Gerhard Domagk

Gerhard Johannes Paul Domagk (German

pronunciation: [ˈɡeːɐ̯ haʁt ˈdoːmak] ; 30 October 1895 –
Gerhard Domagk
24 April 1964) was a German pathologist and
bacteriologist.

He is credited with the discovery of

sulfonamidochrysoidine (KL730) as an antibiotic for
which he received the 1939 Nobel Prize in Physiology
or Medicine. The drug became the first commercially
available antibiotic and marketed under the brand
name Prontosil.[3][4]

While working in the pathology department of the

University of Münster, Domagk was invited to join the
IG Farben branch at Elberfeld (later Wuppertal) in
1927. His duty was to test chemical compounds
prepared at the IG Farben laboratory for potential
drugs. A novel compound synthesised by Friedrich Born Gerhard Johannes Paul Domagk
Mietzsch and Joseph Klarer, a benzene derivative of 30 October 1895
azo dye attached with sulphonamide group as a side Lagow, Brandenburg, Kingdom of
chain was found to have antibacterial activity against Prussia, German Empire
human bacterium Streptococcus pyogenes. In 1935, (now Łagów, Świebodzin County,
Domagk's only daughter, Hildegarde, injured herself Lubusz Voivodeship, Poland)
and contracted a streptococcal infection. In a desperate Died 24 April 1964 (aged 68)
attempt to save his daughter's arm from amputation Burgberg, Baden-Württemberg,
and her life, Domagk used the new compound that West Germany
eventually cured the infection. Given the brand name
Nationality German
Prontosil, the new drug became the first antibiotic
commercially available for bacterial infections. Alma mater University of Kiel
Known for Discovery of sulfonamides such
Domagk was chosen to receive the 1939 Nobel Prize in as Prontosil as antibiotics[2]
Physiology or Medicine "for the discovery of the Spouse Gertrud Strube
antibacterial effects of prontosil,"[5] but the Nazi
Children One daughter and three sons
government prohibited him from receiving the award.
In 1947, after the fall of Nazi Germany, he was Awards Cameron Prize for Therapeutics
officially given the Nobel diploma and delivered the of the University of Edinburgh
Nobel lecture.[6] (1939)
Nobel Prize in Medicine (1939)
Paul Ehrlich and Ludwig
Biography Darmstaedter Prize (1956)
Domagk was born in Lagow, Brandenburg, German Fellow of the Royal Society
[1]
Empire (now Poland). His father Paul Richard (1959)
Domagk was a school teacher. He had an elder brother Scientific career
Erich, who died in childhood, and a younger sister,
Fields Bacteriology
Charlotte. When he was five, in 1900, his father was
transferred to Sommerfeld (now Lubsko, Poland). He
immediately entered the Bismarck School where he completed elementary education in 1910. Then, he
attended Herzog-Heinrich School in Liegnitz where he completed secondary education in 1914.[7]

Domagk entered the University of Kiel in 1914 to study medicine. As the First World War broke out, the
university was closed and he returned to Sommerfeld. He joined the German Grenadier Regimen 7 as a
volunteer along with 15 of his old school friends. In his first experience of war at Flanders in October
1914, he barely escaped death where 11 of his school friends were killed. He was transferred to eastern
front in Poland in December 1914, where he was shot on the head.[8] He was transported to Lichterfelde
near Berlin where he recovered from the injury. There he was given a training as medical orderly. In May
1915, he rejoined the eastern front as a medic. He recalled the horrors and suffering, especially of
infections, at the battlefields, saying "There horrible impressions kept pursuing me during my whole life,
and made me think how I could take measures against bacteria... I then swore, in case I would return to
my home alive, to work and work to make a small contribution to solve that problem."[9]

As the war ended in November 1918, Domagk resumed his medical course at Kiel. His doctoral thesis
titled Beeinflussung der Kreatininausscheidung durch Muskelarbeit[10] (Influence of Creatinine Excretion
in the Urine through Muscular Activity)[11] was supervised by Max Buerger and with that he earned his
degree in 1921.[12] Between 1922 and 1923, he worked as an assistant to Georg Hoppe-Seyler at Kiel.[11]

In 1923, he met Walter Gross, the Director of the Institute of Pathology at the University of Greifswald, at
the conference of German Society of Pathology in Leipzig. Gross was impressed with him and appointed
him a junior doctor at Greifswald.[12] He supported Domagk's research on phagocytosis, an immune
process discovered by Russian zoologist Elie Metchnikoff, so far as permitting excessive use of
electricity, constant photographic lights, and free roaming of experimental mice, all of which angered the
janitor. Domagk's thesis "Destroying infectious diseases through the reticuloendothelium and the
development of amyloid",[11] published in 1924 in Virchows Archiv für pathologische Anatomie und
Physiologie und für klinische Medizin (now Virchows Archiv)[13] was assessed as a worthy criterion for
promotion to a full professor. However, Gross was appointed to the University of Münster, and he invited
Domagk to join him as a lecturer at his proposed Department of Experimental Pathology.[14]

