- Married her fiancé of a year, Jerry O'Connell in a surprise backyard ceremony. The couple exchanged vows in front of 100 family and friends who thought that they had been invited to a barbecue.
- Has 2 daughters: Dolly O'Connell & Charlie O'Connell (b. December 28, 2008) with husband, Jerry O'Connell.
- First model to pose for "Sports Illustrated" in body paint.
- Rebecca's legal name was still Rebecca Romijn-Stamos after her 2005 divorce, but her legal last name is now Romijn-O'Connell.
- Was five months pregnant with twins Dolly and Charlie when she completed filming on Ugly Betty (2006).
- Has not kept in touch with former husband John Stamos since their divorce in 2005. For a while after, they did not speak to each other until (privately) in 2022 (as Rebecca confirmed it in a recent interview).
- Has appeared in five movies based on Marvel comic book characters: X-Men (2000), X2: X-Men United (2003), The Punisher (2004), X-Men: The Last Stand (2006), and X-Men: First Class (2011).
- When she was young her parents didn't have much money, so she had to shop at a thrift store called Value Village. She still shops at thrift stores.
- She got her first job at age 16 in her hometown of Berkeley, CA, at a gourmet poultry store cutting up dead chickens.
- Attended the University of California in Santa Cruz but dropped out in 1991 to pursue her modeling career.
- In 1997 was voted "GQ" Magazine's Woman of the Year.
- Her father is Dutch and her mother is American. Her maternal grandfather was of Dutch ancestry, while her maternal grandmother had English ancestry. Through her maternal grandmother, she is a relative of Dorothy Mengering, David Letterman's mother.
- Returned to work three months after giving birth to twins Dolly and Charlie when she began filming The Con Artist (2010).
- Appeared as Adrienne Barker, Dennis Finch's girlfriend (and later wife), on several episodes of Just Shoot Me! (1997) in 1999 and early 2000. During one scene for that show, Adrienne voices her contempt at Finch's obsession with science-fiction movies, and he retorts that she'd do anything for a part in one of those movies. In July 2000 she did have a part in such a movie, appearing as Mystique in X-Men (2000).
- Announced her engagement to Jerry O'Connell in September 2005.
- She and ex-husband John Stamos have both guest-starred on the situation comedy Friends (1994), though not in the same episode.
- In 1997 and 1999 was voted one of "People" Magazine's 50 Most Beautiful People.
- Delivered her twins Dolly and Charlie via Caesarean section.
- Along with Ian McKellen playing Magneto in five live-action X-Men and Wolverine films, James Franco & Willem Dafoe as Harry Osborn and Norman Osborn, respectively, in Sam Raimi's Spider-Man trilogy, Gene Hackman playing Lex Luthor in three (nonconsecutive) Superman films, Cillian Murphy playing Dr Jonathan Crane/The Scarecrow in Christopher Nolan's "Batman: The Dark Knight" trilogy, and Tom Hiddleston as Loki in the expansive Marvel Cinematic Universe series of films, she is one of the few people to play a comic book criminal in at least three live-action films (she has played Mystique in four films).
- On November 6, 2002, Femme Fatale (2002), in which she starred, opened on her 30th birthday in North America.
- Ranked #30 on "Maxim" magazine's Hot 100 of 2007 list.
- Ranked #60 on VH1's 100 Hottest Hotties
- Born on the same date as Thandiwe Newton.
- Sister-in-law of Charlie O'Connell.
- Named #80 on "Maxim: magazine's "Hot 100 of 2005" list.
- In 2002 ranked #82 in "Stuff" magazine's "102 Sexiest Women in the World".
- Ranked #58 on "Maxim" magazine's Hot 100 of 2008 list.
- In 2005 was ranked #99 in "FHM" magazine's "100 Sexiest Women in the World 2005" special supplement.
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