ESMFold2

ESMFold2

Biohub
+
+

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About

BioNeMo is an AI-powered drug discovery cloud service and framework built on NVIDIA NeMo Megatron for training and deploying large biomolecular transformer AI models at a supercomputing scale. The service includes pre-trained large language models (LLMs) and native support for common file formats for proteins, DNA, RNA, and chemistry, providing data loaders for SMILES for molecular structures and FASTA for amino acid and nucleotide sequences. The BioNeMo framework will also be available for download for running on your own infrastructure. ESM-1, based on Meta AI’s state-of-the-art ESM-1b, and ProtT5 are transformer-based protein language models that can be used to generate learned embeddings for tasks like protein structure and property prediction. OpenFold, a deep learning model for 3D structure prediction of novel protein sequences, will be available in BioNeMo service.

About

ESMFold2 is the successor to ESMFold, setting a new state of the art for single-sequence structure prediction and enabling the generation of new functional proteins through searching the ESMC model’s latent space. The model predicts high-resolution, all-atom 3D structures of biomolecular complexes directly from sequence, with optional multiple sequence alignment input for enhanced accuracy on challenging targets. It is designed for structure prediction using sequence and structure modalities, with ESM representations powering a series of looped folding layers and a diffusion model projecting pairwise representations to atomic-resolution predictions. ESMFold2 predicts protein structures directly from amino acid sequences and outputs comprehensive structural information, including all-atom coordinates for backbone and side chains, confidence metrics, and optional distogram predictions for detailed structural analysis.

Platforms Supported

Windows Not Supported
Mac Not Supported
Linux Not Supported
Cloud Supported
On-Premises Not Supported
iPhone Not Supported
iPad Not Supported
Android Not Supported
Chromebook Not Supported

Platforms Supported

Windows Not Supported
Mac Not Supported
Linux Not Supported
Cloud Supported
On-Premises Not Supported
iPhone Not Supported
iPad Not Supported
Android Not Supported
Chromebook Not Supported

Audience

Organizations looking for a powerful Drug Discovery solution

Audience

Structural biology researchers who need fast, high-resolution protein structure prediction from sequence for analysis, exploration, and experimental planning

Support

Phone Support Supported
24/7 Live Support Not Supported
Online Supported

Support

Phone Support Not Supported
24/7 Live Support Not Supported
Online Supported

API

Offers API Not Supported

API

Offers API Supported

Screenshots and Videos

Screenshots and Videos

Pricing

No information available.
Free Version Not Supported
Free Trial Not Supported

Pricing

Free
Free Version Supported
Free Trial Not Supported

Reviews/Ratings

Overall 0.0 / 5
ease 0.0 / 5
features 0.0 / 5
design 0.0 / 5
support 0.0 / 5

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Reviews/Ratings

Overall 0.0 / 5
ease 0.0 / 5
features 0.0 / 5
design 0.0 / 5
support 0.0 / 5

This software hasn't been reviewed yet. Be the first to provide a review:

Review this Software

Training

Documentation Supported
Webinars Supported
Live Online Not Supported
In Person Not Supported

Training

Documentation Supported
Webinars Not Supported
Live Online Not Supported
In Person Not Supported

Company Information

NVIDIA
Founded: 1993
United States
www.nvidia.com/en-us/gpu-cloud/bionemo/

Company Information

Biohub
Founded: 2016
United States
biohub.ai/models/esmfold2

Alternatives

Alternatives

ESMFold2

ESMFold2

Biohub
ESMC

ESMC

Biohub
ESMC

ESMC

Biohub
Evo 2

Evo 2

Arc Institute
AlphaFold

AlphaFold

DeepMind
HyperProtein

HyperProtein

Hypercube

Categories

AI Science Supported
Drug Discovery Supported
Healthcare AI Supported

Categories

AI Models Supported
AI Science Supported

Integrations

Biohub Not Supported
Evo 2 Supported
NVIDIA AI Foundations Supported
NVIDIA Clara Supported
NVIDIA NeMo Megatron Supported
Python Not Supported

Integrations

Biohub Supported
Evo 2 Not Supported
NVIDIA AI Foundations Not Supported
NVIDIA Clara Not Supported
NVIDIA NeMo Megatron Not Supported
Python Supported
Claim NVIDIA BioNeMo and update features and information
Claim NVIDIA BioNeMo and update features and information
Claim ESMFold2 and update features and information
Claim ESMFold2 and update features and information