In 1925, he married Gertrude Strube, at the time an advisor to the German Chamber of Commerce in
Basel.[15] Later they had three sons and a daughter.[11]

At Münster, Domagk felt that the new department was not flourishing as he anticipated and was
underpaid. The IG Farben branch at Elberfeld (later Wuppertal) noticed him and offered him to lead their
institute of experimental pathology. When he informed of this opportunity to his university authority in
July 1927, and that he would stay if at least he was given a position of associate professor; he never
received a response. He took a sabbatical leave for two years without pay, and decided to accept IG
Farben's offer in 1929.[16] However, another source states that he joined the IG Farben in 1927.[11]
Domagk was appointed director of the Institute of Pathology and Bacteriology, started working at the IG
Farben laboratories at Wuppertal where he continued the studies of Josef Klarer and Fritz Mietzsch, based
on works by Paul Ehrlich, to use dyes, at that time a major product of the company, as antibiotics. He
changed his focus to tuberculosis and chemotherapy. He remained in that position until his retirement in
1961.[11]

Along with Albert Einstein, Domagk was one of the sponsors of the Peoples' World Convention (PWC),
also known as Peoples' World Constituent Assembly (PWCA), which took place in 1950-51 at Palais
Electoral, Geneva, Switzerland.[17][18]

Domagk died from a heart attack at his villa in the Black Forest village of Burgberg near Königsfeld,
Schwarzwald.[19]

Achievements

Prontosil
Domagk's responsibility at IG Farben was to test the new
compounds, chemical dyes, for antimicrobial activities. Werner
Schulemann, Friedrich Mietzsch, Hans Mauss and Joseph Klarer
were largely responsible for providing a continuous supply of
chemicals to be screened.[20] Since the end of the 19th century,
azo dyes, developed and used for colouring textile and other
materials, were found to have medicinal properties against
infections. For example, German biologist Paul Ehrlich used
methylene blue, a type of azo dye, to kill malarial parasites in
experimental animals, and cured two persons from malaria in
1891. Later, Ehrlich and his students found that some azo dyes
were effective against African sleeping sickness.[21] In 1913, P.
Eisenberg discovered that another azo dye, chrysoidine could kill
Tube of Prontosil tablets available in
bacteria and could be used as a disinfectant.[22][23] Following such Germany during 1935–1950
leads, IG Farben devoted to studying and chemically modifying
azo dyes for potential medicines.[21]

Development
In early 1930s, Mietzsch and Klarer synthesised a benzene derivative of azo dye, which was chemically
related to (an analogue of) chrysoidine.[24] The compound had an addition of sulphonamide group as a
side chain, thus becoming sulfamidochrysoidine. They suspected that a unique chemical component of
sulphonamide group in the new dye could be a possible drug candidate; as Mietzsch predicted: "[The
sulphonamide parts were] the right substituents in the right positions on the azo group."[20] The
compound was then labelled KL730 (KL for Klarer). IG Farben received a German patent for the new
compound in 1932.[25]
The exact date of synthesis is unknown.[24] An account that the IG Farben leader Heinrich Hörlein
suggested the use of sulfur group to azo dyes "some time in 1932"[26] may not be true, as IG Farben
received the patent of the first modified sulfamidochrysoidine on 7 November 1931.[27] The other related
compound received patent in December 1932.[25] Initial experiments in 1931 indicated poor antibacterial
effect against bacterial cultures. It was not known at the time that the active component of Prontosil was
the sulphonamide and not the azo group, as they expected. In addition, the sulphonamides by themselves
were not antibacterials, but only became active drug after metabolism inside the body. This is why the
first tests (in vitro) on bacterial cultures failed.[25]

Discovery of antibacterial activity

In early 1931,[27] Domagk immediately tested the compound in mice that were having bacterial infection,
and found that it was effective against Gram-positive bacteria.[28] He designated a code for the compound
D 4145 (D for Domagk).[26] He induced infection at the belly (peritonitis) of mice using clinical
specimens (isolates) of Streptococcus pyogenes. In the first experiment, he infected 26 mice by injecting
the bacteria, and he injected a single dose of Prontosil to 12 of the infected mice, while the rest 14 were
simply kept infected (as controls) without Prontosil treatment. All the Prontosil-injected mice survived,
meaning they were cured of the streptococcal infection,[20][29] whereas the untreated 14 mice all died by
the fourth day of experiment.[24] There were several more experimental tests, and a clinical trial in which
a boy was cured of streptococcal infection in 1933.[20] In February 1935, Domagk reported his
experiments in the journal Deutsche Medizinische Wochenschrift as "Ein Beitrag zur Chemotherapie der
bakteriellen Infektionen" ("A contribution to the chemotherapy of bacterial infections").[30][25]

