E P I DE R MOSI L

Anti-aging (prevention) + regenerative (repair)

Stimulation of cells in the epidermis to provide better hydration and protection
Acts on cells in the dermis to provide a plumping effect

Alternative to surgery
Source of optimized hyaluronic acid

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epidermosil
Your expectations
Age and stress have visible effects on skin.
Over time, tissue becomes slack and skin cells wear out. Skin gets thinner and drier,
and loses density and elasticity.

Stresses, whether environmental or psychological, also affect skin structure and

metabolisms.

The aim is to compensate for the effects of stress and age by ensuring that the skin is well
hydrated, firm and has good elasticity, without needing surgery.

Young and zen skin Aged skin and/or stressed skin

EXSYMOL’s solution
Principle of action
The epidermis is the top-most layer of the skin and is the first cutaneous compartment exposed to stresses. It is thus a key target for any anti-
aging treatment.
-By stimulating the proliferation and action of keratinocytes. EPIDERMOSIL restores the thickness of the epidermis while significantly
increasing skin hydration, reducing TEWL and increasing hyaluronic acid content.
-The silicon in EPIDERMOSIL maintains collagen fibers, combats the effects of gravity and provides good skin elasticity.
-EPIDERMOSIL's silicon stimulates fibroblasts in the dermis which synthesizes more collagen for restructured, more compact
and firmer skin.

General characteristics
EPIDERMOSIL (INCI name: SILANETRIOL (and) HYALURONIC ACID) is a silanol specialized in anti-aging in which the organic silicon core
is combined with low-molecular weight hyaluronic acid (150-600kDa) to
potentialize it.
The organic silicon restructures the skin and balances the metabolisms
of all skin cells, providing an overall action on skin. Silicon also plays
the role of a vector and increases penetration, bioavailability and
hyaluronic
thus the action of the hyaluronic acid. acid
Potentialized low-molecular weight hyaluronic acid targets
keratinocytes in the basal lamina to maximize the anti-aging effect.

Si
hyaluronic hyaluronic

acid acid
 Cosmetic benefits

Consumer benefits
Combats deep and surface lines Skin protection
Lifting effect Fosters healing
Alternative to surgery Natural peeling
Hydration Combats psychological stress

Skin benefits
Stabilizing the epidermis Optimizing the dynamic link between fibroblasts and elastic fibers
Stimulating keratinocytes Stabilizing the structure of the dermal-epidermal junction
Synthesizing hyaluronic acid Improving biomechanical properties
Stabilizing the dermis Optimizing cellular communication
Stimulating fibroblasts Protection against the effects of cortisol
Collagen synthesis

Customer benefits - Novel concepts:

Active ingredient for different ranges - multifunctional active ingredient: anti-aging and dermocosmetics
Skin care responding to the skin's needs
Exogenic (provides HA) and endogenic (stimulating HA production) hydration
Combats urban stress (pollution, stressful lifestyle)
Skin is prepared to optimize the effectiveness of another active ingredient
Protection against the effects of stress
Potentialized hyaluronic acid
Action on progenitor cells
Easy formulation (stable, colorless, odorless, etc.)
epidermosil
The epidermis specialist

EPIDERMOSIL is capable of stimulating keratinocyte proliferation. HA

By enhancing low molecular weight hyaluronic acid penetration and
CD44
bioavailability, a higher amount of HA is capable of binding its receptor CD44
at the surface of keratinocytes hence triggering three reactions: 2 3

Keratinocyte
1 Keratinocyte proliferation that will lead to epidermis thickening
2 Keratinocyte production of HA 1
3 Overexpression of hyaluronic acid receptor CD44
Proliferation

1 Keratinocyte proliferation that will lead to epidermis thickening

HRE were treated with silicium alone, with

175
HA alone or with EPIDERMOSIL at the same +63%

Ki67 positive cells (% of control)

150

concentration and the number of proliferating 125

+28%
keratinocytes (Ki67 positive cells marked in +20%
Control MTS 5% 100

green) was assessed. Both silicium and HA alone 75

stimulate keratinocyte proliferation. EPIDERMOSIL 50

has a stronger cytostimulating effect than both HA 25

and silicium pooled together, hence showing the 0

Control MTS (5%) HA (5%) Epidermosil
synergy created by this compound. (5%)

