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor (part 2): impact of lipophilicity on promiscuity and in vivo toxicity. Bioorg Med Chem Lett, 25, 1140-1145, 2015.

    55. Beaulieu PL, Bolger G, Duplessis M, Gagnon A, Garneau M, Stammers T, Kukolj G, and Duan J. Aza follow-ups to BI 207524, a thumb pocket 1 HCV…

    56. Beaulieu PL, Bolger G, Deon D, Duplessis M, Fazal G, Gagnon A, Garneau A, LaPlantea S, Stammers T, Kukolj G, Duan J. Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor (part 2): impact of lipophilicity on promiscuity and in vivo toxicity. Bioorg Med Chem Lett, 25, 1140-1145, 2015.

    55. Beaulieu PL, Bolger G, Duplessis M, Gagnon A, Garneau M, Stammers T, Kukolj G, and Duan J. Aza follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor (part 1): mitigating the genotoxic liability of an aniline metabolite. Bioorg Med Chem Lett, 25, 1135-1139, 2015.

    54. Beaulieu PL, De Marte J, Garneau M, Luo L, Stammers T, Telang C, Wernic D, Kukolj G, Duan J. A prodrug strategy for the oral delivery of a poorly soluble HCV NS5B thumb pocket 1 polymerase inhibitor using self-emulsifying drug delivery systems (SEDDS). Bioorg Med Chem 25: 210-215, 2015.

    53. Beaulieu PL, Anderson PC, Bethell R, Bös M, Bousquet Y, Brochu C, Cordingley MG, Fazal G, Garneau M, Gillard JR, Kawai S, Marquis M, McKercher G, Poupart MA, Stammers T, Thavonekham B, Wernic D, Duan J, Kukolj G. Discovery of BI 207524, an Indole Diamide NS5B Thumb Pocket 1 Inhibitor with Improved Potency for the Potential Treatment of Chronic Hepatitis C Virus Infection. J Med Chem. 57:10130-10143, 2015.

  • PAPERS in peer reviewed journals (2012-2013):

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    40. Colombo, F., Poirier, H., Rioux, N., Montecillo, M. A., Duan, J., and Ribadeneira, M. Xenobiotica, In Press, 2013.
    39. Beaulieu, P.L., Coulombe, R., Gillard, J., Brochu, C., Duan, J., Garneau, M., Jolicoeur, E., Kuhn, P., Poupart, M. P., Rancourt, J., Stammers, T. A., Thavonekham, B., and Kukolj, G. Can. J. Chem. 91, 66–81, 2013.
    38. Sedykh, A., Fourches, D., Duan, J., Hucke, O., Garneau, M., Zhu, H., Bonneau, P., and Tropsha, A. Human Intestinal Transporter Database: QSAR Modeling…

    40. Colombo, F., Poirier, H., Rioux, N., Montecillo, M. A., Duan, J., and Ribadeneira, M. Xenobiotica, In Press, 2013.
    39. Beaulieu, P.L., Coulombe, R., Gillard, J., Brochu, C., Duan, J., Garneau, M., Jolicoeur, E., Kuhn, P., Poupart, M. P., Rancourt, J., Stammers, T. A., Thavonekham, B., and Kukolj, G. Can. J. Chem. 91, 66–81, 2013.
    38. Sedykh, A., Fourches, D., Duan, J., Hucke, O., Garneau, M., Zhu, H., Bonneau, P., and Tropsha, A. Human Intestinal Transporter Database: QSAR Modeling and Virtual Profiling of Drug Uptake, Efflux and Interactions. Pharm. Res. In Press, 2013.
    37. Rioux, N., Duan, J., Batonga, J., Colombo, F., Zouki, C., Ribadeneira, M., and Bethell, R. Xenobiotica, In press, 2013.
    36. Tremblay, M., Bonneau, P., Bousquet, Y., DeRoy, P., Duan, J., Duplessis, M., Gagnon, A., Garneau, M., Goudreau, N., Guse, I., Hucke, O., Kawai, S., Lemke, C., Mason, S. W., Simoneau, B., Surprenant, S., Titolo, S., Yoakim, C. Bioorg Med Chem Lett, in press, 2013.
    35. Duan, J., Bolger, G., Garneau, M., Amad, M., Batonga, J. l., Montpetit, H., Otis, F., Jutras, M., Lapeyre, N., Rhaume, M., Kukolj, G., White, P. W., Bethell, R. C., Cordingley, M. G. Antimicrob Agents Chemother 56, 5381-86, 2012.
    34. Beaulieu, P. L., Bös, M., Cordingley, M. G.., Chabot, C., Fazal, G., Garneau, M., Gillard, J. R., Jolicoeur, E., Laplante, S., McKercher, G., Poirier, M., Poupart, M. A., Tsantrizos, Y. S., Duan, J., Kukolj, G. Discovery of the First Thumb Pocket 1 NS5B Polymerase Inhibitor (BILB 1941) J Med Chem 55:7650-66, 2012.
    33. Duan, J., Yong, C. L., Garneau, M., Amad, M., Bolger, G., Marte, J.D., Montpetit, H., Otis, F., Jutras, M., Rhéaume, M., White, P. W., Llinàs-Brunet, M., Bethell, R. C., Cordingley, M. G. Cross-species absorption, metabolism, distribution and pharmacokinetics of BI 201335, a potent HCV genotype 1 NS3/4A protease inhibitor. Xenobiotica 42:164-72, 2012.
    32. Colombo, F., Armstrong, C., Duan, J., Rioux, N. Xenobiotica 42:157-63, 2012.

Languages

  • English

    Full professional proficiency

  • Chinese

    Native or bilingual proficiency

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