Christopher Reeve initially turned down the lead because he found Eric Ellis Overmyer's script to be too melodramatic and not medically accurate pertaining to his post-accident condition. Overmyer rewrote the screenplay, using Reeve's autobiography "Still Me" as a reference and this met with the star's approval.
The scene where Jason's breathing tube comes loose and he has to chatter his teeth to get the nurse's attention really happened to Christopher Reeve shortly after his accident.
When Jason Kemp (Christopher Reeve) is questioned by Detective Moore (Robert Forster), Kemp tells him he is the architect for a project called "The Woolrich Performing Arts Center". Cornell Woolrich is the author of the story "It Had To Be Murder" (published in Dime Detective Magazine in February 1942), upon which the movie Rear Window is based.