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Where such designations appear in this book, they have been printed with initial caps. McGraw-Hill Education eBooks are available at special quantity discounts to use as premiums and sales promotions or for
use in corporate training programs. To contact a representative, please visit the Contact Us page at [Link]. Notice Medicine is an ever-changing science. As new research and clinical experience
broaden our knowledge, changes in treatment and drug therapy are required. The authors and the publisher of this work have checked with sources believed to be reliable in their efforts to provide information
that is complete and generally in accord with the standards accepted at the time of publication.
However, in view of the possibility of human error or changes in medical sciences, neither the authors nor the publisher nor any other party who has been involved in the preparation or publication of this work
warrants that the information contained herein is in every respect accurate or complete, and they disclaim all responsibility for any errors or omissions or for the results obtained from use of the information
contained in this work. Readers are encouraged to confirm the information contained herein with other sources. For example and in particular, readers are advised to check the product information sheet included
in the package of each drug they plan to administer to be certain that the information contained in this work is accurate and that changes have not been made in the recommended dose or in the
contraindications for administration. This recommendation is of particular importance in connection with new or infrequently used drugs. TERMS OF USE This is a copyrighted work and McGraw-Hill Education
and its licensors reserve all rights in and to the work. Use of this work is subject to these terms. Except as permitted under the Copyright Act of 1976 and the right to store and retrieve one copy of the work, you
may not decompile, disassemble, reverse engineer, reproduce, modify, create derivative works based upon, transmit, distribute, disseminate, sell, publish or sublicense the work or any part of it without McGraw-
Hill Education’s prior consent. You may use the work for your own noncommercial and personal use; any other use of the work is strictly prohibited. Your right to use the work may be terminated if you fail to
comply with these terms. THE WORK IS PROVIDED “AS IS.” McGRAW-HILL EDUCATION AND ITS LICENSORS MAKE NO GUARANTEES OR WARRANTIES AS TO THE ACCURACY, ADEQUACY OR COMPLETENESS
OF OR RESULTS TO BE OBTAINED FROM USING THE WORK, INCLUDING ANY INFORMATION THAT CAN BE ACCESSED THROUGH THE WORK VIA HYPERLINK OR OTHERWISE, AND EXPRESSLY DISCLAIM
ANY WARRANTY, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE.
McGraw-Hill Education and its licensors do not warrant or guarantee that the functions contained in the work will meet your requirements or that its operation will be uninterrupted or error free. Neither
McGraw-Hill Education nor its licensors shall be liable to you or anyone else for any inaccuracy, error or omission, regardless of cause, in the work or for any damages resulting therefrom. McGraw-Hill Education
has no responsibility for the content of any information accessed through the work. Under no circumstances shall McGraw-Hill Education and/or its licensors be liable for any indirect, incidental, special, punitive,
consequential or similar damages that result from the use of or inability to use the work, even if any of them has been advised of the possibility of such damages. This limitation of liability shall apply to any claim
or cause whatsoever whether such claim or cause arises in contract, tort or otherwise. Contents Authors Preface 1. Introduction Gary D. Hammer, MD, PhD, & Stephen J. McPhee, MD 2. Genetic Disease Shane C.
Quinonez, MD, & Gregory Barsh, MD, PhD 3. Disorders of the Immune System Jeffrey L. Kishiyama, MD, Jennifer J. Chang, MD, & Suzanne M.
Donovan, MD, MPH 4. Infectious Diseases Christina T. Fiske, MD, MPH, & Karen C. Bloch, MD, MPH 5. Neoplasia Mark M. Moasser, MD, & Weiyun Z. Ai, PhD, MD 6.
Blood Disorders J. Ben Davoren, MD, PhD, & Gerald Hsu, MD, PhD 7. Nervous System Disorders Vikram G. Shakkottai, MD, PhD, & Catherine Lomen-Hoerth MD, PhD 8. Diseases of the Skin Laura B.
Pincus, MD, & Timothy H. McCalmont, MD 9. Pulmonary Disease Thomas H. Sisson, MD, Dru Claar, MD, Mark S.
Chesnutt, MD, & Thomas J. Prendergast, MD 10. Cardiovascular Disorders: Heart Disease Fred M. Kusumoto, MD, FACC 11. Cardiovascular Disorders: Vascular Disease Igor Mitrovic, MD 12. Disorders of the
Adrenal Medulla Lauren Fishbein, MD, PhD, & Tobias Else, MD 13. Gastrointestinal Disease Jason C. Mills, MD, PhD, AGAF, & Matthew A. Ciorba, MD 14.
