Kim Basinger replaced Jessica Lange as May. Lange was set to star opposite real-life partner Sam Shepard but became pregnant and the part had to be re-cast with Basinger stepping in.
The original production of the film's source stage play by Sam Shepard premiered on 8th February 1983 at the Magic Theatre in San Francisco and starred Kathy Baker and Ed Harris in the lead roles of May and Eddie respectively.
Robert Altman on the DVD says he has always been puzzled by the public's reaction to stage versions of "Fool for Love" wondering whether they saw the same play he did.
The motel building set looked so real that passers-by dropped in to book a room. Told that it was not a real motel, they then asked if they could get a meal at the adjacent restaurant, whom they were then also told was also a movie set.