NVIDIA BioNeMoNVIDIA
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ESMFold2Biohub
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About
BioNeMo is an AI-powered drug discovery cloud service and framework built on NVIDIA NeMo Megatron for training and deploying large biomolecular transformer AI models at a supercomputing scale. The service includes pre-trained large language models (LLMs) and native support for common file formats for proteins, DNA, RNA, and chemistry, providing data loaders for SMILES for molecular structures and FASTA for amino acid and nucleotide sequences. The BioNeMo framework will also be available for download for running on your own infrastructure. ESM-1, based on Meta AI’s state-of-the-art ESM-1b, and ProtT5 are transformer-based protein language models that can be used to generate learned embeddings for tasks like protein structure and property prediction. OpenFold, a deep learning model for 3D structure prediction of novel protein sequences, will be available in BioNeMo service.
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About
ESMFold2 is the successor to ESMFold, setting a new state of the art for single-sequence structure prediction and enabling the generation of new functional proteins through searching the ESMC model’s latent space. The model predicts high-resolution, all-atom 3D structures of biomolecular complexes directly from sequence, with optional multiple sequence alignment input for enhanced accuracy on challenging targets. It is designed for structure prediction using sequence and structure modalities, with ESM representations powering a series of looped folding layers and a diffusion model projecting pairwise representations to atomic-resolution predictions. ESMFold2 predicts protein structures directly from amino acid sequences and outputs comprehensive structural information, including all-atom coordinates for backbone and side chains, confidence metrics, and optional distogram predictions for detailed structural analysis.
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Platforms Supported
Windows
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Mac
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Linux
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Cloud
Supported
On-Premises
Not Supported
iPhone
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iPad
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Android
Not Supported
Chromebook
Not Supported
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Platforms Supported
Windows
Not Supported
Mac
Not Supported
Linux
Not Supported
Cloud
Supported
On-Premises
Not Supported
iPhone
Not Supported
iPad
Not Supported
Android
Not Supported
Chromebook
Not Supported
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Audience
Organizations looking for a powerful Drug Discovery solution
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Audience
Structural biology researchers who need fast, high-resolution protein structure prediction from sequence for analysis, exploration, and experimental planning
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Support
Phone Support
Supported
24/7 Live Support
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Online
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Support
Phone Support
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24/7 Live Support
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Online
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API
Offers API
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API
Offers API
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Pricing
No information available.
Free Version
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Free Trial
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Pricing
Free
Free Version
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Free Trial
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Reviews/
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Training
Documentation
Supported
Webinars
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Live Online
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In Person
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Training
Documentation
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Webinars
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Live Online
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In Person
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Company InformationNVIDIA
Founded: 1993
United States
www.nvidia.com/en-us/gpu-cloud/bionemo/
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Company InformationBiohub
Founded: 2016
United States
biohub.ai/models/esmfold2
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Integrations
Biohub
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Evo 2
Supported
NVIDIA AI Foundations
Supported
NVIDIA Clara
Supported
NVIDIA NeMo Megatron
Supported
Python
Not Supported
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Integrations
Biohub
Supported
Evo 2
Not Supported
NVIDIA AI Foundations
Not Supported
NVIDIA Clara
Not Supported
NVIDIA NeMo Megatron
Not Supported
Python
Supported
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