Izvorni kod stranice Fluoksetin

{{Chembox
|  verifiedrevid = 424117487
|  ImageFileL1 = Fluoxetine-2D-skeletal.svg
|  ImageSizeL1 = 140
|  ImageNameL1 = Structural formula of fluoxetine
|  ImageFileR1 = S-fluoxetine-3D-vdW.png
|  ImageSizeR1 = 121
|  ImageNameR1 = Spacefill model of fluoxetine (3S)
|  PIN = 
|  IUPACName = ''N''-metil-3-fenil-3-[4-(trifluorometil)fenoksi]propan-1-amin
|  SystematicName = 
| Section1 = {{Chembox Identifiers
|  CASNo = 54910-89-3
|  CASNo_Ref = {{cascite|correct|CAS}}
|  PubChem = 3386
|  PubChem_Ref = {{Pubchemcite|correct|Pubchem}}
|  ChemSpiderID = 3269
|  ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
|  UNII = 01K63SUP8D
|  UNII_Ref = {{fdacite|correct|FDA}}
|  DrugBank = APRD00530
|  KEGG_Ref = {{keggcite|correct|kegg}}
|  KEGG = D00326
|  MeSHName = Fluoxetine
|  ChEBI = 5118
|  IUPHAR_ligand = 203
|  ATCCode_prefix = N06
|  ATCCode_suffix = AB03
|  Beilstein = 39914106
|  Gmelin = 
|  3DMet = 
|  SMILES = CNCCC(c1ccccc1)Oc2ccc(cc2)C(F)(F)F
|  SMILES1 = CNCCC(OC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1
|  ChEMBL_Ref = {{ebicite|correct|EBI}}
|  ChEMBL = 41
|  StdInChI = 1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3
|  StdInChI_Ref = {{stdinchicite|correct|chemspider}}
|  InChI = 1/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3
|  StdInChIKey = RTHCYVBBDHJXIQ-UHFFFAOYSA-N
|  StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
|  InChIKey = RTHCYVBBDHJXIQ-UHFFFAOYAV}}
| Section2 = {{Chembox Properties
|  C = 17
|  H = 18
|  F = 3
|  N = 1
|  O = 1
|  ExactMass = 309,134048818 g mol<sup>-1</sup>
|  Appearance = Beli kristali
|  MeltingPtCL = 179
|  MeltingPtCH = 182
|  Solubility = 50 g L<sup>-1</sup>
|  LogP = 4,6}}
| Section3 = {{Chembox Pharmacology
|  Bioavail = 72% (pik tokom 6-8 sata)
|  AdminRoutes = Oralno
|  Metabolism = Hepatički
|  HalfLife = 1-3 dana (akutno)<br />4-6 dana (hronično)
|  ProteinBound = 94,5%
|  Excretion = Bubrezi (80%)<br />probavni sistem (15%)
|  Legal_US = Rx
|  PregCat_AU = C
|  PregCat_US = C}}
| Section4 = {{Chembox Hazards
|  LD50 = 284 mg kg<sup>-1</sup> (oralno na miševima)}}
}}
[[Datoteka:Prozac pills cropped.jpg|thumb|right|Fluoksetin 20 mg kapsule]]
'''Fluoksetin''' (''Prozak'', ''Sarafem'') je [[antidepresivi|antidepresiv]] iz klase [[Selektivni inhibitor preuzimanja serotonina|selektivnih inhibitora preuzimanja serotonina]] (SSRI). Njega proizvodi i prodaje [[Eli Lili i kompanija]]. U kombinaciji sa [[olanzapin]]om je poznat kao [[simbiaks]].Fluoksetin je odobren za lečenje [[klinička depresija|kliničke depresije]] (što obuhvata pedijatrijsku depresiju), [[opsesivno-kompulzivni poremećaj]] (kod odraslih i dece), [[bulimija|bulimiju]], [[panični poremećaj]] i [[predmenstrualni disforični poremećaj]].<ref name="RxList">{{cite web | url = http://www.rxlist.com/cgi/generic/fluoxetine_cp.htm | title = Prozac Pharmacology, Pharmacokinetics,Studies, Metabolism | year = 2007 | accessdate = 14. 04. 2007. | publisher = RxList.com | archivedate = 2007-04-10 | archiveurl = https://web.archive.org/web/20070410122720/http://www.rxlist.com/cgi/generic/fluoxetine_cp.htm | deadurl = yes }}</ref><ref name=AHFS>{{cite web|title=Fluoxetine Hydrochloride|url=http://www.drugs.com/monograph/fluoxetine-hydrochloride.html|work=The American Society of Health-System Pharmacists|accessdate=3 April 2011}}</ref> On je takođe korišten za [[katapleksija|katapleksiju]], [[gojaznost]], i [[alkoholna zavisnost|alkoholnu zavisnost]].<ref name=AHFS/>