At the time, there was no medical cure for streptococcal infection, and infected body parts had to be
surgically removed to prevent further spread of the infection.[31] This is still in practice when the
infection had caused severe tissue damage even after antibiotics are available.[32] In a notable incidence,
Domagk's six-year-old daughter, Hildegarde, injured herself with a stitching needle while making
Christmas decorations on 4 December 1935.[33][34] She fell on the stairs and stabbed her hand with the
needle, and the broken needle was stuck in her wrist. The needle was removed at a hospital. However, she
developed severe inflammation and fever from the next day. As Domagk recounted:

When the dressing was changed a few days later there was marked swelling of the hand, and
despite removal of all the stitches the fever continued to rise rapidly. In spite of numerous
incisions the inflammation phlegmon extended to the under-arm. A serious worsening of the
general condition and dizziness occurred, so that we were gravely worried about the child.
Since further surgical intervention was not possible, I asked permission of the treating
surgeon to use Prontosil, after I had established by culture that streptococci were the cause of
the illness.[33]

After making 14 incisions, the physician suggested that the only way to save Hildegarde was amputation
of the arm. However, Hildegarde recovered following the Prontosil treatment and her arm was saved.[25]

By 1935, Mietzsch and Klarer had prepared two forms of the compound, one is poorly soluble in water
while the other is highly soluble. The water-soluble compound was given a name Streptozon (specifically
Streptozon S, for the soluble sodium salt) after the bacterium with which it was originally experimented,
and the less water-soluble was called Prontosil (specifically Prontosil rubrum).[35] Prontosil was used as
the common name for both and the brand name of the drug after 1935. Domagk had used only the
Streptozon type.[36] He reported the development of the drug and his human application in article
"Chemotherapie der streptokokken-infektionen" ("Chemotherapy of streptococcus infection") in the
October issue of Klinische Wochenschrift (later Journal of Molecular Medicine).[37]

Confirmation
The first independent research was done by English physician Leonard Colebrook at the Queen
Charlotte's Maternity Hospital in London. Immediately after reading Domagk's paper, in 1935, Colebrook
repeated the experiments on mice using both soluble Streptozon and the less soluble form and found that
Streptozon was more effective but only in specific bacteria that caused puerperal fever.[38][39] However,
he found a serious side effect that the surviving mice developed severe kidney damages. This discouraged
him from human clinical trials, but he encountered one woman who was terminally ill from puerperal
fever. Without other options of treatment, he gave the Streptozon that cured the woman in a couple of
days. He tested the drug again on another woman with the same result, to which he remarked: "Almost at
once there was a surprising and most gratifying change."[29] With Méave Kenny, he treated 64 women
and reported the experiments and clinical trials in 1936.[36] The medical application was soon supported
by other clinical cases and Prontosil became the major antibiotic for the next decade.[25]

Sulfonamides had revolutionary antibacterial effectiveness for their time, surpassing phage therapy, but
were later replaced by penicillin, which showed both better effects and fewer side effects (sulfonamides
can cause kidney stones and changes in bone marrow). However, Domagk's work on sulfonamides
eventually led to the development of the antituberculosis drugs thiosemicarbazone and isoniazid, which
helped to curb the epidemic of tuberculosis which swept Europe after World War II. Although Prontosil
lost its popularity after the 1960s, its derivatives are continued to be used in several bacterial and viral
infections,[40] especially in the treatments of burns and urinary tract infections.[41]

Zephirol
In 1932, Domagk discovered the potential use of benzyldimethyldodecylammonium chloride as a
powerful antimicrobial agent. After a series of tests with different bacteria, he published in 1935 as a
disinfectant, naming it Zephirol.[42] Domagk explained how Zephirol applied to the skin, such as before
wearing gloves during surgery, could prevent infection.[43] It led to a successful marketing as a common
disinfectant. This was the discovery of quats,[44] chemicals that are later used in a variety of consumer
applications including as general antimicrobials (such as detergents and disinfectants), fabric softeners,
and hair conditioners.[45][46]

Cancer therapy
Since 1936, Domagk also focussed on cancer treatment.[47] In 1956, he reported the successful
development of an anticancer drug which he designated E-39 (E for ethylenimine quinones).[19] He
showed that the compound could destroy cancer cells such as Yoshida sarcoma, Ehrlich carcinoma and
Crocker sarcoma of mice and the Walker carcinoma of rats.[48][49] He was aware that precision drugs
would be required to target specific cancers, as he remarked:

In therapy we will have to be satisfied, for the present at least, with a certain equilibrium
between body cell and tumorous cell, even if the tumor cannot be completely eliminated. We
will be satisfied if we ca slow down it growth, in order to preserve the life of a patient longer
 and under bearable conditions.[50]

Although the drug did not find way into prescription treatment of cancer, it was continued to be
investigated[51][52] and several related compounds are still under experimental studies.[53][54][55]

