Science Magazine

This week’s new issue of #ScienceSignaling has arrived! https://scim.ag/45HomG3

A series of high-energy particle collision experiments tests a decades-old hypothesis about the proton’s baryon number—a conserved quantum property that distinguishes matter from antimatter. The findings in Science offer support for the idea that baryons are likely carried by a Y-shaped gluonic structure known as a baryon junction, and offer insights into the origin of the proton’s identity and how matter is organized throughout the Universe. 📄: https://scim.ag/4gb7VXq #SciencePerspective: https://scim.ag/3UCr7WM

"I have learned that stepping into these uncertain situations has helped me grow and uncover hidden passions that I never would have discovered otherwise." This week's Working Life. https://scim.ag/4xSU532

Congratulations to Ravi Rungta and the team on publishing this impressive work in Science Magazine! As someone who recently transitioned from mouse research to human neuroimaging (fMRI, fNIRS, EEG) for postdoc, this paper felt especially relevant to my journey. Having spent my PhD looking at micro-scale circuit dynamics in rodents, those insights are very helpful for interpreting macro-scale human signals today. Bridging these two scales has been a very interesting experience and has given me a sense of both the power and the boundaries of non-invasive human imaging (though I am keeping the door open for rodent work in the future!). Please check out the paper: https://lnkd.in/gxkq-PDe and our Perspective piece: https://lnkd.in/gAKF6rwi

I wrote a review of Jill Lepore's #book, The Rise and Fall of the Artificial State, for Science Magazine. Curiously enough, both our books have ended up long listed for the FT Business Book Prize of the Year. #BBYA26 https://lnkd.in/eR5FBtC5

I’m excited to share that our paper, “Ptpn2 limits plasma cell fate and antiviral immunity by integrating B cell receptor and IFN-γ signals in B cells,” is now published in Science Advances! Our study demonstrates that Ptpn2 acts as an important regulator of B cell fate by limiting both B cell receptor and cytokine signaling. We found that Ptpn2 integrates signals from the B cell receptor and IFN-γ to regulate B cell differentiation and antibody responses. In its absence, B cells preferentially differentiate into antibody-secreting plasma cells cells and produce stronger antiviral antibody responses. Together, these findings identify Ptpn2 as a potential target for enhancing antiviral humoral immunity and improving vaccine-induced antibody responses. A special thank you to my co-authors and collaborators, Alexandre Poirier, PhD, Isabelle Aubry, Philippe Aumont, Aanya Bhagrath, Noriko Uetani, Bianca Colalillo, Chenyue Wu, Benoit Charbonneau, Stéphanie Bussières-Marmen, PhD, Belma M. Abidin, Javier M. Di Noia, Judith N. Mandl, Silvia M. Vidal, Jorg H. Fritz and of course my supervisor, Michel L Tremblay for his guidance and support. 🔗Here is the link to the full article if you would like to know more: https://lnkd.in/dntpfzc7

Can AI push science forward or only fill in the gaps? Science Editor-in-Chief Holden Thorp discusses with James Evans, a computational social scientist and professor of sociology at the University of Chicago. Learn more: https://scim.ag/4bXUuJf

Like anthropologist Barbara King, I would no sooner eat an octopus than my pet, but I loved learning about the challenges—some technical, some ethical— faced by would-be octopus aquaculturists while editing King's review of "Life on the Octopus Farm" for Science Magazine. Could farmed octopus really be a new source of sustainable protein for the masses or is it more likely that it would just become one more option for elite diners? https://lnkd.in/euJRP6cw

In the DNA of bison, scientists find clues to the animals’ past—and keys to safeguarding their future. Learn more: https://scim.ag/45XBqXY

Nearly 2 decades ago, DNA inside a pinkie finger bone found in a Siberian cave revealed the existence of what are now known as the Denisovans, an extinct close evolutionary cousin of Neanderthals and our own species. But in the years since, only a skull and a few more teeth and bone fragments have been definitively linked to these mysterious humans, making it difficult to determine what the rest of their bodies looked like. Now, researchers report that a pair of ancient leg bones, a femur and partial tibia, scooped up from the bottom of the Strait of Taiwan, may hold valuable clues. Learn more: https://scim.ag/4gblMhB