Other postoperative complications
Causes of postoperative hepatic dysfunction
• Increased bilirubin load
o Blood transfusion
o Haemolysis
o Haemolytic disorders
o Abnormalities of bilirubin metabolism
• Hepatocellular damage
o Pre-existing hepatic disease
o Viral hepatitis
o Sepsis
o Hypotension
o Hypoxaemia
o Drug-induce hepatitis
o Congestive cardiac failure
o General anaesthetic induced hepatic necrosis
• Extra-hepatic biliary obstruction
o Gallstones
o Ascending cholangitis
o Pancreatitis
o Common bile duct injury
Causes of postoperative renal failure
• Prerenal (hypoperfusion)
o Shock (hypovolaemia, cardiogenic, septic)
o Renal artery disease
• Renal (direct injury)
o Acute tubular necrosis (following prerenal, drugs, myoglobin)
o Glomerulonephritis
o Interstitial nephritis
• Postrenal (obstruction)
o Bladder outflow obstruction
o Single ureter (calculus, tumour)
o Both ureters (bladder malignancy)
Urinary tract infections
• 10% of patients admitted to hospital have a urinary catheter inserted
• Risk of catheter-related infection depends on:
o Age and sex of patient
o Duration of catheterisation
o Indication for catheterisation
• Bacterial colonisation of catheters is common
• If catheter required for more than 2 weeks 90% patients will develop bacteriuria
• Commonest organisms are enterobacter and enterococci
• Does not require treatment unless patient is systemically unwell
• Infection can be prevented by:
o Maintaining closed drainage system
o High infection control standards
o Preventing backflow from catheter bag
Postoperative confusion
• Occurs in 10% of postoperative patients
• Associated with increased morbidity and morality
• Leads to increased duration of hospitalisation
• Clinical features include
o Reduced level of consciousness
o Impaired thinking
o Impaired memory
o Perceptional abnormalities
o Disturbed emotion
o Psychomotor disturbance
Causes
• Hypoxia - respiratory disease, cardiac failure, arrhythmia
• Trauma - head injury
• Infection - intracranial, extracranial
• Neoplasia - primary and secondary cerebral tumours
• Vitamin deficiency - Thiamine (Wernicke’s encephalopathy), B12 deficiency
• Endocrine - hypothyroidism, hyperthyroidism, Addison’s disease
• Degenerative
• Vascular - CVA, TIAs
• Drugs
• Metabolic derangement