 McGraw-Hill Education eBooks are available at special quantity discounts to use as premiums and sales promotions or for use in corporate training programs. To contact a representative, please visit the Contact
Us page at [Link]. Notice Medicine is an ever-changing science. As new research and clinical experience broaden our knowledge, changes in treatment and drug therapy are required. The
authors and the publisher of this work have checked with sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of
publication. However, in view of the possibility of human error or changes in medical sciences, neither the authors nor the publisher nor any other party who has been involved in the preparation or publication of
this work warrants that the information contained herein is in every respect accurate or complete, and they disclaim all responsibility for any errors or omissions or for the results obtained from use of the
information contained in this work. Readers are encouraged to confirm the information contained herein with other sources. For example and in particular, readers are advised to check the product information
sheet included in the package of each drug they plan to administer to be certain that the information contained in this work is accurate and that changes have not been made in the recommended dose or in the
contraindications for administration. This recommendation is of particular importance in connection with new or infrequently used drugs. TERMS OF USE This is a copyrighted work and McGraw-Hill Education
and its licensors reserve all rights in and to the work. Use of this work is subject to these terms. Except as permitted under the Copyright Act of 1976 and the right to store and retrieve one copy of the work, you
may not decompile, disassemble, reverse engineer, reproduce, modify, create derivative works based upon, transmit, distribute, disseminate, sell, publish or sublicense the work or any part of it without McGraw-
Hill Education’s prior consent. You may use the work for your own noncommercial and personal use; any other use of the work is strictly prohibited. Your right to use the work may be terminated if you fail to
comply with these terms. THE WORK IS PROVIDED “AS IS.” McGRAW-HILL EDUCATION AND ITS LICENSORS MAKE NO GUARANTEES OR WARRANTIES AS TO THE ACCURACY, ADEQUACY OR COMPLETENESS
OF OR RESULTS TO BE OBTAINED FROM USING THE WORK, INCLUDING ANY INFORMATION THAT CAN BE ACCESSED THROUGH THE WORK VIA HYPERLINK OR OTHERWISE, AND EXPRESSLY DISCLAIM
ANY WARRANTY, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. McGraw-Hill Education and its
licensors do not warrant or guarantee that the functions contained in the work will meet your requirements or that its operation will be uninterrupted or error free. Neither McGraw-Hill Education nor its
licensors shall be liable to you or anyone else for any inaccuracy, error or omission, regardless of cause, in the work or for any damages resulting therefrom. McGraw-Hill Education has no responsibility for the
content of any information accessed through the work. Under no circumstances shall McGraw-Hill Education and/or its licensors be liable for any indirect, incidental, special, punitive, consequential or similar
damages that result from the use of or inability to use the work, even if any of them has been advised of the possibility of such damages. This limitation of liability shall apply to any claim or cause whatsoever
whether such claim or cause arises in contract, tort or otherwise. Contents Authors Preface 1. Introduction Gary D. Hammer, MD, PhD, & Stephen J.

McGraw-Hill Education eBooks are available at special quantity discounts to use as premiums and sales promotions or for use in corporate training programs. To contact a representative, please visit the Contact
Us page at [Link]. Notice Medicine is an ever-changing science. As new research and clinical experience broaden our knowledge, changes in treatment and drug therapy are required. The
authors and the publisher of this work have checked with sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of
publication. However, in view of the possibility of human error or changes in medical sciences, neither the authors nor the publisher nor any other party who has been involved in the preparation or publication of
this work warrants that the information contained herein is in every respect accurate or complete, and they disclaim all responsibility for any errors or omissions or for the results obtained from use of the
information contained in this work. Readers are encouraged to confirm the information contained herein with other sources. For example and in particular, readers are advised to check the product information
sheet included in the package of each drug they plan to administer to be certain that the information contained in this work is accurate and that changes have not been made in the recommended dose or in the
contraindications for administration. This recommendation is of particular importance in connection with new or infrequently used drugs. TERMS OF USE This is a copyrighted work and McGraw-Hill Education
and its licensors reserve all rights in and to the work. Use of this work is subject to these terms. Except as permitted under the Copyright Act of 1976 and the right to store and retrieve one copy of the work, you
may not decompile, disassemble, reverse engineer, reproduce, modify, create derivative works based upon, transmit, distribute, disseminate, sell, publish or sublicense the work or any part of it without McGraw-
Hill Education’s prior consent.

ISBN: 978-1-26-002651-1 MHID: 1-26-002651-5 The material in this eBook also appears in the print version of this title: ISBN: 978-1-26-002650-4, MHID: 1-26-002650-7. eBook conversion by codeMantra Version
1.0 All trademarks are trademarks of their respective owners. Rather than put a trademark symbol after every occurrence of a trademarked name, we use names in an editorial fashion only, and to the benefit of
the trademark owner, with no intention of infringement of the trademark. Where such designations appear in this book, they have been printed with initial caps. McGraw-Hill Education eBooks are available at
special quantity discounts to use as premiums and sales promotions or for use in corporate training programs. To contact a representative, please visit the Contact Us page at [Link]. Notice
Medicine is an ever-changing science. As new research and clinical experience broaden our knowledge, changes in treatment and drug therapy are required. The authors and the publisher of this work have
checked with sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of publication. However, in view of the
possibility of human error or changes in medical sciences, neither the authors nor the publisher nor any other party who has been involved in the preparation or publication of this work warrants that the
information contained herein is in every respect accurate or complete, and they disclaim all responsibility for any errors or omissions or for the results obtained from use of the information contained in this work.