Uprkos dostupnosti novijih lekova, fluoksetin je zadržao izuzetnu popularnost. Preko 22.2 miliona recepata za generičke formulacije fluoksetina je ispunjeno u SAD-u [[2007]],<ref name="Verispan generic drugs 2007">{{cite web | url = http://www.drugtopics.com/drugtopics/article/articleDetail.jsp?id=491181 | title = Top 200 Generic Drugs by Units in 2007 | author = Verispan | publisher = Drug Topics | access-date = 2013-04-19 | archivedate = 2012-07-11 | archiveurl = https://www.webcitation.org/694ZTEd4X?url=http://drugtopics.modernmedicine.com/drugtopics/data/articlestandard//drugtopics/072008/491181/article.pdf | deadurl = yes }}</ref> što ga čini trećim najviše propisivanim antidepresivom, posle [[sertralin]]a (SSRI koji je postao generički lek [[2006]]) i [[escitalopram]]a (ne-generičkog SSRI).<ref name="Verispan generic drugs 2007"/><ref name="Verispan brand drugs 2007">{{cite web | url = http://www.drugtopics.com/drugtopics/article/articleDetail.jsp?id=491207 | title = Top 200 Brand Drugs by Units in 2007 | accessdate = 30. 03. 2008. | author = Verispan | date = 18. 02. 2008. | format = PDF | publisher = Drug Topics | archivedate = 2012-07-11 | archiveurl = https://www.webcitation.org/694ZTgSbi?url=http://drugtopics.modernmedicine.com/drugtopics/data/articlestandard//drugtopics/072008/491207/article.pdf | deadurl = yes }}</ref>

== Nuspojave ==
[[Seksualna disfunkcija]] je uobičajena nuspojava [[Selektivni inhibitor preuzimanja serotonina|SSRI]] lekova. Specifično, nuspojave su obično poteškoće sa nadražajom, erektilna disfunkcija, nedostatak interesa za seks, i [[anorgazmija]] (problem dostizanja orgazma). Genitalna anestezija,<ref>{{cite journal |author=Bolton JM, Sareen J, Reiss JP |title=Genital anaesthesia persisting six years after sertraline discontinuation |journal=J Sex Marital Ther |volume=32 |issue=4 |pages=327–30 |year=2006 |pmid=16709553 |doi=10.1080/00926230600666410 |url=http://www.informaworld.com/openurl?genre=article&doi=10.1080/00926230600666410&magic=pubmed}}</ref> gubitak ili umanjenje responsa na seksualni stimulus, i ejakulatorna anhedonija su takođe moguće. Mada su obično reverzibilne, te seksualne nuspojave mogu da traju mesecima i godinama.<ref>{{cite journal |author=Csoka AB, Bahrick AS, Mehtonen O-P |title=Persistent Sexual Dysfunction after Discontinuation of Selective Serotonin Reuptake Inhibitors (SSRIs) |journal=J Sex Med. |volume=5 |issue=1 |pages=227–33 |year=2008 |doi=10.1111/j.1743-6109.2007.00630.x |url=http://www.blackwell-synergy.com/doi/abs/10.1111/j.1743-6109.2007.00630.x |pmid=18173768 |access-date=2013-04-19 |archive-date=2018-12-28 |archive-url=https://web.archive.org/web/20181228174701/http://www.blackwell-synergy.com/doi/abs/10.1111/j.1743-6109.2007.00630.x |dead-url=yes }}</ref> To je poznato kao [[post SSRI seksualna disfunkcija]].

== Literatura ==
{{reflist|2}}

== Spoljašnje veze ==
{{Commonscat|Fluoxetine}}
* [http://www.breggin.com/ Psihijatrijske činjenice]
* [http://www.nature.com/drugdisc/nj/articles/nrd1811.html Biografija Davida Vonga, jednog od izumitelja Prozaka]
* [http://www.invent.org/hall_of_fame/105.html Biografija Brajana Moloja, jednog od izumitelja Prozaka]
* [http://money.cnn.com/magazines/fortune/fortune_archive/2005/11/28/8361973/index.htm Problem s Prozakom]
* [http://druginfo.nlm.nih.gov/drugportal/dpdirect.jsp?name=Fluoxetine Informacije o leku]
{{-}}
{{Antidepresivi}}
{{Serotonergici}}

[[Kategorija:Selektivni inhibitori preuzimanja serotonina]]
[[Kategorija:Esencijalni lekovi Svetske zdravstvene organizacije]]
[[Kategorija:Fenolni etri]]
[[Kategorija:Organofluoridi]]