Nobel Prize and issues

In 1939, Domagk was selected by the Nobel Foundation to receive the Nobel Prize in Physiology or
Medicine for the discovery of Prontosil as an antibiotic, the first commercially available drug effective
against bacterial infections. However, the Nazi Germany banned him from attending the award ceremony.
This was because Carl von Ossietzky, an outspoken anti-Nazi pacifist, had won the Nobel Peace Prize in
1935, which had angered the Nazi German government. Ossietzky was imprisoned and died in a
concentration camp. In 1937 Adolf Hitler made an official decree that prohibited German nationals from
accepting Nobel Prizes.[11][56]

On 27 October 1939, Domagk received a telegram from the rector of the Karolinska Institute in
Stockholm that he was to receive the Nobel Prize. He informed the rector of the University of Münster,
Walter Mevius, who immediately submitted a petition to the German authorities to allow Domagk to
receive the award. Domagk himself wrote to the NSDAP Office of the Führer, Hitler's headquarters, that
should he be allowed to receive the award, he would donate 100,000 Deutsche Marks for the war
cause.[11] On 17 November, he was arrested by the Gestapo who detained him for a week.[57][58][56] He
was released when he was verified that he supported the German National Socialism and was politically
loyal. However, he was informed to communicate with Karolinska Institute only through the government
departments such as the Ministry of Education or Foreign Office, and forced to decline the award.[11] It
was officially announced in Berlin that Domagk had "rather regretfully declined" the award.[19]

Two years after the end of World War II and the Nazi regime, the Nobel Foundation gave the Nobel
medallion and a diploma to Domagk in 1947. However, the monetary prize was not given as it was
already returned to the foundation.[28]

Awards and honours

Domagk was awarded the 1939 Nobel Prize in Physiology or Medicine. In the same year, Domagk was
also awarded the Cameron Prize for Therapeutics of the University of Edinburgh. In 1941 Domagk was
awarded the Medaglia Paterno (Rome) by the Kingdom of Italy and also the Von-Klebelsberg-Medal and
Prize by the Kingdom of Hungary. He became a member of the German Academy of Sciences
Leopoldina in 1942.

After the war, in 1947, Domagk was finally able to receive his Nobel Prize,[59] but not the monetary
portion of the prize due to the time that had elapsed. In 1951, he was one of seven Nobel Laureates who
attended the 1st Lindau Nobel Laureate Meeting.[60] He received the El Soleil del Perú in 1952, the Pour
le mérite für Wissenschaften und Künste in 1952, the Spanish Civil de Sanidad in 1953, the del
Lobertador from the Republic of Venezuela in 1957, the Medal of the Rising Sun 2nd Class from Japan in
1960, the Grand Cross with Star of the Order of Merit of the Federal Republic of Germany in 1955. In
1952, he was elected chairman of the German Society of Pathology.[11]
Domagk became a Foreign Member of the Royal Society in 1959; his short biography was published by
the Royal Society in 1964.[1][56]

Domagkpark, a public park, and Domagkstraße, a road, in Munich are named after Domagk. In Münster,
a research foundation called Krebsforschung Professor Dr. Gerhard Domagk (Cancer Research Professor
Dr. Gerhard Domagk) was established in 1961, and Gerhard-Domagk-Institut für Pathologie (Gerhard
Domagk Institute of Pathology) is created in the University of Münster.[11]