Readers are encouraged to confirm the information contained herein with other sources. For example and in particular, readers are advised to check the product information sheet included in the package of each
drug they plan to administer to be certain that the information contained in this work is accurate and that changes have not been made in the recommended dose or in the contraindications for administration.
This recommendation is of particular importance in connection with new or infrequently used drugs. TERMS OF USE This is a copyrighted work and McGraw-Hill Education and its licensors reserve all rights in
and to the work. Use of this work is subject to these terms. Except as permitted under the Copyright Act of 1976 and the right to store and retrieve one copy of the work, you may not decompile, disassemble,
 reverse engineer, reproduce, modify, create derivative works based upon, transmit, distribute, disseminate, sell, publish or sublicense the work or any part of it without McGraw-Hill Education’s prior consent.
You may use the work for your own noncommercial and personal use; any other use of the work is strictly prohibited. Your right to use the work may be terminated if you fail to comply with these terms. THE
WORK IS PROVIDED “AS IS.” McGRAW-HILL EDUCATION AND ITS LICENSORS MAKE NO GUARANTEES OR WARRANTIES AS TO THE ACCURACY, ADEQUACY OR COMPLETENESS OF OR RESULTS TO BE
OBTAINED FROM USING THE WORK, INCLUDING ANY INFORMATION THAT CAN BE ACCESSED THROUGH THE WORK VIA HYPERLINK OR OTHERWISE, AND EXPRESSLY DISCLAIM ANY WARRANTY,
EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. McGraw-Hill Education and its licensors do not warrant
or guarantee that the functions contained in the work will meet your requirements or that its operation will be uninterrupted or error free. Neither McGraw-Hill Education nor its licensors shall be liable to you or
anyone else for any inaccuracy, error or omission, regardless of cause, in the work or for any damages resulting therefrom. McGraw-Hill Education has no responsibility for the content of any information accessed
through the work. Under no circumstances shall McGraw-Hill Education and/or its licensors be liable for any indirect, incidental, special, punitive, consequential or similar damages that result from the use of or
inability to use the work, even if any of them has been advised of the possibility of such damages. This limitation of liability shall apply to any claim or cause whatsoever whether such claim or cause arises in
contract, tort or otherwise. Contents Authors Preface 1. Introduction Gary D.
Hammer, MD, PhD, & Stephen J. McPhee, MD 2.
Genetic Disease Shane C. Quinonez, MD, & Gregory Barsh, MD, PhD 3. Disorders of the Immune System Jeffrey L. Kishiyama, MD, Jennifer J. Chang, MD, & Suzanne M. Donovan, MD, MPH 4. Infectious Diseases
Christina T.
Fiske, MD, MPH, & Karen C. Bloch, MD, MPH 5. Neoplasia Mark M. Moasser, MD, & Weiyun Z. Ai, PhD, MD 6. Blood Disorders J. Ben Davoren, MD, PhD, & Gerald Hsu, MD, PhD 7. Nervous System Disorders
Vikram G. Shakkottai, MD, PhD, & Catherine Lomen-Hoerth MD, PhD 8. Diseases of the Skin Laura B. Pincus, MD, & Timothy H. McCalmont, MD 9.
Pulmonary Disease Thomas H. Sisson, MD, Dru Claar, MD, Mark S. Chesnutt, MD, & Thomas J. Prendergast, MD 10. Cardiovascular Disorders: Heart Disease Fred M. Kusumoto, MD, FACC 11. Cardiovascular
Disorders: Vascular Disease Igor Mitrovic, MD 12. Disorders of the Adrenal Medulla Lauren Fishbein, MD, PhD, & Tobias Else, MD 13. Gastrointestinal Disease Jason C. Mills, MD, PhD, AGAF, & Matthew A.
Ciorba, MD 14. Liver Disease Nizar A. Mukhtar, MD, & Mandana Khalili, MD, MAS 15. Disorders of the Exocrine Pancreas Timothy L. Frankel, MD, & Christopher J. Sonnenday, MD, MHS 16. Renal Disease Rachel
L.
Perlman, MD, & Michael Heung, MD, MS 17. Disorders of the Parathyroids & Calcium and Phosphorus Metabolism Dolores M. Shoback, MD 18. Disorders of the Endocrine Pancreas Janet L. Funk, MD 19.
