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Drug Name Mechanism of Action Indication Side Effects Nursing Reponsibilities Generic Name

This document summarizes information about the drugs Sitagliptin and Linagliptin used to treat Type 2 Diabetes. Sitagliptin works by inhibiting the DPP-IV enzyme, prolonging the effects of incretin hormones and regulating blood glucose. Its common side effects include headache, nasopharyngitis, and gastrointestinal issues. Nurses are responsible for monitoring patients for side effects and ensuring proper medication administration. Linagliptin also works by inhibiting DPP-4 to increase incretin hormone levels, regulating glucose levels. It is used as an adjunct treatment with diet and exercise or other antidiabetic drugs. Nurses educate patients on safety, side effects like hypoglycemia,

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647 views4 pages

Drug Name Mechanism of Action Indication Side Effects Nursing Reponsibilities Generic Name

This document summarizes information about the drugs Sitagliptin and Linagliptin used to treat Type 2 Diabetes. Sitagliptin works by inhibiting the DPP-IV enzyme, prolonging the effects of incretin hormones and regulating blood glucose. Its common side effects include headache, nasopharyngitis, and gastrointestinal issues. Nurses are responsible for monitoring patients for side effects and ensuring proper medication administration. Linagliptin also works by inhibiting DPP-4 to increase incretin hormone levels, regulating glucose levels. It is used as an adjunct treatment with diet and exercise or other antidiabetic drugs. Nurses educate patients on safety, side effects like hypoglycemia,

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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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DRUG NAME MECHANISM OF INDICATION SIDE EFFECTS NURSING

ACTION REPONSIBILITIES

GENERIC NAME: Sitagliptin inhibits Type 2 Diabetes CNS: headache  Monitor renal
Sitagliptin dipeptidyl peptidase IV Mellitus EENT: nasopharyngitis
(DPP-IV) enzyme GI: abdominal pain, function periodically.
BRAND NAME: resulting in prolonged nausea, diarrhea  Measure patient’s
Januvia, Xelevia active incretin levels. weight and body
Incretin hormones,
mass index
CLASSIFICATION: including glucagon-like
Antidiabetic peptide 1 (GLP-1) and periodically during
glucose-dependent therapy.
DOSAGE: insulinotropic  Monitor blood
50 mg polypeptide (GIP),
regulate glucose glucose and
ROUTES: homeostasis by hemoglobin A1c
CONTRAINDICATION ADVERSE EFFECTS
Oral increasing insulin levels periodically
synthesis and release
FREQUENCY: from pancreatic β-cells Patients with Type 1 Metabolic: during therapy.
OD and decreasing diabetes or hypoglycemia  Monitor patient for
glucagon secretion from ketoacidosis signs and symptoms
TIMING: pancreatic α-cells. Potentially
Contraindicated in Fatal: Acute of hypersensitivity
8 AM Reduced glucagon
secretion leads in patients with history of pancreatitis, serious reactions and
decreased hepatic hypersensitivity to hypersensitivity immediately stop
glucose production. sitagliptin. reactions 
drug and institute
Under normal
physiologic Respiratory: upper emergency
circumstances, incretin respiratory tract measures if such
hormones are released infection
reactions occur
by the intestine
throughout the day and  Check for diabetes
levels are increased in signs and symptoms

MOA Source: https://www.mims.com/philippines/drug/info/sitagliptin?


mtype=generic
response to a meal; and disease
incretin hormones are
rapidly inactivated by progression routinely
the DPP-IV enzyme. during therapy

 Instruct patient to
take drug with or
without food.

 Teach patient about


signs and symptoms
of hypoglycemia
(such as blurred
vision, confusion,
tremor, sweating,
excessive hunger,
drowsiness, and fast
heart rate).
DRUG NAME MECHANISM OF ACTION INDICATION SIDE EFFECTS NURSING REPONSIBILITIES
GENERIC NAME:  Linagliptin inhibits
Linagliptin dipeptidyl peptidase-4 Adjunct to diet and CNS: headache  Monitor patient for
(DPP-4), an enzyme exercise to improve EENT: nasopharyngitis signs and symptoms
which is involved in the glycemic control in of hypoglycemia.
BRAND NAME: inactivation of the adults with type 2  Monitor blood
Trajenta incretin hormones GLP- diabetes as glucose levels
1 (glucagon-like monotherapy or periodically
CLASSIFICATION: peptide-1) and GIP combination therapy  Inform patient of
Antidiabetics (glucose-dependent with insulin retagogue potential risks and
insulinotropic (such as sulfonylurea). benefits of linagliptin
DOSAGE: polypeptide). Both and of alternative
5 mg/ 1 tab incretin hormones are modes of therapy.
involved in the  Instruct patient to
ROUTES: physiological regulation tale drug only and
CONTRAINDICATION ADVERSE EFFECTS
Oral of glucose homeostasis. prescribed
Inhibition of DPP-4  Teach patient to
FREQUENCY: leads to increased and Contraindicated in GI: diarrhea recognize and
O.D. prolonged active patients hypersensitive Metabolic: manage
incretin levels. to the drug hypoglycemia hypoglycemia and
TIMING: Musculoskeletal: hyperglycemia.
8 am Drug not use for arthralgia, myalgia
 Advise patient to
patients with type 1 Respiratory: URI
notify health care
diabetes or for
provider promptly
treatment of
during period of
ketoacidosis
stress.

MOA Source: https://www.mims.com/philippines/drug/info/linagliptin?


mtype=generic

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