References
1. Colebrook, Leonard (1964). "Gerhard Domagk 1895–1964" ([Link]
m.1964.0003). Biographical Memoirs of Fellows of the Royal Society. 10: 38–50.
doi:10.1098/rsbm.1964.0003 ([Link]
2. Otten, H. (1986). "Domagk and the development of the sulphonamides" ([Link]
093%2Fjac%2F17.6.689). The Journal of Antimicrobial Chemotherapy. 17 (6): 689–696.
doi:10.1093/jac/17.6.689 ([Link] PMID 3525495 (http
s://[Link]/3525495).
3. Kyle, R. A.; Shampo, M. A. (1982). "Gerhard Domagk". JAMA: The Journal of the American
Medical Association. 247 (18): 2581. doi:10.1001/jama.247.18.2581 ([Link]
1%2Fjama.247.18.2581). PMID 7040718 ([Link]
4. "G. Domagk" ([Link] British Medical
Journal. 1 (5391): 1189–1191. 1964. doi:10.1136/bmj.1.5391.1189 ([Link]
6%2Fbmj.1.5391.1189). PMC 1813461 ([Link]
3461). PMID 14120818 ([Link]
5. Raju, T. N. (1999). "The Nobel chronicles. 1939: Gerhard Domagk (1895–1964)". Lancet.
353 (9153): 681. doi:10.1016/S0140-6736(05)75485-4 ([Link]
736%2805%2975485-4). PMID 10030374 ([Link]
S2CID 54410112 ([Link]
6. "The Nobel Prize in Physiology or Medicine 1939 Gerhard Domagk" ([Link]
bel_prizes/medicine/laureates/1939/). [Link]. Retrieved 2 July 2010.
7. Grundmann, Ekkehard (2004). Gerhard Domagk: The First Man to Triumph Over Infectious
Diseases ([Link] LIT Verlag Münster.
pp. 8–9. ISBN 978-3-8258-6164-3.
8. Grundmann, Ekkehard (2004). Ibid ([Link]
LIT Verlag Münster. pp. 12–13. ISBN 9783825861643.
9. Grundmann, Ekkehard (2004). Ibid ([Link]
LIT Verlag Münster. pp. 14–15. ISBN 9783825861643.
10. Domagk, Gerhard (1921). Beeinflussung der Kreatininausscheidung durch Muskelarbeit.
Universität Kiel. OCLC 793770685 ([Link]
11. Uhlendahl, Hendrik; Gross, Dominik (2020). "Victim or profiteer? Gerhard Domagk (1895–
1964) and his relation to National Socialism" ([Link]
Pathology, Research and Practice. 216 (6): 152944. doi:10.1016/[Link].2020.152944 (https://
[Link]/10.1016%[Link].2020.152944). ISSN 1618-0631 ([Link]
618-0631). PMID 32303387 ([Link]
S2CID 215810336 ([Link]
12. Grundmann, Ekkehard (2004). Ibid ([Link]
LIT Verlag Münster. pp. 16–18. ISBN 9783825861643.
13. Domagk, Gerhard (1924). "Untersuchungen über die Bedeutung des retikuloendothelialen
Systems für die Vernichtung von Infektionserregern und für die Entstehung des Amyloids" (h
ttp://[Link]/10.1007/BF01994397). Virchows Archiv für Pathologische Anatomie
und Physiologie und für Klinische Medizin (in German). 253 (3): 594–638.
doi:10.1007/BF01994397 ([Link] ISSN 0945-6317 (http
s://[Link]/issn/0945-6317). S2CID 10695542 ([Link]
CorpusID:10695542).
14. Grundmann, Ekkehard (2004). Ibid ([Link]
LIT Verlag Münster. pp. 21–22. ISBN 9783825861643.
15. Grundmann, Ekkehard (2004). Ibid ([Link]
LIT Verlag Münster. p. 18. ISBN 9783825861643.
16. Grundmann, Ekkehard (2004). Ibid ([Link]
LIT Verlag Münster. p. 26. ISBN 9783825861643.
17. Einstein, Albert; Nathan, Otto; Norden, Heinz (1968). Einstein on peace ([Link]
etails/einsteinonpeace00eins). Internet Archive. New York, Schocken Books. pp. 539, 670,
676.
18. "[Carta] 1950 oct. 12, Genève, [Suiza] [a] Gabriela Mistral, Santiago, Chile [manuscrito]
Gerry Kraus" ([Link]
BND: Archivo del Escritor. Retrieved 19 October 2023.
19. "Prof. Gerhard Domagk Dead; Won '39 Nobel Prize for Drug; Developed Prontosil, the First
Sulfonamide — Studied Cancer and TB" ([Link]
-[Link]). The New York Times.
26 April 1964. ISSN 0362-4331 ([Link] Retrieved
5 October 2022.
20. Wainwright, Mark; Kristiansen, Jette E. (2011). "On the 75th anniversary of Prontosil" (http
s://[Link]/retrieve/pii/S0143720810001853). Dyes and Pigments. 88 (3):
231–234. doi:10.1016/[Link].2010.08.012 ([Link]
2).
21. Wainwright, Mark (2008). "Dyes in the development of drugs and pharmaceuticals" ([Link]
[Link]/retrieve/pii/S0143720807000265). Dyes and Pigments. 76 (3): 582–
589. doi:10.1016/[Link].2007.01.015 ([Link]
22. Whitson, Theodore C. (1968). "Development of topical chemotherapy in the management of
