It's been over 3,700 years since a flash of light petrified nearly all human life. A 16-year-old genius named Senku Ishigami is suddenly revived to find himself in a world where all traces of human civilization have been eroded by time.
After discovering how to liberate people from stone, Senku and Taiji decide who they will free up first. A series of events influence them to liberate someone who is very strong.
Senku makes gunpowder to defeat Tsukasa. The gunpowder explodes and a smoke signal is made. Yuzuriha notices another smoke signal. Senku must decide to either cause more explosions as signals but risk revealing his position to Tsukasa.
Taiju and Yuzuriha flee from Tsukasa while taking Senku with them. It is discovered how Senku survived his first days after being freed from petrifaction.
Senku awakens after being nearly killed by Tsukasa and suggests splitting up with Yuzuriha and Taiju so they can spy on Tsukasa. A girl fights Tsukasa but is defeated and trapped under a tree. Senku finds the same girl and helps her.
Senku helps Kohaku bring hot water back to her village for her ill sister. Kohaku tells Senku about her village and that it has forty people. Senku is told he cannot enter the village. Senku explains to Chrome about the history of mankind.
Senku wants to make antibiotics and he explains how to Chrome and Kohaku. Senku decides to use magnets to collect iron. A child named Suika offers to help Senku. Senku decides to make ramen to appease the villagers and use their manpower.
Senku feeds the villagers ramen so they can help him make iron. Senku meets Asagiri Gen a man who's been unpetrified and is working for Tsukasa. Asagiri decides to help Senku. Senku wants to make a generator with the help of lightning.
To recover the most problematic ingredient in order to create sulfonamides, Ginro, Chrome, Kohaku and Senku will head to a zone of maximum danger. What kind of enemy will stand before them?
All that's needed to make antibiotics is alcohol. The best way to get some is to win the Grand Bout, which the Senku and his kingdom will also need to do in order to keep Magma away from Ruri and give her the drug.
After Magma's series of tricks to reach the final match, Chrome reveals a trick of his own. With a little extra help from Gen, Chrome just may be able to pull this one off.
Tsukasa's army is coming. Kinro struggles to hold the bridge against the deadly spearman Hyoga and his shock troops, but Senku and the villagers are ready with deadly new weapons of science.
Hyoga is disarmed, but the kingdom of science is still in danger - Ishigami village is in flames. And Tsukasa will soon know that Senku is still alive - How will the villagers fight off the coming invasion?
Work begins on creating the components for Senku's cell phone, but spinning gold wire is proving to be quite the task! Luckily, Chrome and Kaseki "invent" the water wheel and drastically improve the process!
With stored electricity, Senku takes the logical next step and creates light bulbs. After a little trial and error, Senku displays the new lights on a Christmas tree!
