SableMiles

AI is not just CHATGPT…. As someone who adopted data modelling over 50 years ago it amuses me to see the amount of coverage AI is getting and how misinformed a lot of it is. The key lesson that has not been learned by the generation promoting AI is the same as it was 50 years ago – Garbage In, Garbage Out. When Tesco launched their Clubcard their biggest problem was coping with the sheer quantity of data. Even with two IBM AS400’s (the benchmark in computing at the time) they couldn’t accurately predict what a store would take when planning new openings. The plus or minus 15% forecast was far too broad to guarantee that new stores would be profitable. Then there was Direct Product Profitability – where to put products to maximise uptake. The progress made back in the 80’s was the foundation of what we are seeing today across many sectors. However, senior management, particularly C Suite, see AI as a silver bullet much like management were heralding company websites back in the 90’s as some sort of miracle value add. In reality much of it was snake oil. AI depends heavily on the questions posed, the data the response is based upon and the analysis that is undertaken. Only 20 or so years ago the industry was being sense checked with the phrase ‘Insight not Information’. Today, with so much information available and huge amounts of computing power there is still a weak link, the organic angle. It’s easy to get the right answer to the wrong question but it’s even more dangerous to trust and implement the answer without challenging it. The organic element required to successfully implement AI is still in training and the generation that grew up with calculators instead of PCs has much to offer. With over 45 years of experience Sable-Miles is still being asked the same questions. The audience might have changed and our answers more composed but thinking just inside the box and managing change is just as relevant today as it was in the 80’s. Thinking outside the box without understanding the limitations and history of the box is downright dangerous!

Morning everyone. I’m pleased to announce that after almost accidentally deleting all the company’s email addresses, I’ve finally finished updating our website (link below). Feel free to take a look! https://lnkd.in/e-au9Ana A little about us: Sable-Miles is a boutique family consultancy supported by a network of highly experienced associates in London. We primarily work with companies in the Critical Minerals & Metals, Life Sciences, and Sustainability sectors, while also looking to expand our work into the Technology and AI space. We’re always keen to connect with new people and grow our network. Whether you’re an institution or investor looking for innovative projects to invest in or partner with, or a business seeking to streamline operations, refine its strategy, raise capital or increase market exposure, it would be great to connect. You can get in touch via LinkedIn or through the contact form on our website. One feature I think you’ll find quite interesting is our Current Projects section, which provides a redacted overview of some of the exciting opportunities we’re working on.

Limitations of current Osteoarthritis treatments. Osteoarthritis (OA) is the most common joint disease, affecting around 630 million people worldwide. It occurs when the protective cartilage that cushions the ends of bones wears down over time. OA can damage any joint, but the most commonly affected joints are: hands, knees, hips and spine. (It’s actually an old wives’ tale that cracking your knuckles leads to arthritis) THANK GOD! Yet despite the scale of the problem, the treatment options remain largely palliative rather than regenerative. Conservative treatments focus on symptom relief, while surgical and cell-based strategies often generate cartilage that is structurally inferior to native cartilage. In many cases, this repair tissue lacks the appropriate biomechanical strength and full integration with surrounding cartilage, which results in limited durability and eventual joint replacement. This exposes a significant unmet need in osteoarthritis care: approaches capable of restoring/repairing cartilage that more closely replicate native human tissue in both structure and mechanical performance. We’ve had the pleasure over the last few months of being introduced to an emerging scaffold-free regenerative cartilage strategy, which generates constructs with native-like architecture, with the aim of achieving long-term functional repair. If successful, this approach could: 1.  Reduce repeat interventions 2.  Delay/eliminate joint replacement. 3.  Improve patient outcomes. 4.  Lower Long-term healthcare costs.

Let’s talk about Albinism 🫱🏻… Very interesting conversation last week with a group of Scientists from a University who are developing a diagnostic platform designed to alleviate the symptoms of Albinism. If you do a quick Google search, you’ll find that it affects roughly 1 in 17,000 to 20,000 in European/American populations; however, there are higher rates in Africa, roughly 1 in 1,000 to 5,000. In actuality, the number of people affected by this condition is likely to be much higher, with many people often being undiagnosed. The target generic variant is present in up to 25% of the European population, meaning there is a huge unmet need for non-clinical pigmentation applications, including safe tanning (cosmetics) and medical prophylaxis tanning (skin cancer prevention). It’s quite staggering for a WHO-defined “global health priority” affecting 2 million people, there are currently no FDA-approved pharmacological treatments as of yet.