burns" ([Link] The American
Journal of Surgery. 116 (1): 69–72. doi:10.1016/0002-9610(68)90420-0 ([Link]
016%2F0002-9610%2868%2990420-0). PMID 5652361 ([Link]
652361).
23. Durie, Beatrix (1938). "Sulphanamide" ([Link]
-5377.1938.tb46024.x). Medical Journal of Australia. 2 (27): 1103–1109. doi:10.5694/j.1326-
5377.1938.tb46024.x ([Link] ISSN 0025-
729X ([Link]
24. Kenny, Meave (1945). "Chemotherapy in Obstetrics and Gynaecology" ([Link]
[Link]/doi/10.1111/j.1471-0528.1945.tb07639.x). BJOG: An International Journal of
Obstetrics and Gynaecology. 52 (4): 372–388. doi:10.1111/j.1471-0528.1945.tb07639.x (htt
ps://[Link]/10.1111%2Fj.1471-0528.1945.tb07639.x). ISSN 1470-0328 ([Link]
[Link]/issn/1470-0328). S2CID 71576734 ([Link]
6734).
25. Chung, King-Thom (2016). "Azo dyes and human health: A review" ([Link]
[Link]/27635691). Journal of Environmental Science and Health. Part C, Environmental
Carcinogenesis & Ecotoxicology Reviews. 34 (4): 233–261. Bibcode:2016JESHC..34..233C
([Link]
doi:10.1080/10590501.2016.1236602 ([Link]
2). ISSN 1532-4095 ([Link] PMID 27635691 ([Link]
[Link]/27635691). S2CID 27970581 ([Link]
usID:27970581).
26. Bentley, Ronald (2009). "Different roads to discovery; Prontosil (hence sulfa drugs) and
penicillin (hence beta-lactams)" ([Link] Journal of
Industrial Microbiology & Biotechnology. 36 (6): 775–786. doi:10.1007/s10295-009-0553-8
([Link] ISSN 1476-5535 ([Link]
rg/issn/1476-5535). PMID 19283418 ([Link]
27. Brownlee, George (1949). "The Sulphonamides and Allied Compounds" ([Link]
com/articles/163662a0). Nature. 163 (4148): 662. Bibcode:1949Natur.163..662B ([Link]
[Link]/abs/1949Natur.163..662B). doi:10.1038/163662a0 ([Link]
8%2F163662a0). ISSN 1476-4687 ([Link]
S2CID 4120072 ([Link]
28. Rifkind, David (2005). "Prontosil and the sulfonamides". The Nobel Prize Winning
Discoveries in Infectious Diseases ([Link] London:
Elsevier/Academic. p. 39. ISBN 978-0-12-369353-2. OCLC 162572834 ([Link]
[Link]/oclc/162572834).
29. Wong, Sam (2017). "Sibling saviours of the maternity ward" ([Link]
science/article/pii/S0262407917302282). New Scientist. 233 (3111): 40–41.
Bibcode:2017NewSc.233...40W ([Link]
doi:10.1016/S0262-4079(17)30228-2 ([Link]
228-2). ISSN 0262-4079 ([Link]
30. Domagk, Gerhard (1935). "Ein Beitrag zur Chemotherapie der bakteriellen Infektionen" (htt
p://[Link]/DOI/DOI?10.1055/s-0028-1129486). Deutsche Medizinische
Wochenschrift (in German). 61 (7): 250–253. doi:10.1055/s-0028-1129486 ([Link]
0.1055%2Fs-0028-1129486). ISSN 0012-0472 ([Link]
S2CID 70515565 ([Link]
31. Estes, W. L. (1925). "Amputations in industrial surgery" ([Link]
ticles/PMC1400175). Annals of Surgery. 81 (1): 164–190. doi:10.1097/00000658-
192501010-00016 ([Link] ISSN 0003-
4932 ([Link] PMC 1400175 ([Link]
gov/pmc/articles/PMC1400175). PMID 17865165 ([Link]
5).
32. Sutherland, Mark E.; Meyer, Anthony A. (1994). "Necrotizing Soft-Tissue Infections" ([Link]
[Link]/retrieve/pii/S0039610916463310). Surgical Clinics of North America.
74 (3): 591–607. doi:10.1016/S0039-6109(16)46331-0 ([Link]
109%2816%2946331-0). PMID 8197532 ([Link]
33. Petri, William A. (4 April 2007). "The First Miracle Drugs: How the Sulfa Drugs Transformed
Medicine" ([Link]
JAMA. 297 (13). doi:10.1001/jama.297.13.1494 ([Link]
94). ISSN 0098-7484 ([Link]
34. Monosson, Emily (2015), "Discovery: Antibiotics and the Rise of the Superbug" ([Link]
[Link]/10.5822/978-1-61091-500-7_2), Unnatural Selection, Washington, DC: Island
Press/Center for Resource Economics, pp. 9–31, doi:10.5822/978-1-61091-500-7_2 (https://
[Link]/10.5822%2F978-1-61091-500-7_2), ISBN 978-1-59726-645-1, retrieved 4 March
2023
35. Braasch, William F. (1939). "Present status of chemotherapy for infections of the urinary
tract" ([Link] The American
Journal of Surgery. 45 (3): 472–478. doi:10.1016/S0002-9610(39)90471-X ([Link]
0.1016%2FS0002-9610%2839%2990471-X).
36. Colebrook, Leonard; Kenny, Méave (1936). "Treatment of Human Puerperal Infections, and
