Flagship Pioneering

To test whether Synteins™ behave differently than natural proteins, the Abiologics team compared sequence-matched L-proteins and Synteins™ in protease-rich environments where proteins are rapidly degraded. L-proteins were degraded within hours in rodent serum and became undetectable after just two minutes in simulated intestinal fluid. Synteins™, by contrast, remained intact for at least seven days in serum and five days in intestinal fluid. These findings demonstrate a fundamental property of D-proteins: intrinsic resistance to protease degradation. That durability could expand the range of therapeutic applications and delivery routes that may be possible, including oral administration. Read more at the Labs Report: https://bit.ly/4vrLYsy

"Can we take these beneficial forms of RNA and turn them into a tool that we can use?” Ryan Rapp joins Justine Levin-Allerhand to discuss the origins of Terrana Biosciences, the research that shaped its early direction, and what's possible when we learn from nature. Watch the full conversation on The Labs Report: https://lnkd.in/g_D4M6vY

We gathered leaders across AI and life sciences to explore polyintelligence — the synthesis of human, artificial, and nature's intelligence to unlock new forms of problem solving. Flagship Senior Partner Matthew Davis shares why AI's rapid acceleration should inspire us not only to move faster, but also to pursue more ambitious outcomes for science, society, and human health. More on polyintelligence: https://lnkd.in/gP3sWQHs

Forbes has named Flagship Chief Operating Officer and General Partner Yvonne Hao to their 2026 50 Over 50 list, recognizing her leadership in investment, building and scaling businesses, and advancing economic growth across the private and public sectors. The sixth annual 50 Over 50 list, produced in partnership with Mika Brzezinski's Know Your Value, recognizes 200 women actively leading organizations, building businesses, advancing scientific discovery, shaping policy, and driving social change. Age and experience, as Forbes puts it, "supercharge impact." 

We recently shared a deep dive on crop protection on our Substack, The Labs Report. Listen to our latest podcast, where Justine Levin-Allerhand sits down with Terrana Biosciences CEO Ryan Rapp to explore the company’s approach to RNA and what it could mean for the future of agriculture.    Tune in for an inside look at the scientific bets, technical hurdles, and experimental milestones behind building an RNA platform for agriculture: https://lnkd.in/g_D4M6vY

Come pioneer with us! We're looking for creative thinkers, exceptional scientists, and experienced company builders passionate about creating a better future for people and the planet. Open roles include: ⭐ Senior Strategic Transactions Lead, APEX ⭐ Strategic Transactions Counsel, APEX ⭐ Transactions Counsel, APEX ⭐ Senior Associate, Origination ⭐ Executive Assistant Explore open roles here: https://lnkd.in/dhM6gY6 #WeAreFlagship

To study whether engineered circular RNAs could move systemically, Terrana Biosciences’ team applied an engineered circular RNA construct, visualized using a yellow reporter signal, to the stem of an eggplant leaf and tracked its signal over time. Four weeks after localized delivery, the RNA was moving through the leaf vasculature and appearing in distal tissue, evidenced by significant yellowing of the upper leaves. Read our latest Labs Report: https://lnkd.in/gCc2gUTD

Moderna announced that the U.S. Food and Drug Administration has approved a new vaccine against seasonal influenza for use in adults 50 years and older. #FlagshipFounded 

Viroids are tiny loops of RNA found in plants whose small size belies their influence on plant physiology. Terrana Biosciences is taking inspiration from nature's design principles and directing them toward crop protection. In our latest deep dive on The Labs Report, we explore what this means for agriculture: https://lnkd.in/gCc2gUTD

Flagship Pioneering has been recognized as a 2026 Top Workplaces Culture Excellence Award winner in the following categories – Innovation, Work-Life Flexibility, Compensation & Benefits, Purpose & Values, Professional Development, and Appreciation.     At Flagship, we strive to make the impossible possible, pushing the boundaries of knowledge to pioneer a better future for people and the planet. We're united by a culture that encourages bold questions, imagination unconstrained by conventional thinking, and the rigor to translate breakthrough science into transformational outcomes.     Learn more about what makes Flagship a great place to pioneer: https://lnkd.in/gYi3eh-c #WeAreFlagship #BiggerLeaps