Lois and David Riess live a seemingly normal life as parents to three children, several grandchildren, and a thriving business in Blooming Prairie, Minnesota, until, one day, David's dead body is discovered and Lois goes on the run.
After the discovery of Pamela Hutchinson's body in Florida, a nationwide manhunt for the "Killer Grandma" begins and two weeks later, witnesses recognize Lois in Texas.