HA 5% EPIDERMOSIL 5%

2 Keratinocyte production of HA

500
HA production (% of control)

Human skin explants were treated with 400

+300%
EPIDERMOSIL (5%) for 9 days. By the end of the 300
Control
treatment, the amount of HA (stained in blue)
200
present in the skin was improved, suggesting a strong
HA-induced HA production by the keratinocytes 100

from the epidermis. 0

Control Epidermosil

EPIDERMOSIL

3 Overexpression of hyaluronic acid receptor CD44

150
Human reconstructed epidermis (HRE) were
125 +37%
CD44 expression (% of control)

topically treated with silicium alone (MTS), HA alone +26%

100
or EPIDERMOSIL at the same concentration. NS

Control MTS 5% 75

A stronger overexpression of CD44 (marked in 50

green) was observed in the EPIDERMOSIL treated 25

HRE. 0
Control MTS (5%) HA (5%) Epidermosil

AH 5% (5%)

HA 5% EPIDERMOSIL 5%

The benefits provided by EPIDERMOSIL are higher that the combination of organic silicium and HA together. This synergy is
responsible for a strong cytostimulation of the keratinocytes, leading to a thickening of the epidermis for an improved protection and
hydration of the skin.
 epidermosil
The epidermis specialist
EPIDERMOSIL negates the effects of psychological stress on skin by protecting filopodia and preserving the
hyalurosome
Psychological stress is mediated by cortisol. This hormone will have a dual effect on skin via its specific effect on keratinocytes’
filopodia. Filopodia are cell overgrowth that are responsible for ensuring keratinocyte mobility and response to hyaluronic acid via the
hyalurosome. They are therefore key for the cytostimulation, healing and hydration processes.

CD44

Hyalurosome HAS3
EGF-3
Filopode EGF
HA
Filaments d’actin

Kératinocyte Control Cortisol + EPIDERMOSIL

While cortisol is responsible for dramatically decreasing the filopodia’s length, the treatment with EPIDERMOSIL is capable of strongly
increasing their length. EPIDERMOSIL is therefore capable of opposing the noxious effects of psychological stress on skin.

EPIDERMOSIL improves the wound healing process EPIDERMOSIL

improves skin protection and hydration
Wound healing and cortisol EPIDERMOSIL ensures skin hydration
Filopodia ensure the cell mobility which is a key mechanism in In order to assess EPIDERMOSIL’s ability to protect the skin
the wound healing and regeneration processes from dehydration and to help it recovering from a severe
By decreasing filopodia length, psychological stress leads to a stress, we exposed human skin explants to acetone.
decrease in the skin healing process. Aquaporin-3 is a protein responsible for the creation of
transmembrane pores which allow water transport across
cell membranes. As a result, aquaporin-3 ensures optimal
moisturization in the epidermis. Because of acetone exposure
aquaporin-3 (in green) is strongly inhibited and a treatment
with EPIDERMOSIL (5%) completely restores its optimal
0h Control expression. Similar results were observed for other key
proteins in the hydration process such as filaggrin and loricrin.

Cortisol + EPIDERMOSIL
Control + Acetone + EPIDERMOSIL
Cortisol causes dehydration and a loss of protection
EPIDERMOSIL is capable of opposing the effects of cortisol on
Filopodia are home to the hyalurosome where the binding
keratinocytes and is therefore able to restore their mobility and
of hyaluronic acid to its receptor CD44 occurs. By affecting
their proliferation for an optimal skin healing and regeneration.
filopodia, psychological stress thus leads to a thinner
Wound healing and aging
epidermis.
The healing process depends on both keratinocyte proliferation 100

and migration. Treatment of keratinocytes in a scratch test 80

Epidermis thickness

assay showed that the “wound” was closed faster and more
(% of control)