of Experimental Infections in Mice, with Prontosil" ([Link]
i/S014067360120734X). The Lancet. 227 (5884): 1279–1281. doi:10.1016/S0140-
6736(01)20734-X ([Link]
37. Domagk, Gerhard (1936). "Chemotherapie der Streptokokken-Infektionen" ([Link]
[Link]/10.1007/BF01780820). Klinische Wochenschrift (in German). 15 (44): 1585–1590.
doi:10.1007/BF01780820 ([Link] ISSN 0023-2173 (http
s://[Link]/issn/0023-2173). S2CID 5722987 ([Link]
orpusID:5722987).
38. Ellis, Harold (2011). "Leonard Colebrook and the treatment of puerperal sepsis" ([Link]
[Link]/21378618). British Journal of Hospital Medicine. 72 (2): 109.
doi:10.12968/hmed.2011.72.2.109 ([Link]
ISSN 1750-8460 ([Link] PMID 21378618 ([Link]
[Link]/21378618).
39. Dunn, P. M. (2008). "Dr Leonard Colebrook, FRS (1883-1967) and the chemotherapeutic
conquest of puerperal infection" ([Link] Archives of
Disease in Childhood. Fetal and Neonatal Edition. 93 (3): F246–248.
doi:10.1136/adc.2006.104448 ([Link] ISSN 1468-
2052 ([Link] PMID 18426926 ([Link]
[Link]/18426926). S2CID 19923455 ([Link]
5).
40. Apaydın, Sinem; Török, Marianna (15 August 2019). "Sulfonamide derivatives as multi-
target agents for complex diseases" ([Link]
Bioorganic & Medicinal Chemistry Letters. 29 (16): 2042–2050.
doi:10.1016/[Link].2019.06.041 ([Link]
ISSN 1464-3405 ([Link] PMID 31272793 ([Link]
[Link]/31272793). S2CID 195807205 ([Link]
sID:195807205).
41. Arivazhahan, Avinash (2021), Paul, Abialbon; Anandabaskar, Nishanthi; Mathaiyan,
Jayanthi; Raj, Gerard Marshall (eds.), "Sulfonamides, Quinolones, and Agents for Urinary
Tract Infections" ([Link] Introduction to
Basics of Pharmacology and Toxicology, Singapore: Springer Singapore, pp. 807–819,
doi:10.1007/978-981-33-6009-9_53 ([Link]
ISBN 978-981-336-008-2, S2CID 234297557 ([Link]
297557), retrieved 7 September 2022
42. Domagk, Gerhard (1935). "Eine neue Klasse von Desinfektionsmitteln" ([Link]
[Link]/DOI/DOI?10.1055/s-0028-1129654). Deutsche Medizinische Wochenschrift (in
German). 61 (21): 829–832. doi:10.1055/s-0028-1129654 ([Link]
8-1129654). ISSN 0012-0472 ([Link]
S2CID 71926126 ([Link]
43. Rahn, Otto; Van Eseltine, William P. (1947). "Quaternary ammonium compounds" ([Link]
[Link]/doi/10.1146/[Link].01.100147.001133). Annual Review of
Microbiology. 1 (1): 173–192. doi:10.1146/[Link].01.100147.001133 ([Link]
1146%[Link].01.100147.001133). ISSN 0066-4227 ([Link]
0066-4227).
44. Lim, XiaoZhi (2022). "Do we know enough about the safety of quat disinfectants?" ([Link]
[Link]/safety/consumer-safety/know-enough-safety-quat-disinfectants/98/i30).
[Link]. Retrieved 5 October 2022.
45. Bureš, Filip (2019). "Quaternary Ammonium Compounds: Simple in Structure, Complex in
Application" ([Link] Topics in Current
Chemistry. 377 (3): 14. doi:10.1007/s41061-019-0239-2 ([Link]
-019-0239-2). ISSN 2365-0869 ([Link]
PMID 31062103 ([Link] S2CID 146809199 ([Link]
[Link]/CorpusID:146809199).
46. Zubris, Deanna L.; Minbiole, Kevin P. C.; Wuest, William M. (2017). "Polymeric Quaternary
Ammonium Compounds: Versatile Antimicrobial Materials" ([Link]
27572084). Current Topics in Medicinal Chemistry. 17 (3): 305–318.
doi:10.2174/1568026616666160829155805 ([Link]
0829155805). ISSN 1873-4294 ([Link]
PMID 27572084 ([Link]
47. Domagk, Gerhard (1936). "Die synthetisch hergestellten carcinogenen Substanzen und ihre
Beziehungen zu physiologischen Produkten" ([Link]
3). Zeitschrift für Krebsforschung (in German). 44 (1): 160–186. doi:10.1007/BF01668053 (h
ttps://[Link]/10.1007%2FBF01668053). ISSN 0171-5216 ([Link]
171-5216). S2CID 30564489 ([Link]
48. Domagk, Gerhard (1956). "Histologische Veränderungen an experimentellen und
menschlichen Tumoren nach Darreichung von Zytostatika 1" ([Link]
DOI/DOI?10.1055/s-0028-1115792). Deutsche Medizinische Wochenschrift (in German). 81
(21): 801–806. doi:10.1055/s-0028-1115792 ([Link]
ISSN 0012-0472 ([Link] PMID 13330468 ([Link]
