The satellite photo at the beginning of the show is of South Boston, with the McCarthys all shown to be living on East 7th Street between H and I Streets.
Tyler Ritter playing a gay character; his dad pretended to be gay in Three's Company.
Laurie Metcalf and Jane Kaczmarek played sisters on "Malcolm in the Middle"
Lenny Clark had played Arthur in the original pilot. He and Jack McGee had worked together on Rescue Me (2004).
The show for its name because one of the directors had a crush on Jenny McCarthy. Shortly afterwards she married musician/actor Donny Walberg who was in New Kids on the Block with Joey McIntyre who plays Gerard on the show.