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Licensed Unlicensed Requires Authentication Published by De Gruyter November 16, 2005

Structured Antedependence Models for Functional Mapping of Multiple Longitudinal Traits

  • Wei Zhao , Wei Hou , Ramon C. Littell and Rongling Wu
From the journal Statistical Applications in Genetics and Molecular Biology
https://doi.org/10.2202/1544-6115.1136

In this article, we present a statistical model for mapping quantitative trait loci (QTL) that determine growth trajectories of two correlated traits during ontogenetic development. This model is derived within the maximum likelihood context, incorporated by mathematical aspects of growth processes to model the mean vector and by structured antedependence (SAD) models to approximate time-dependent covariance matrices for longitudinal traits. It provides a quantitative framework for testing the relative importance of two mechanisms, pleiotropy and linkage, in contributing to genetic correlations during ontogeny. This model has been employed to map QTL affecting stem height and diameter growth trajectories in an interspecific hybrid progeny of Populus, leading to the successful discovery of three pleiotropic QTL on different linkage groups. The implications of this model for genetic mapping within a broader context are discussed.

Keywords: Structured antedependence model; EM algorithm; Growth curve; Multivariate analysis; Quantitative trait loci
Published Online: 2005-11-16

©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston

From the journal
Statistical Applications in Genetics and Molecular Biology
Statistical Applications in Genetics and Molecular Biology
Volume 4 Issue 1
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