Disorders of the Hypothalamus & Pituitary Gland Tobias Else, MD, & Gary D. Hammer, MD, PhD 20. Thyroid Disease Nazanene H. Esfandiari, MD, & Stephen J. McPhee, MD 21. Disorders of the Adrenal Cortex
Tobias Else, MD, & Gary D. Hammer, MD, PhD 22. Disorders of the Female Reproductive Tract Erika B. Johnston-MacAnanny, MD, Bansari G.
Patel, MD, & Robert N. Taylor, MD, PhD 23. Disorders of the Male Reproductive Tract Mikkel Fode, MD, PhD, Jens Sønksen, MD, PhD, & Dana A. Ohl, MD 24. Inf lammatory Rheumatic Diseases Allan C. Gelber,
MD, MPH, PhD, Stuart M. Levine, MD, FACP, & Erika Darrah, PhD 25. Case Study Answers Yeong S. Kwok, MD Index Authors Weiyun Z. Ai, PhD, MD Assistant Clinical Professor of Medicine Division of
Hematology/Oncology Helen Diller Family Comprehensive Cancer Center University of California, San Francisco School of Medicine San Francisco, California [email protected] Neoplasia Gregory Barsh, MD, PhD
Professor of Genetics and Pediatrics, Emeritus Stanford University School of Medicine Stanford, California [email protected] Genetic Disease Karen C. Bloch, MD, MPH Associate Professor of Medicine and Health
Policy Division of Infectious Diseases Department of Medicine Vanderbilt University School of Medicine Nashville, Tennessee [email protected] Infectious Diseases Jennifer J. Chang, MD, AAHIVS Fellow in HIV
Medicine David Geffen School of Medicine at the University of California, Los Angeles Los Angeles, California [email protected] Disorders of the Immune System Mark S.
Chesnutt, MD Professor of Medicine Pulmonary & Critical Care Medicine Department of Medicine and Dotter Department of Interventional Radiology Oregon Health & Science University Director, Critical Care VA
Portland Health Care System Portland, Oregon [email protected] Pulmonary Disease Matthew A. Ciorba, MD Associate Professor of Medicine Director, Inflammatory Bowel Disease Program Division of Biology &
Biomedical Sciences Division of Gastroenterology Washington University School of Medicine St. Louis, Missouri [email protected] Gastrointestinal Disease Dru Claar, MD House Officer, Internal Medicine
(Pulmonary) Pulmonary & Critical Care Medicine University of Michigan Hospitals Ann Arbor, Michigan [email protected] Pulmonary Disease Erika Darrah, PhD Assistant Professor of Medicine Division of
Rheumatology Department of Medicine Johns Hopkins University School of Medicine Baltimore, Maryland [email protected] Inflammatory Rheumatic Diseases J. Ben Davoren, MD, PhD Clinical Professor of
Medicine Associate Chief of Staff, Clinical Informatics San Francisco Veterans Affairs Medical Center Division of Hematology/Oncology Department of Medicine University of California, San Francisco School of
Medicine San Francisco, California [email protected] Blood Disorders Suzanne M. Donovan, MD, MPH Clinical Professor of Medicine Division of Infectious Diseases Department of Medicine David Geffen School of
Medicine at the University of California, Los Angeles [email protected] Disorders of the Immune System Tobias Else, MD Assistant Professor of Internal Medicine Division of Metabolism, Endocrinology & Diabetes
Department of Internal Medicine University of Michigan Medical School Ann Arbor, Michigan [email protected] Disorders of the Adrenal Medulla, Disorders of the Hypothalamus & Pituitary Gland, Disorders of
the Adrenal Cortex Nazanene H. Esfandiari, MD Associate Professor of Internal Medicine Division of Metabolism, Endocrinology & Diabetes Department of Internal Medicine University of Michigan Medical School
Ann Arbor, Michigan [email protected] Thyroid Disease Lauren Fishbein, MD, PhD Assistant Professor of Medicine Division of Endocrinology, Metabolism and Diabetes University of Colorado School of Medicine
Aurora, Colorado [email protected] Disorders of the Adrenal Medulla Christina T. Fiske, MD, MPH Assistant Professor of Medicine Division of Infectious Diseases Department of Medicine Vanderbilt University
School of Medicine Nashville, Tennessee [email protected] Infectious Diseases Mikkel Fode, MD, PhD Department of Urology Herlev & Gentofte Hospital University of Copenhagen Herlev, Denmark
[email protected] Disorders of the Male Reproductive Tract Timothy L. Frankel, MD Assistant Professor of Surgery Department of Surgery University of Michigan Medical School Ann Arbor, Michigan
[email protected] Disorders of the Exocrine Pancreas Janet L. Funk, MD Professor of Medicine Division of Endocrinology Want more? Advanced embedding details, examples, and help!