Caroline in the City

Caroline Duffy (Lea Thompson) is a cartoonist with a successful character. She hires grumpy starving-artist Richard Karinsky (Malcolm Gets) forced to lower himself as a colorist for her cartoon. Del Cassidy (Eric Lutes) is her ex. Annie Spadaro (Amy Pietz) is her next door neighbor best friend. For wacky physical humor, there is rollerskating deliveryboy Charlie (Andrew Lauer).

This works very well as a standard traditional Successful-Gal-who-Can't-Find-Love show. It lasted 4 seasons. It does ramble a bit with changing work and complications in the lead's relationships. Not all of it worked but Lea Thompson is always likable. It wasn't allowed a proper ending and it ended with a cliffhanger.