[Link]/13330468). S2CID 260087274 ([Link]
sID:260087274).
49. Domagk, Gerhard (1958). "Chemotherapy of cancer by ethylenimino quinones: its
foundations and problems" ([Link]
2681.x). Annals of the New York Academy of Sciences. 68 (3): 1197–1204.
Bibcode:1958NYASA..68.1197D ([Link]
D). doi:10.1111/j.1749-6632.1958.tb42681.x ([Link]
b42681.x). PMID 13627772 ([Link] S2CID 30047404
([Link]
50. Rotta, H. (1958). "Seventh Meeting of Nobel Prize Winners in Lindau" ([Link]
org/doi/10.1126/science.128.3329.905). Science. 128 (3329): 905–913.
doi:10.1126/science.128.3329.905 ([Link]
ISSN 0036-8075 ([Link]
51. Scholtissek, Christoph (1957). "Über die PH-Abhängigkeit bei der Einwirkung zweier
Äthyleniminchinone (Bayer E 39 und Bayer A 139) auf Nucleinsäuren" ([Link]
07/BF00524536). Zeitschrift für Krebsforschung (in German). 62 (2): 109–111.
doi:10.1007/BF00524536 ([Link] ISSN 1432-1335 (http
s://[Link]/issn/1432-1335). S2CID 44270951 ([Link]
CorpusID:44270951).
52. Gregl, Anton (1963). "Intrakavitäre Behandlung der Pleuritis carcinomatosa" ([Link]
[Link]/DOI/DOI?10.1055/s-0028-1112254). Deutsche Medizinische Wochenschrift
(in German). 88 (30): 1480–1484. doi:10.1055/s-0028-1112254 ([Link]
s-0028-1112254). ISSN 0012-0472 ([Link]
PMID 13950244 ([Link] S2CID 71993710 ([Link]
[Link]/CorpusID:71993710).
53. Madhuswapnaja, K. Jones; Yennam, Satyanarayana; Chavali, Murthy (2021), Shahid‐ul‐
Islam; Banday, Javid Ahmad (eds.), "Design, Synthesis, and Biological Evaluation of
Aziridynyl Quinone Derivatives" ([Link]
ch8), Chemistry of Biologically Potent Natural Products and Synthetic Compounds (1 ed.),
Wiley, pp. 205–250, doi:10.1002/9781119640929.ch8 ([Link]
40929.ch8), ISBN 978-1-119-64092-9, S2CID 236235376 ([Link]
orpusID:236235376), retrieved 5 October 2022
54. Kumar, P. Ravi; Yennam, Satyanarayana; Raghavulu, K.; Velatooru, Loka Reddy; Kotla,
Siva Reddy; Penugurti, Vasudevarao; Hota, Prasanta K; Behera, Manoranjan; Shree, A.
Jaya (2019). "Synthesis of Novel Diaziridinyl Quinone Isoxazole Hybrids and Evaluation of
Their Anti-Cancer Activity as Potential Tubulin-Targeting Agents" ([Link]
[Link]/DOI/DOI?10.1055/a-0810-7033). Drug Research. 69 (7): 406–414. doi:10.1055/a-0810-
7033 ([Link] ISSN 2194-9379 ([Link]
g/issn/2194-9379). PMID 30654398 ([Link]
S2CID 58630060 ([Link]
55. Swapnaja, K. Jones M.; Yennam, Satyanarayana; Chavali, Murthy; Poornachandra, Y.;
Kumar, C. Ganesh; Muthusamy, Krubakaran; Jayaraman, Venkatesh Babu; Arumugam,
Premkumar; Balasubramanian, Sridhar; Sriram, Kiran Kumar (2016). "Design, synthesis and
biological evaluation of diaziridinyl quinone isoxazole hybrids" ([Link]
gov/27089214). European Journal of Medicinal Chemistry. 117: 85–98.
doi:10.1016/[Link].2016.03.042 ([Link]
ISSN 1768-3254 ([Link] PMID 27089214 ([Link]
[Link]/27089214).
56. Schück, Henrik; Ragnar Sohlman; Anders Österling; Göran Liljestrand; Arne Westgren;
Manne Siegbahn; August Schou; Nils K. Ståhle (1950). "The Prize in Physiology and
Medicine: The Nobel Prizes in Wartime". In Nobel Foundation (ed.). Nobel: The Man and His
Prizes. Stockholm: Klara Civiltryckeri. pp. 167–179.
57. Thomas Hager, The Demon Under the Microscope (2006) ISBN 1-4000-8213-7 (cited in
"The Saga of a Sulfa Drug Pioneer" ([Link]
6667754) – NPR Weekend Edition 23 December 2006)
58. "[Link]" ([Link]
prizes/nobelprize_facts.html). Archived from the original ([Link]
obelprize_facts.html) on 2 February 2007.
59. Chorba, Terence (March 2018). "Peace, Liberty, Mycobacteria, and Tuberculosis Mortality"
([Link] Emerg Infect Dis. 24 (3): 611–
612. doi:10.3201/eid2403.AC2403 ([Link]
PMC 5823360 ([Link]
60. "1st Lindau Nobel Laureate Meeting – Laureates" ([Link]
g/laureates/meeting-1951). [Link]. Retrieved 9 January 2018.

External links
Gerhard Domagk ([Link] on [Link] including the
Nobel Lecture on 12 December 1947 Further Progress in Chemotherapy of Bacterial
Infections
Biography at Bayer ([Link]

Retrieved from "[Link]