60

efficiently in the presence of EPIDERMOSIL. This clearly shows 40

that EPIDERMOSIL is capable of improving the healing process 20

by stimulating keratinocyte proliferation rate and mobility. 0

Control Cortisol EPIDERMOSIL
Control
Control EGF (25 ng/ml) EPIDERMOSIL (2.5%) EPIDERMOSIL (5%)

Cortisol + EPIDERMOSIL (2.5%)

EPIDERMOSIL is capable of protecting the hyalurosome from

the effects of cortisol. It therefore allows an optimal response
*EGF = Epidermis Growth factor (positive control) to hyaluronic acid that will lead to a thicker epidermis.
EPIDERMOSIL
Global benefits for anti-aging effect

EPIDERMOSIL specifically targets TA cells for enhanced proliferation

Keratinocyte stem cells (KSC) are quiescent cells that A. B.

rarely proliferate. When they do, they usually produce 125 180
+14%
another KSC and a transient amplifying cell (TA). NS
160 TA
100
TA + Epidermosil (0.1%)

(% of control)
KSC have a limited proliferation quota and thus should 140

Cell number (106 cells)

not be stimulated as they form the pool of proliferating 75
120

cell viability
%of control
100
cells. On the other hand, TA are responsible for

Cell viability
80
proliferating and are therefore an optimal target for any 50
60

skin treatment. 40
25

20

EPIDERMOSIL specifically targets TA cells and is capable 0

KSC TA
0
Time (plating number)
of improving their proliferation rate (A), and of increasing
their ability to proliferate for a longer period of time (B).

EPIDERMOSIL: synergetic effect for global skin benefits

Epidermis thickening (HA)
I

I
80
80

As a result of all the benefits provided by EPIDERMOSIL,

Epidermis thickness
Epidermis thickness ( μm)
60
60

(mm)(µm)
a treatment with this compound provides the skin with +39%
40
40

global improvements at all levels:

20
20

00
Control EPIDERMOSIL
- The epidermis is thicker and of a better quality 9 days EPIDERMOSIL
(5%)
for higher skin protection and a reduced trans Collagen Booster (Si)
1500
1500

epidermal water loss (TEWL).

Collagen density (% of control)

13x
Collagen density
(% of control)

1000
1000

- The dermis is denser for a more resistant, flexible 500

500

and elastic skin.

0
0
Control EPIDERMOSIL

Clinical test with EPIDERMOSIL

I
I

Realized under dermatological control, a clinical trial was performed on 35 women aged 40 to 59.
The volunteers received a treatment with EPIDERMOSIL (5%) applied twice a day on the face for 28 days.

Before After Before

General appearance +36.4%

Radiance +7.4%

Texture +36.4%

Wrinkles +13.3%
After

Elasticity +14.3%

Moisturization +37.5%

0 10 20 30 40
Average improvement (%)

The plumping benefits from both organic silicium and the low molecular weight hyaluronic acid led to a decrease of
wrinkle depth and to an improvement of skin elasticity together with a high hydration level.
100 % of volunteers had a general skin improvement with a healthier, younger looking skin.
 Technical characteristics

Analytical composition
INCI name Methylsilanetriol 0.3 %
(including silicium 0.09 %)
Silanetriol (and) hyaluronic acid
Low molecular weight hyaluronic acid 0.35 %
Water (sq) 100 %

Preservatives Physico-chemical characteristics

Different preservative systems are available Limpid to slightly opalescent, colorless to yellowish liquid
in order to fit with your requirements. pH ≈ 5.5
Please contact us for additional details Density at 20°C ≈ 1.0
about the available versions. Miscible with water, opalescent in alcohols
Not miscible in oils.

Formulation Tolerance and toxicity studies

EPIDERMOSIL is perfectly tolerated.
Advised doses: 3 to 6%.
Tolerance and toxicity studies were performed using both
Incompatibilities:
in vitro (cell culture and reconstructed epidermis)
No particular formulation restriction.
and in vivo (human volunteers) methods.

Availabilities
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is available in 5 and 30 kg drums.

 EXSYMOL S.A.M.
4 avenue Albert II – MC 98000 MONACO
Tél: +377 92 05 66 77
exsymol@[Link]
[Link]
P8_1408GB1903I

GMP
CERTIFIED